Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0153 | 0.1749 | 0.4315 |
Leishmania major | DNA topoisomerase ii | 0.0137 | 0.1512 | 0.5227 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0153 | 0.1749 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0298 | 0.3918 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0153 | 0.1743 | 0.43 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0298 | 0.3918 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0153 | 0.1749 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0988 | 0.0592 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0703 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0137 | 0.1512 | 0.5227 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0143 | 0.1604 | 0.1604 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0145 | 0.1633 | 0.925 |
Loa Loa (eye worm) | hypothetical protein | 0.0644 | 0.9113 | 0.9755 |
Giardia lamblia | DNA topoisomerase II | 0.0146 | 0.1642 | 0.4118 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0153 | 0.1749 | 0.1874 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0153 | 0.1743 | 0.1743 |
Schistosoma mansoni | DNA topoisomerase II | 0.0153 | 0.1743 | 0.1743 |
Brugia malayi | nuclear hormone receptor | 0.0658 | 0.933 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0153 | 0.1749 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0153 | 0.1749 | 0.4463 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0153 | 0.1749 | 0.4315 |
Plasmodium falciparum | DNA gyrase subunit B | 0.005 | 0.0204 | 0.0927 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0083 | 0.0694 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0137 | 0.1512 | 0.5227 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0153 | 0.1749 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0148 | 0.1666 | 0.1785 |
Brugia malayi | Probable DNA topoisomerase II | 0.0153 | 0.1743 | 0.1868 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0153 | 0.1749 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0137 | 0.1512 | 0.5227 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.005 | 0.0204 | 0.0624 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0153 | 0.1743 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0674 | 0.9573 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0148 | 0.1666 | 0.1666 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0153 | 0.1749 | 0.4315 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.0047 | 0.0121 |
Loa Loa (eye worm) | acetyltransferase | 0.0148 | 0.1666 | 0.1356 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0153 | 0.1743 | 0.1868 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0148 | 0.1666 | 0.1666 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0658 | 0.933 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1749 | 0.1449 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0145 | 0.1633 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.005 | 0.0204 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.0102 | 0.0102 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0153 | 0.1743 | 0.1743 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0153 | 0.1743 | 0.1443 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0153 | 0.1743 | 0.4448 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.005 | 0.0204 | 0.0626 |
Mycobacterium ulcerans | hypothetical protein | 0.0153 | 0.1749 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0145 | 0.1633 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0153 | 0.1743 | 0.1868 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0703 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0153 | 0.1743 | 0.9965 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0988 | 0.0592 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0153 | 0.1743 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0137 | 0.1512 | 0.5227 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.034 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.908 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.778 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.741 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.7 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.615 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.596 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.579 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.553 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.543 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.267 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.