Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0135 | 0.3248 | 0.2852 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor kainate | 0.0154 | 0.3943 | 0.3589 |
Echinococcus granulosus | glutamate receptor 2 | 0.0111 | 0.2376 | 0.193 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0135 | 0.3248 | 0.2852 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0173 | 0.464 | 0.4326 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0111 | 0.2376 | 0.193 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0173 | 0.464 | 0.4326 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0079 | 0.1174 | 0.0657 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0154 | 0.3943 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0173 | 0.464 | 0.4326 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0077 | 0.1101 | 0.058 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0154 | 0.3943 | 0.3589 |
Brugia malayi | Carboxylesterase family protein | 0.0135 | 0.3248 | 0.7552 |
Loa Loa (eye worm) | carboxylesterase | 0.0135 | 0.3248 | 0.7552 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0077 | 0.1101 | 0.058 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3248 | 0.7552 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0081 | 0.1249 | 0.0737 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3248 | 0.7552 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0077 | 0.1101 | 0.058 |
Echinococcus multilocularis | acetylcholinesterase | 0.0135 | 0.3248 | 0.2852 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0159 | 0.4133 | 0.379 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0077 | 0.1101 | 0.058 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0319 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0154 | 0.3943 | 0.3589 |
Echinococcus granulosus | glutamate receptor 2 | 0.0173 | 0.464 | 0.4326 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0154 | 0.3943 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0173 | 0.464 | 0.4326 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0077 | 0.1101 | 0.058 |
Schistosoma mansoni | glutamate receptor kainate | 0.0154 | 0.3943 | 0.3589 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0154 | 0.3943 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0077 | 0.1101 | 0.058 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0077 | 0.1101 | 0.058 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0173 | 0.464 | 0.4326 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0079 | 0.1174 | 0.0657 |
Echinococcus multilocularis | geminin | 0.0169 | 0.4486 | 0.4164 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0077 | 0.1101 | 0.058 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0319 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.4486 | 0.4164 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0098 | 0.187 | 0.1394 |
Brugia malayi | Carboxylesterase family protein | 0.0135 | 0.3248 | 0.7552 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.4486 | 0.4164 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0154 | 0.3943 | 0.3589 |
Schistosoma mansoni | glutamate receptor kainate | 0.0154 | 0.3943 | 0.3589 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0173 | 0.464 | 0.4326 |
Echinococcus multilocularis | acetylcholinesterase | 0.0135 | 0.3248 | 0.2852 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0159 | 0.4133 | 0.379 |
Echinococcus granulosus | acetylcholinesterase | 0.0135 | 0.3248 | 0.2852 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0173 | 0.464 | 0.4326 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0135 | 0.3248 | 0.7552 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0154 | 0.3943 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0098 | 0.187 | 0.1394 |
Schistosoma mansoni | voltage-gated cation channel | 0.0077 | 0.1101 | 0.058 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0077 | 0.1101 | 0.058 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0077 | 0.1101 | 0.058 |
Echinococcus granulosus | geminin | 0.0169 | 0.4486 | 0.4164 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0173 | 0.464 | 0.4326 |
Echinococcus granulosus | carboxylesterase 5A | 0.0135 | 0.3248 | 0.2852 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0154 | 0.3943 | 0.3589 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0252 | 0.7524 | 0.7379 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0173 | 0.464 | 0.4326 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0077 | 0.1101 | 0.058 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0135 | 0.3248 | 0.2852 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0077 | 0.1101 | 0.058 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 ratio (binding) | Transcriptional activation activity against retinoic acid receptor RAR alpha; Not active | ChEMBL. | No reference | |
EC50 ratio (binding) | = 5.6 | Transactivation activity at retinoic acid receptor gamma. | ChEMBL. | No reference |
EC50 ratio (binding) | = 100 | Transactivation activity at retinoic acid receptor beta. | ChEMBL. | No reference |
EC50 ratio (binding) | 0 | Transcriptional activation activity against retinoic acid receptor RAR alpha; Not active | ChEMBL. | No reference |
EC50 ratio (binding) | = 5.6 | Transactivation activity at retinoic acid receptor gamma. | ChEMBL. | No reference |
EC50 ratio (binding) | = 100 | Transactivation activity at retinoic acid receptor beta. | ChEMBL. | No reference |
Max (binding) | = 0 % | Maximum retinoic acid receptor (RAR)-alpha transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 0 % | Maximum retinoic acid receptor (RAR)-alpha transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 82 % | Maximum RAR-gamma transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 82 % | Maximum RAR-gamma transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 96 % | Maximum retinoic acid receptor (RAR)-beta transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 96 % | Maximum retinoic acid receptor (RAR)-beta transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.