Detailed information for compound 1594513

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 539.132 | Formula: C29H35ClN4O2S
  • H donors: 1 H acceptors: 2 LogP: 4.95 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)[C@H](N[C@@H]1CC[C@@H]([C@H](C1)c1cscc1)C(=O)N1CCN(CC1)c1ccc(cn1)Cl)C
  • InChi: 1S/C29H35ClN4O2S/c1-20(21-3-7-25(36-2)8-4-21)32-24-6-9-26(27(17-24)22-11-16-37-19-22)29(35)34-14-12-33(13-15-34)28-10-5-23(30)18-31-28/h3-5,7-8,10-11,16,18-20,24,26-27,32H,6,9,12-15,17H2,1-2H3/t20-,24-,26+,27-/m1/s1
  • InChiKey: YUOZXCMLTVGRGZ-PBBMNAFMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus neuropeptides B/W receptor 1 Starlite/ChEMBL References
Homo sapiens neuropeptides B/W receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis growth hormone secretagogue receptor type 1 neuropeptides B/W receptor 1 328 aa 296 aa 21.3 %
Echinococcus multilocularis G-protein coupled receptor, putative neuropeptides B/W receptor 1 329 aa 306 aa 23.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0065 0.007
Brugia malayi nuclear hormone receptor 0.0011 0.0065 0.007
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0356 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0065 0.007
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.2175 0.8997
Loa Loa (eye worm) hypothetical protein 0.0012 0.0113 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0356 0.0356
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.1629 0.7137
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0065 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0356 0.0356
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0356 0.1472
Loa Loa (eye worm) cysteine protease 0.0018 0.0356 0.0314
Loa Loa (eye worm) hypothetical protein 0.005 0.1629 0.1691
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0356 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0356 0.0356
Onchocerca volvulus 0.0018 0.0356 0.0293
Trypanosoma cruzi ISWI complex protein 0.0016 0.0249 0.1031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0065 0.007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0065 0.007
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0356 1
Brugia malayi Pre-SET motif family protein 0.0225 0.874 0.9384
Brugia malayi nuclear receptor NHR-88 0.0011 0.0065 0.007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.093 0.2981
Loa Loa (eye worm) hypothetical protein 0.0018 0.0356 0.0314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.2417 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.1599 0.7006
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.2069 0.2221
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.874 0.9379
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0356 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0356 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0356 0.0356
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0113 0.3182
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0065 0.007
Schistosoma mansoni hypothetical protein 0.0021 0.0468 0.205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.2417 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.2282 0.5
Brugia malayi cathepsin L-like precursor 0.0012 0.0113 0.0122
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.2282 0.9379
Brugia malayi Cathepsin L-like precursor 0.0018 0.0356 0.0382
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.2417 1
Echinococcus multilocularis cysteine protease 0.0018 0.0356 0.0382
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0065 0.007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0065 0.007
Loa Loa (eye worm) hypothetical protein 0.0039 0.1195 0.1222
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0356 0.0356
Echinococcus granulosus cathepsin l1 0.0012 0.0113 0.0122
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0356 0.1558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0356 0.0356
Loa Loa (eye worm) ctsf protein 0.0018 0.0356 0.0314
Leishmania major cathepsin L-like protease 0.0069 0.2417 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.1629 0.1749
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0065 0.0284
Loa Loa (eye worm) hypothetical protein 0.0012 0.0113 0.0052
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0546 0.0586
Schistosoma mansoni hypothetical protein 0.0049 0.1599 0.7006
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.1095 0.1175
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0882 0.0947
Leishmania major cathepsin L-like protease 0.0018 0.0356 0.0491
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.2282 1
Leishmania major cathepsin L-like protease 0.0069 0.2417 1
Leishmania major cathepsin L-like protease 0.0018 0.0356 0.0491
Schistosoma mansoni coup transcription factor 0.0011 0.0065 0.0284
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0356 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0356 0.0356
Brugia malayi Cathepsin L-like precursor 0.0012 0.0113 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.2417 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0356 0.0382
Echinococcus multilocularis zinc finger protein 0.002 0.0424 0.0456
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.2282 0.5
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0065 0.0284
Echinococcus granulosus zinc finger protein 0.002 0.0424 0.0456
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0065 0.007
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.2282 0.245
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0321 0.1407
Schistosoma mansoni zinc finger protein 0.0016 0.0249 0.1092
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0065 0.007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0065 0.007
Brugia malayi Bromodomain containing protein 0.0076 0.2696 0.2895
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0065 0.0284
Schistosoma mansoni zinc finger protein 0.002 0.0424 0.186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0356 0.0356
Trypanosoma cruzi ISWI complex protein 0.0016 0.0249 0.1031
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.9314 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.2417 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0065 0.007
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0356 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0065 0.007
Leishmania major cathepsin L-like protease 0.0018 0.0356 0.0491
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0356 0.0356
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.1599 0.1717
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.093 0.4075
Brugia malayi ecdysteroid receptor 0.0011 0.0065 0.007
Loa Loa (eye worm) hypothetical protein 0.0041 0.1292 0.1326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0356 0.0356
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0065 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.2417 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0356 0.0382
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.2282 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0356 0.0356
Loa Loa (eye worm) fibroinase 0.0018 0.0356 0.0314
Brugia malayi PHD-finger family protein 0.0025 0.0643 0.069
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0321 0.0345
Onchocerca volvulus 0.0018 0.0356 0.0293
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0356 0.0382
Brugia malayi Cathepsin L-like precursor 0.0018 0.0356 0.0382
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.2069 0.2221
Onchocerca volvulus 0.0049 0.1599 0.1544
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0356 0.0356
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0065 0.0284
Echinococcus multilocularis cysteine protease 0.0018 0.0356 0.0382
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0356 0.0314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.2417 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0065 0.007
Leishmania major cathepsin L-like protease 0.0018 0.0356 0.0491
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0065 0.0284
Plasmodium vivax SET domain protein, putative 0.0032 0.093 1
Echinococcus granulosus cathepsin l1 0.0018 0.0356 0.0382
Leishmania major cathepsin L-like protease 0.0018 0.0356 0.0491
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0065 0.007
Onchocerca volvulus 0.0032 0.093 0.0871
Loa Loa (eye worm) hypothetical protein 0.0012 0.0113 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0356 0.0356
Schistosoma mansoni bromodomain containing protein 0.0064 0.2216 0.9708
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0356 0.0293
Loa Loa (eye worm) hypothetical protein 0.0072 0.2521 0.2655
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.2417 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0356 0.0356
Brugia malayi hypothetical protein 0.024 0.9314 1
Brugia malayi Bromodomain containing protein 0.0039 0.1192 0.128
Onchocerca volvulus 0.0018 0.0356 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0065 0.007
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0356 0.1558
Brugia malayi Cathepsin L-like precursor 0.0018 0.0356 0.0382
Trichomonas vaginalis set domain proteins, putative 0.0257 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0065 0.007
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0356 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0356 0.0356
Onchocerca volvulus 0.0018 0.0356 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0065 0.007
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0113 0.0122
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0065 0.0284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.2417 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0356 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0356 0.0356
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0065 0.0284
Plasmodium vivax vivapain-2 0.0018 0.0356 0.3825
Onchocerca volvulus 0.0018 0.0356 0.0293
Plasmodium vivax vivapain-2 0.0018 0.0356 0.3825
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.2417 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0065 0.007
Echinococcus granulosus survival motor neuron protein 1 0.024 0.9314 1
Brugia malayi Pre-SET motif family protein 0.0032 0.093 0.0998
Onchocerca volvulus 0.0018 0.0356 0.0293
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0065 0.0284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0356 0.0356
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.2282 0.245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.2417 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0321 0.1407
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.1819 0.7525
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0065 0.007
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0065 0.007
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0356 0.0382
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0065 0.0284
Leishmania major cathepsin L-like protease 0.0069 0.2417 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0065 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0065 0.007
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0065 0.007
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0356 0.0491
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0065 0.007
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0113 0.0496
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.1095 0.1175
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.2417 1
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0065 0.007
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0468 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0065 0.007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0065 0.007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0065 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.2417 1
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0346 0.0304
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0065 0.007
Brugia malayi Cathepsin L-like precursor 0.0012 0.0113 0.0122
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0546 0.2393
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.1629 0.1749
Entamoeba histolytica cysteine protease, putative 0.0018 0.0356 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0356 0.0314
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0546 0.0586
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.2282 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0356 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0356 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0356 0.0356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0356 0.0356
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0065 0.007
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0321 0.0345
Brugia malayi Cathepsin L-like precursor 0.0018 0.0356 0.0382
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.093 0.0998
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0356 0.0356
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0065 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.2417 1
Onchocerca volvulus 0.0012 0.0113 0.0049
Brugia malayi steroid hormone receptor 0.0011 0.0065 0.007
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0065 0.0284
Schistosoma mansoni hypothetical protein 0.0016 0.0249 0.1092
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0356 0.0293
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.2282 0.5
Brugia malayi Cathepsin L-like precursor 0.0018 0.0356 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0356 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0113 0.0113
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.2282 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.093 0.4075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0065 0.007
Trypanosoma brucei ISWI complex protein 0.0016 0.0249 0.1031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.1629 0.7137
Onchocerca volvulus 0.0018 0.0356 0.0293
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0356 0.0382
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.2417 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0043 0.137 0.1411
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0065 0.007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0356 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.024 0.9314 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0065 0.0284

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 25 nM Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay ChEMBL. 22197390
IC50 (binding) = 324 nM Displacement of [125]-hNPW23 from human NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay ChEMBL. 22197390
IC50 (functional) = 360 nM Antagonist activity at mouse NPBWR1 expressed in CHO-K1 cells assessed as inhibition of hNPW23 and forskolin-stimulated cAMP production after 1 hr by TR-FRET assay ChEMBL. 22197390
IC50 (functional) = 1925 nM Antagonist activity at human NPBWR1 expressed in CHO-K1 cells assessed as inhibition of hNPW23 and forskolin-stimulated cAMP production after 1 hr by TR-FRET assay ChEMBL. 22197390
Stability (ADMET) = 0 % Metabolic stability in mouse liver microsomes assessed as compound remaining after 30 mins ChEMBL. 22197390

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.