Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0029 | 0.0559 | 0.1265 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1222 | 0.209 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0178 | 0.0372 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0785 | 0.1609 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0046 | 0.1069 | 0.2447 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0453 | 0.4761 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0334 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0178 | 0.0372 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0183 | 0.5304 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0021 | 0.0317 | 0.2897 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0453 | 0.0375 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0047 | 0.111 | 0.1038 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0178 | 0.0305 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0785 | 0.1343 |
Trichomonas vaginalis | nuclear lim interactor-interacting factor, putative | 0.0014 | 0.0081 | 0.0662 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0021 | 0.0317 | 0.2897 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1308 | 0.2803 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0334 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0158 | 0.4551 | 0.4507 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0178 | 0.0235 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0453 | 0.0375 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0046 | 0.1069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0178 | 0.0235 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1222 | 0.2804 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0021 | 0.0317 | 0.2897 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0046 | 0.1069 | 0.1891 |
Schistosoma mansoni | cpg binding protein | 0.01 | 0.2741 | 0.4688 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0453 | 0.0375 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0075 | 0.0129 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0317 | 0.2897 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0021 | 0.0317 | 0.2897 |
Echinococcus granulosus | Carboxy terminal domain RNA polymerase II | 0.0014 | 0.0081 | 0.0156 |
Trichomonas vaginalis | dullard protein, putative | 0.0014 | 0.0081 | 0.0662 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0155 | 0.446 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1308 | 0.2811 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0155 | 0.446 | 0.7627 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0151 | 0.4326 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0453 | 0.3767 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0453 | 0.085 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0047 | 0.111 | 0.1038 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1308 | 0.2803 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0021 | 0.0317 | 0.2897 |
Trichomonas vaginalis | nuclear lim interactor-interacting factor, putative | 0.0014 | 0.0081 | 0.0662 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0042 | 0.0951 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0029 | 0.0559 | 0.1103 |
Echinococcus granulosus | cpg binding protein | 0.01 | 0.2741 | 0.6327 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0021 | 0.0317 | 0.2897 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1222 | 0.2719 |
Schistosoma mansoni | nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) | 0.0014 | 0.0081 | 0.0138 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1308 | 0.2811 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0029 | 0.0547 | 0.1066 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.1324 | 0.238 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0023 | 0.0381 | 0.0853 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0178 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0081 | 0.0012 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0317 | 0.2897 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0046 | 0.1069 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0023 | 0.0381 | 0.0853 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0013 | 0.0022 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0042 | 0.0951 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0094 | 0.2575 | 0.57 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0042 | 0.0951 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.017 | 0.0205 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0047 | 0.111 | 0.1038 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0021 | 0.0317 | 0.2897 |
Loa Loa (eye worm) | acetyltransferase | 0.0155 | 0.446 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1222 | 0.209 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1222 | 0.2804 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0158 | 0.4551 | 0.4507 |
Trichomonas vaginalis | dullard protein, putative | 0.0014 | 0.0081 | 0.0662 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0158 | 0.4551 | 0.4507 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0176 | 0.5104 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0176 | 0.5104 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.02 | 0.5848 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0029 | 0.0559 | 0.1227 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0023 | 0.0381 | 0.0651 |
Echinococcus multilocularis | 0.0014 | 0.0081 | 0.0152 | |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0178 | 0.0383 |
Echinococcus multilocularis | Carboxy terminal domain RNA polymerase II | 0.0014 | 0.0081 | 0.0152 |
Onchocerca volvulus | 0.0094 | 0.2575 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1222 | 0.2607 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0317 | 0.2897 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0023 | 0.0381 | 0.0827 |
Trichomonas vaginalis | helicase, putative | 0.0021 | 0.0317 | 0.2897 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0178 | 0.0305 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0178 | 0.0223 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0453 | 0.0861 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0785 | 0.1619 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0046 | 0.1069 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0155 | 0.446 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0317 | 0.2897 |
Trichomonas vaginalis | nuclear lim interactor-interacting factor, putative | 0.0014 | 0.0081 | 0.0662 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0317 | 0.2897 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1222 | 0.209 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0014 | 0.0074 | 0.0127 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0317 | 0.2897 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0334 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0317 | 0.2897 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0317 | 0.2897 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.1222 | 0.2616 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0046 | 0.1069 | 0.1891 |
Schistosoma mansoni | cpg binding protein | 0.0094 | 0.2575 | 0.4403 |
Trichomonas vaginalis | dullard protein, putative | 0.0014 | 0.0081 | 0.0662 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0047 | 0.111 | 0.1038 |
Entamoeba histolytica | NLI interacting factor-like phosphatase domain-containing protein | 0.0014 | 0.0081 | 0.0847 |
Echinococcus multilocularis | cpg binding protein | 0.01 | 0.2741 | 0.6135 |
Brugia malayi | CXXC zinc finger family protein | 0.0094 | 0.2575 | 0.5695 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0453 | 0.4761 |
Echinococcus granulosus | CTD small phosphatase protein like | 0.0014 | 0.0081 | 0.0156 |
Schistosoma mansoni | cpg binding protein | 0.01 | 0.2741 | 0.4688 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0453 | 0.0712 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0023 | 0.0381 | 0.0827 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0021 | 0.0317 | 0.2897 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0178 | 0.0223 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0178 | 0.0383 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0178 | 0.0305 |
Schistosoma mansoni | nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) | 0.0014 | 0.0081 | 0.0138 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0317 | 0.2897 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0178 | 0.0372 |
Trichomonas vaginalis | nuclear lim interactor-interacting factor, putative | 0.0014 | 0.0081 | 0.0662 |
Plasmodium falciparum | NLI interacting factor-like phosphatase, putative | 0.0014 | 0.0081 | 0.0847 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0453 | 0.0375 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0178 | 0.0305 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0057 | 0.1428 | 0.1359 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1222 | 0.2719 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 2.9 % | Induction of weight loss in C3H/HeN mouse at 12.6 umol/kg, ip after 60 days (Rvb = 41.6 +/- 8.7 %) | ChEMBL. | 22200344 |
Activity (functional) | = 11.6 % | Induction of weight loss in C3H/HeN mouse at 4.2 umol/kg, ip after 60 days (Rvb = 33.3 +/- 5.0 %) | ChEMBL. | 22200344 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.