Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | prolyl oligopeptidase family protein | 0.0209 | 0.1688 | 0.1688 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0209 | 0.1688 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0114 | 0 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.1688 | 0.1688 |
Echinococcus multilocularis | acetylcholinesterase | 0.0677 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0677 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0677 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0114 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0677 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.1688 | 0.1688 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0114 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0114 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0677 | 1 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0209 | 0.1688 | 0.1688 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0114 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0677 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0677 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0677 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0677 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0677 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0677 | 1 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0209 | 0.1688 | 0.1688 |
Loa Loa (eye worm) | carboxylesterase | 0.0677 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0114 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2 uM | Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) | ChEMBL. | 14584950 |
IC50 (binding) | = 0.2 uM | Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) | ChEMBL. | 14584950 |
IC50 (binding) | = 110 uM | Inhibitory activity against Dipeptidyl Peptidase II | ChEMBL. | 12270155 |
IC50 (binding) | = 110 uM | Inhibitory activity of compound against Dipeptidyl-peptidase II (DPP II) | ChEMBL. | 14584950 |
IC50 (binding) | = 110 uM | Inhibitory activity against Dipeptidyl Peptidase II | ChEMBL. | 12270155 |
IC50 (binding) | = 110 uM | Inhibitory activity of compound against Dipeptidyl-peptidase II (DPP II) | ChEMBL. | 14584950 |
Ki (binding) | = 0.2 uM | Inhibition of Dipeptidyl Peptidase IV | ChEMBL. | 12270155 |
Ki (binding) | = 0.2 uM | Inhibition of Dipeptidyl Peptidase IV | ChEMBL. | 12270155 |
Selectivity index (binding) | = | Selectivity index of compound was determined as value for DPP IV divided by value for DPP II | ChEMBL. | 14584950 |
Selectivity index (binding) | = 0 | Selectivity index of compound was determined as value for DPP IV divided by value for DPP II | ChEMBL. | 14584950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.