Detailed information for compound 1595320

Basic information

Technical information
  • TDR Targets ID: 1595320
  • Name: 2-(1-adamantyl)ethyl 2-[5-(2-hydroxyethyl)-4- methyl-1,3-thiazol-3-ium-3-yl]acetate
  • MW: 364.522 | Formula: C20H30NO3S+
  • H donors: 1 H acceptors: 2 LogP: 4.93 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCc1sc[n+](c1C)CC(=O)OCCC12CC3CC(C2)CC(C1)C3
  • InChi: 1S/C20H30NO3S/c1-14-18(2-4-22)25-13-21(14)12-19(23)24-5-3-20-9-15-6-16(10-20)8-17(7-15)11-20/h13,15-17,22H,2-12H2,1H3/q+1
  • InChiKey: XQSZWVWBICKMOJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(1-adamantyl)ethyl 2-[5-(2-hydroxyethyl)-4-methyl-thiazol-3-ium-3-yl]acetate
  • 2-[5-(2-hydroxyethyl)-4-methyl-3-thiazol-3-iumyl]acetic acid 2-(1-adamantyl)ethyl ester
  • 2-[5-(2-hydroxyethyl)-4-methyl-thiazol-3-ium-3-yl]acetic acid 2-(1-adamantyl)ethyl ester
  • 2-(1-adamantyl)ethyl 2-[5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium-3-yl]ethanoate
  • ZINC05603480

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0047
Echinococcus granulosus death domain containing protein 0.0016 0.0016 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0056
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.0499 0.1386
Trypanosoma brucei heat shock protein 90, putative 0.0076 0.0342 0.0937
Echinococcus granulosus endoplasmin 0.0061 0.0258 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0147 0.0726 0.2032
Brugia malayi hypothetical protein 0.0027 0.0078 0.0222
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0064 0.0144
Loa Loa (eye worm) hypothetical protein 0.0147 0.0726 0.2032
Leishmania major DNA polymerase eta, putative 0.0047 0.0183 0.0484
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.005 0.0102
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.0183 0.1145
Schistosoma mansoni flap endonuclease-1 0.0026 0.0068 0.0074
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0093 0.0225
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0663 0.3518 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0078 0.0183
Toxoplasma gondii heat shock protein 75, putative 0.0031 0.0099 0.0574
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.0966 0.1047
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0092 0.0085
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0064 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0083 0.0197
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0173 0.0455
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Schistosoma mansoni microtubule-associated protein tau 0.0709 0.3767 0.4085
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.016 0.0418
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0966 0.7486
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0264 0.474
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.0305 0.0317
Brugia malayi photoreceptor-specific nuclear receptor 0.0147 0.0726 0.2064
Trichomonas vaginalis ferritin, putative 0.0027 0.0075 0.0485
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0078 0.1957
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.005 0.0141
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0264 0.0714
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0033 0.0601
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0191 0.0966 0.2716
Loa Loa (eye worm) TAR-binding protein 0.0207 0.1051 0.2959
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0031 0.0099 0.0243
Brugia malayi nuclear hormone receptor family member odr-7 0.0069 0.0305 0.0868
Echinococcus multilocularis snurportin 1 0.0321 0.1668 0.1797
Plasmodium falciparum endoplasmin, putative 0.0047 0.0183 0.5145
Schistosoma mansoni ferritin 0.0027 0.0075 0.0082
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0025 0.0011
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.003 0.0501
Schistosoma mansoni apoferritin-2 0.0027 0.0075 0.0082
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0061 0.0258 0.0266
Schistosoma mansoni ferritin 0.0027 0.0075 0.0082
Schistosoma mansoni hypothetical protein 0.1716 0.9219 1
Mycobacterium ulcerans hypothetical protein 0.0019 0.0033 0.0374
Onchocerca volvulus 0.0251 0.1286 1
Echinococcus multilocularis endoplasmin 0.0061 0.0258 0.0266
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0147 0.0726 0.0774
Schistosoma mansoni heat shock protein 0.0076 0.0342 0.0371
Brugia malayi RNA binding protein 0.0207 0.1051 0.2987
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0093 0.0225
Trypanosoma cruzi Heat shock protein 83, putative 0.0076 0.0342 0.0937
Trypanosoma cruzi DNA repair protein, putative 0.0035 0.0118 0.0298
Brugia malayi CXXC zinc finger family protein 0.015 0.0742 0.2108
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0083 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Trypanosoma brucei unspecified product 0.0043 0.016 0.0418
Schistosoma mansoni DNA topoisomerase II 0.0016 0.0014 0.0015
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0083 0.2107
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0147 0.0726 0.0788
Treponema pallidum recombinase A 0.0113 0.0542 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0147 0.0726 0.0774
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0114 0.0786
Schistosoma mansoni heat shock protein 0.0031 0.0099 0.0107
Brugia malayi heat shock protein 90 0.0076 0.0342 0.0973
Plasmodium vivax heat shock protein 90, putative 0.0031 0.0099 0.2588
Echinococcus multilocularis protein dispatched 1 0.0052 0.0209 0.0212
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0147 0.0726 0.0774
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0016 0.0002
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0116 0.0111
Brugia malayi ecdysone receptor 0.0069 0.0305 0.0868
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0114 0.0786
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0033 0.0056
Loa Loa (eye worm) nuclear hormone receptor 0.0069 0.0305 0.0832
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0147 0.0726 0.2064
Schistosoma mansoni cpg binding protein 0.0159 0.0788 0.0855
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Onchocerca volvulus 0.0147 0.0726 0.5646
Leishmania major DNA polymerase kappa, putative 0.0019 0.0033 0.0056
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0033 0.0036
Echinococcus multilocularis geminin 0.0371 0.194 0.2093
Brugia malayi ImpB/MucB/SamB family protein 0.0089 0.0414 0.1176
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0178 0.1112
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0038 0.0138 0.0135
Entamoeba histolytica heat shock protein 90, putative 0.0076 0.0342 0.0937
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0078 0.035 0.038
Loa Loa (eye worm) hypothetical protein 0.0147 0.0726 0.2032
Trichomonas vaginalis heat shock protein, putative 0.0076 0.0342 0.2583
Loa Loa (eye worm) hypothetical protein 0.0069 0.0305 0.0832
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0178 0.1295
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0033 0.0056
Echinococcus granulosus thyroid hormone receptor alpha 0.0069 0.0305 0.0317
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0113 0.0542 0.1506
Loa Loa (eye worm) hypothetical protein 0.0147 0.0726 0.2032
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0443 0.3372
Loa Loa (eye worm) hypothetical protein 0.0147 0.0726 0.2032
Mycobacterium ulcerans heat shock protein 90 0.0061 0.0258 0.4631
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.0964 0.1032
Chlamydia trachomatis recombinase RecA 0.0113 0.0542 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0116 0.0126
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0114 0.0786
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0069 0.0305 0.0331
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0187 0.0944 0.1011
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0147 0.0726 0.0788
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0319 0.1658 0.1798
Brugia malayi Nuclear hormone receptor-like 1 0.0147 0.0726 0.2064
Trichomonas vaginalis set domain proteins, putative 0.025 0.1285 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0147 0.0726 0.0788
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.005 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0147 0.0726 0.2032
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.1668 0.4721
Schistosoma mansoni nuclear receptor 0.0069 0.0305 0.0331
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0264 0.0714
Brugia malayi orphan nuclear receptor NR2E1 0.0069 0.0305 0.0868
Loa Loa (eye worm) hypothetical protein 0.0069 0.0305 0.0832
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.0183
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0147 0.0726 0.0774
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0114 0.0786
Brugia malayi Endoplasmin precursor 0.0076 0.0342 0.0973
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0114 0.0786
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0966 0.7486
Brugia malayi Nuclear hormone receptor E75 0.0069 0.0305 0.0868
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0078 0.0183
Leishmania major hypothetical protein, conserved 0.0027 0.0078 0.0183
Echinococcus multilocularis expressed conserved protein 0.0099 0.0465 0.049
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0114 0.0786
Schistosoma mansoni nuclear hormone receptor 0.0069 0.0305 0.0331
Brugia malayi Flap endonuclease-1 0.0028 0.0083 0.0236
Trichomonas vaginalis helicase, putative 0.0034 0.0114 0.0786
Brugia malayi Importin beta-1 subunit 0.003 0.0093 0.0263
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0114 0.0786
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0147 0.0726 0.0774
Brugia malayi nuclear hormone receptor 0.0147 0.0726 0.2064
Entamoeba histolytica hypothetical protein 0.0018 0.0026 0.0034
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0663 0.3518 0.3816
Trichomonas vaginalis heat shock protein, putative 0.0061 0.0258 0.1922
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0064 0.0955
Plasmodium vivax heat shock protein 86, putative 0.0076 0.0342 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0663 0.3518 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0414 0.1141
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0028 0.0116
Plasmodium falciparum heat shock protein 90, putative 0.0031 0.0099 0.2588
Schistosoma mansoni hypothetical protein 0.0044 0.0165 0.0179
Brugia malayi F/Y-rich N-terminus family protein 0.0047 0.0184 0.0523
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0033 0.0056
Loa Loa (eye worm) hypothetical protein 0.0034 0.0116 0.0292
Schistosoma mansoni thyroid hormone receptor 0.0147 0.0726 0.0788
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.0144
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0083 0.0197
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0064 0.0182
Brugia malayi nuclear receptor NHR-88 0.0069 0.0305 0.0868
Brugia malayi Nuclear hormone receptor-like 1 0.0078 0.035 0.0996
Echinococcus granulosus importin subunit beta 1 0.003 0.0093 0.0086
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0147 0.0726 0.0774
Loa Loa (eye worm) hypothetical protein 0.0078 0.035 0.0961
Schistosoma mansoni kinase 0.0097 0.0456 0.0495
Onchocerca volvulus 0.0025 0.0064 0.0499
Echinococcus multilocularis protein patched 0.0045 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0069 0.0305 0.0832
Schistosoma mansoni heat shock protein 0.0076 0.0342 0.0371
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0061 0.0258 0.0697
Plasmodium vivax heat shock protein, putative 0.0031 0.0099 0.2588
Leishmania major GTP-binding protein, putative 0.0022 0.005 0.0102
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0966 0.7486
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0016 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.016 0.0418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0147 0.0726 0.2032
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0663 0.3518 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.0726 0.2032
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0069 0.0305 0.0317
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0033 0.0056
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0052 0.0057
Plasmodium falciparum heat shock protein 90, putative 0.0031 0.0099 0.2588
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0114 0.0786
Loa Loa (eye worm) DR-78 0.0069 0.0305 0.0832
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0033 0.0133
Schistosoma mansoni nuclear hormone receptor 0.0069 0.0305 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0015 0.001
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0031 0.0099 0.0092
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.1123 0.3165
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0083 0.0197
Echinococcus multilocularis transcription factor Dp 1 0.0384 0.2007 0.2165
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Loa Loa (eye worm) hypothetical protein 0.0055 0.0229 0.0615
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Brugia malayi hypothetical protein 0.0078 0.035 0.0996
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Echinococcus granulosus nuclear receptor nhr 48 0.0069 0.0305 0.0317
Onchocerca volvulus Protein ultraspiracle homolog 0.0147 0.0726 0.5646
Trypanosoma cruzi heat shock protein, putative 0.0031 0.0099 0.0243
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0069 0.0305 0.0331
Echinococcus multilocularis expressed protein 0.0027 0.0075 0.0067
Entamoeba histolytica deoxycytidyl transferase, putative 0.0062 0.0264 0.0714
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0147 0.0726 0.2032
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0147 0.0726 0.5646
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0064 0.0955
Echinococcus multilocularis dna polymerase kappa 0.0062 0.0264 0.0272
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1079 0.5771 0.6254
Brugia malayi kinase, mitochondrial precursor 0.0016 0.0014 0.0039
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.0775 0.2204
Echinococcus multilocularis FTZ F1 alpha 0.0147 0.0726 0.0774
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0158 0.4383
Loa Loa (eye worm) hypothetical protein 0.0105 0.0499 0.1386
Loa Loa (eye worm) hypothetical protein 0.0069 0.0305 0.0832
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Trypanosoma brucei heat shock protein, putative 0.0076 0.0342 0.0937
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0062 0.0264 0.0286
Schistosoma mansoni tar DNA-binding protein 0.0207 0.1051 0.114
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Entamoeba histolytica serine/threonine protein kinase, putative 0.0191 0.0966 0.2716
Echinococcus multilocularis Niemann Pick C1 protein 0.015 0.0744 0.0793
Echinococcus multilocularis tar DNA binding protein 0.0207 0.1051 0.1127
Trypanosoma cruzi ISWI complex protein 0.0016 0.0015 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.0305 0.0317
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0038 0.0138 0.0135
Echinococcus granulosus mixed lineage leukemia protein mll 0.0038 0.0138 0.0135
Brugia malayi serine/threonine-protein kinase plk-2 0.0191 0.0966 0.2745
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0027 0.0075 0.1168
Brugia malayi Hsp90 protein 0.0031 0.0099 0.0281
Schistosoma mansoni apoferritin-2 0.0027 0.0075 0.0082
Echinococcus granulosus Niemann Pick C1 protein 0.015 0.0744 0.0793
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0069 0.0305 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0147 0.0726 0.2064
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0016 0.0014 0.0107
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0061 0.0258 0.4631
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0062 0.0378
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0033 0.0056
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0062 0.0264 0.0714
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0138 0.0149
Trypanosoma brucei heat shock protein 90, putative 0.0076 0.0342 0.0937
Trypanosoma brucei heat shock protein, putative 0.0076 0.0342 0.0937
Leishmania major heat shock protein, putative 0.0031 0.0099 0.0243
Schistosoma mansoni nuclear hormone receptor 0.0147 0.0726 0.0788
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Schistosoma mansoni hypothetical protein 0.0321 0.1668 0.1809
Brugia malayi polk-prov protein 0.0019 0.0033 0.0095
Trypanosoma cruzi DNA polymerase eta, putative 0.0089 0.0414 0.1141
Schistosoma mansoni myst-related protein 0.0018 0.0026 0.0028
Schistosoma mansoni DNA polymerase eta 0.0089 0.0414 0.0449
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0064 0.0955
Schistosoma mansoni terminal deoxycytidyl transferase 0.0062 0.0264 0.0286
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0147 0.0726 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0114 0.0786
Echinococcus multilocularis dna polymerase eta 0.0089 0.0414 0.0435
Schistosoma mansoni hypothetical protein 0.0371 0.194 0.2105
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0966 0.7486
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.0144
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.0144
Echinococcus granulosus heat shock protein 0.0076 0.0342 0.0357
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0015 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0147 0.0726 0.0774
Brugia malayi hypothetical protein 0.0069 0.0305 0.0868
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.003 0.0312
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0064 0.0051
Loa Loa (eye worm) hypothetical protein 0.0069 0.0305 0.0832
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0064 0.0144
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.005 0.0039
Entamoeba histolytica Ran family GTPase 0.0022 0.005 0.0102
Brugia malayi Death domain containing protein 0.0016 0.0016 0.0045
Echinococcus multilocularis nuclear receptor nhr 48 0.0069 0.0305 0.0317
Trypanosoma brucei unspecified product 0.0062 0.0264 0.0714
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0964 0.1046
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Loa Loa (eye worm) histone methyltransferase 0.0048 0.0187 0.0495
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0064 0.0144
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0069 0.0305 0.0832
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0078 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0207 0.1051 0.114
Brugia malayi RNA, U transporter 1 0.0086 0.0393 0.1117
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0147 0.0726 0.0774
Plasmodium falciparum zinc finger protein, putative 0.0018 0.0026 0.0359
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.166 0.8917 0.9671
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0147 0.0726 0.0788
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.003 0.0501
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0083 0.0197
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0966 0.7486
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0016 0.0014 0.0039
Loa Loa (eye worm) heat shock protein 90 0.0076 0.0342 0.0937
Trypanosoma cruzi heat shock protein 90, putative 0.0061 0.0258 0.0697
Trichomonas vaginalis DNA polymerase eta, putative 0.0062 0.0264 0.1968
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.005 0.0102
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0069 0.0305 0.0317
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0033 0.0056
Loa Loa (eye worm) hypothetical protein 0.0147 0.0726 0.2032
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0114 0.0786
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0147 0.0726 0.2064
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0016 0.0123
Brugia malayi Nuclear hormone receptor E75 0.0069 0.0305 0.0868
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Schistosoma mansoni cpg binding protein 0.015 0.0742 0.0804
Schistosoma mansoni nuclear receptor nhr-48 0.0069 0.0305 0.0331
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0147 0.0726 0.2064
Schistosoma mansoni hypothetical protein 0.0044 0.0165 0.0179
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.003 0.0016
Echinococcus granulosus heat shock protein 90 0.0076 0.0342 0.0357
Loa Loa (eye worm) RNA binding protein 0.0207 0.1051 0.2959
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0147 0.0726 0.2032
Schistosoma mansoni ran 0.0022 0.005 0.0054
Schistosoma mansoni ran 0.0022 0.005 0.0054
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0033 0.0056
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0147 0.0726 0.0788
Loa Loa (eye worm) hypothetical protein 0.0069 0.0305 0.0832
Plasmodium falciparum heat shock protein 90 0.0076 0.0342 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0064 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0147 0.0726 0.2032
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0028 0.0116
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0016 0.0014 0.0107
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0663 0.3518 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.015 0.0742 0.2077
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0114 0.0786
Trichomonas vaginalis heat shock protein, putative 0.0061 0.0258 0.1922
Schistosoma mansoni importin beta-1 0.003 0.0093 0.01
Brugia malayi hypothetical protein 0.0069 0.0305 0.0868
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0116 0.0691
Echinococcus granulosus cpg binding protein 0.0159 0.0788 0.0841
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0174 0.0174
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0078 0.035 0.0366
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0114 0.0786
Echinococcus granulosus retinoic acid receptor rxr beta a 0.1157 0.6192 0.6711
Schistosoma mansoni myst-related protein 0.0018 0.0026 0.0028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0025 0.0011
Trypanosoma cruzi heat shock protein 85, putative 0.0076 0.0342 0.0937
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0069 0.0305 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0147 0.0726 0.2064
Loa Loa (eye worm) hypothetical protein 0.0147 0.0726 0.2032
Brugia malayi RNA recognition motif domain containing protein 0.0207 0.1051 0.2987
Trypanosoma brucei ISWI complex protein 0.0016 0.0015 0.0004
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0078 0.035 0.0961
Onchocerca volvulus Bile acid receptor homolog 0.0147 0.0726 0.5646
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0062 0.0378
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0264 0.474
Brugia malayi hypothetical protein 0.0018 0.0025 0.0072
Entamoeba histolytica hypothetical protein 0.0187 0.0944 0.2655
Echinococcus granulosus expressed protein 0.0027 0.0075 0.0067
Trypanosoma cruzi polo-like protein kinase, putative 0.0191 0.0966 0.2716
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.0499 0.0528
Mycobacterium ulcerans hypothetical protein 0.0025 0.0064 0.0955
Brugia malayi Nuclear hormone receptor-like 1 0.0078 0.035 0.0996
Trichomonas vaginalis endoplasmin, putative 0.0047 0.0183 0.1329
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0047
Echinococcus multilocularis Ankyrin 0.0016 0.0017 0.0003
Echinococcus granulosus geminin 0.0371 0.194 0.2093
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Toxoplasma gondii Hsp90 domain-containing protein 0.0031 0.0099 0.0574
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0078 0.035 0.0366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0147 0.0726 0.2032
Brugia malayi TAR-binding protein 0.0207 0.1051 0.2987
Toxoplasma gondii heat shock protein HSP90 0.0076 0.0342 0.2217
Loa Loa (eye worm) endoplasmin 0.0076 0.0342 0.0937
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.005 0.0102
Echinococcus granulosus Nuclear hormone receptor HR96 0.0069 0.0305 0.0317
Brugia malayi CHE-14 protein 0.0045 0.0174 0.0495
Echinococcus multilocularis ecdysone induced protein 78C 0.0147 0.0726 0.0774
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0025 0.0011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.003 0.0312
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0062 0.0264 0.1968
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0061 0.0258 0.0697
Trypanosoma cruzi heat shock protein 85, putative 0.0076 0.0342 0.0937
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.005 0.1092
Plasmodium vivax SET domain protein, putative 0.0034 0.0116 0.3116
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0078 0.0434
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0964 0.1046
Schistosoma mansoni tar DNA-binding protein 0.0207 0.1051 0.114
Trichomonas vaginalis heat shock protein, putative 0.0061 0.0258 0.1922
Trypanosoma cruzi heat shock protein 90, putative 0.0076 0.0342 0.0937
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.0775 0.0841
Entamoeba histolytica hypothetical protein 0.0187 0.0944 0.2655
Echinococcus multilocularis heat shock protein 0.0076 0.0342 0.0357
Schistosoma mansoni nuclear receptor 0.0069 0.0305 0.0331
Echinococcus multilocularis cpg binding protein 0.0159 0.0788 0.0841
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0047
Loa Loa (eye worm) hypothetical protein 0.0078 0.035 0.0961
Trypanosoma brucei unspecified product 0.0043 0.016 0.0418
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0158 0.1512
Schistosoma mansoni hypothetical protein 0.0044 0.0165 0.0179
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Mycobacterium ulcerans bacterioferritin BfrB 0.0027 0.0075 0.1168
Plasmodium falciparum flap endonuclease 1 0.0028 0.0083 0.2107
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.0775 0.0827
Brugia malayi nuclear receptor NHR-67 0.0069 0.0305 0.0868
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0025 0.0011
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.037 0.0387
Entamoeba histolytica hypothetical protein 0.0187 0.0944 0.2655
Loa Loa (eye worm) steroid hormone receptor 0.0147 0.0726 0.2032
Onchocerca volvulus Serine\/threonine kinase homolog 0.0191 0.0966 0.7509
Giardia lamblia Grp94/Hsp90 0.0061 0.0258 0.2568
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0064 0.0955
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0083 0.0467
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.0964 0.274
Loa Loa (eye worm) nuclear receptor NHR-67 0.0069 0.0305 0.0832
Schistosoma mansoni zinc finger protein 0.0069 0.0305 0.0331
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0116 0.0126
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0016 0.0002
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.0752 0.0802
Brugia malayi Uncoordinated protein 44 0.0016 0.0016 0.0045
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0147 0.0726 0.2064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0116 0.0126
Brugia malayi Pre-SET motif family protein 0.0034 0.0116 0.033
Echinococcus multilocularis microtubule associated protein 2 0.0709 0.3767 0.4077
Trypanosoma cruzi polo-like protein kinase, putative 0.0191 0.0966 0.2716
Echinococcus granulosus ecdysone induced protein 78C 0.0147 0.0726 0.0774
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0093 0.0532
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0147 0.0726 0.2064
Echinococcus granulosus transcription factor Dp 1 0.0384 0.2007 0.2165
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0083 0.0727
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0207 0.1051 0.2959
Echinococcus granulosus dna polymerase eta 0.0089 0.0414 0.0435
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.0964 0.2712
Schistosoma mansoni retinoic acid receptor RXR 0.1157 0.6192 0.6716
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0443 0.3372
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0663 0.3518 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0178 0.5014
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0078 0.1957
Echinococcus granulosus Nuclear hormone receptor HR96 0.0069 0.0305 0.0317
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.0508 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0147 0.0726 0.2064
Echinococcus multilocularis dnaJ subfamily B 0.1716 0.9219 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0083 0.0197
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0062 0.0264 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0147 0.0726 0.2064
Echinococcus multilocularis importin subunit beta 1 0.003 0.0093 0.0086
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0225
Loa Loa (eye worm) acetyltransferase 0.0156 0.0775 0.2173
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0178 0.1112
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0033 0.0056
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.016 0.0418
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0064 0.0955
Brugia malayi hypothetical protein 0.0187 0.0944 0.2683
Loa Loa (eye worm) hypothetical protein 0.0069 0.0305 0.0832
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0187 0.0944 0.1011
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0966 0.7486
Brugia malayi Steroid receptor seven-up type 2 0.0147 0.0726 0.2064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0114 0.0786
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0033 0.0056
Brugia malayi nuclear receptor NHR-88 0.0147 0.0726 0.2064
Giardia lamblia Kinase, PLK 0.0191 0.0966 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0183 0.0484
Treponema pallidum heat shock protein 90 0.0061 0.0258 0.4631
Schistosoma mansoni RAR-like nuclear receptor 0.0147 0.0726 0.0788
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0016 0.0014 0.0039
Schistosoma mansoni hypothetical protein 0.0371 0.194 0.2105
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0183 0.1329
Toxoplasma gondii heat shock protein 90, putative 0.0076 0.0342 0.2217
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0099 0.0668
Plasmodium falciparum importin beta, putative 0.003 0.0093 0.2401
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.0499 0.142
Echinococcus multilocularis heat shock protein 90 0.0076 0.0342 0.0357
Leishmania major heat shock protein 83-1 0.0076 0.0342 0.0937
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0113 0.0542 1
Trypanosoma brucei heat shock protein 84, putative 0.0031 0.0099 0.0243
Toxoplasma gondii histone lysine methyltransferase SET1 0.0289 0.1495 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0064 0.0144
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0016 0.0006
Echinococcus granulosus FTZ F1 alpha 0.0147 0.0726 0.0774
Trypanosoma brucei heat shock protein, putative 0.0076 0.0342 0.0937
Brugia malayi nuclear hormone receptor 0.0069 0.0305 0.0868
Schistosoma mansoni steroid hormone receptor ad4bp 0.0147 0.0726 0.0788
Brugia malayi nuclear receptor RXR 0.0069 0.0305 0.0868
Echinococcus granulosus expressed conserved protein 0.0099 0.0465 0.049
Loa Loa (eye worm) hypothetical protein 0.0069 0.0305 0.0832
Loa Loa (eye worm) hypothetical protein 0.0069 0.0305 0.0832
Trypanosoma brucei heat shock protein, putative 0.0076 0.0342 0.0937
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.005 0.1092
Loa Loa (eye worm) hypothetical protein 0.0045 0.0174 0.0458
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1747 0.9388 0.9387
Loa Loa (eye worm) hypothetical protein 0.0078 0.035 0.0961
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0147 0.0726 0.0774
Trypanosoma brucei heat shock protein, putative 0.0076 0.0342 0.0937
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0064 0.0955
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0016 0.0014 0.0107
Brugia malayi nuclear hormone receptor family member nhr-6 0.0069 0.0305 0.0868
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0114 0.0786
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0031 0.0099 0.0092
Echinococcus granulosus snurportin 1 0.0321 0.1668 0.1797
Trichomonas vaginalis hypothetical protein 0.0018 0.0028 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0147 0.0726 0.2064
Schistosoma mansoni thyroid hormone receptor 0.0147 0.0726 0.0788
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Trypanosoma brucei heat shock protein, putative 0.0076 0.0342 0.0937
Brugia malayi Protein kinase domain containing protein 0.0017 0.0019 0.0054
Brugia malayi Probable DNA topoisomerase II 0.0016 0.0014 0.0039
Trichomonas vaginalis ran, putative 0.0022 0.005 0.0282
Echinococcus multilocularis heat shock protein 90 0.0061 0.0258 0.0266
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0191 0.0966 0.1034
Echinococcus granulosus tar DNA binding protein 0.0207 0.1051 0.1127
Trypanosoma brucei polo-like protein kinase 0.0191 0.0966 0.2716
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0016 0.0002
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0264 0.075
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0663 0.3518 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0061 0.0258 0.0245
Trypanosoma cruzi DNA repair protein, putative 0.0035 0.0118 0.0298
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0038 0.0138 0.0135
Giardia lamblia DNA damage repair protein 0.0019 0.0033 0.0207
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0178 0.1295
Schistosoma mansoni ferritin light chain 0.0027 0.0075 0.0082
Treponema pallidum bacterioferrin (TpF1) 0.0027 0.0075 0.1168
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0114 0.0786
Trypanosoma cruzi heat shock protein 85, putative 0.0061 0.0258 0.0697
Plasmodium vivax importin-beta 2, putative 0.003 0.0093 0.2401
Schistosoma mansoni cpg binding protein 0.0159 0.0788 0.0855
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0078 0.035 0.038
Echinococcus granulosus dnaJ subfamily B 0.1716 0.9219 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.037 0.0387
Echinococcus granulosus ferritin 0.0027 0.0075 0.0067
Schistosoma mansoni coup transcription factor 0.0147 0.0726 0.0788
Mycobacterium leprae Conserved hypothetical protein 0.0663 0.3519 1
Schistosoma mansoni hypothetical protein 0.0044 0.0165 0.0179
Loa Loa (eye worm) hypothetical protein 0.0069 0.0305 0.0832
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0191 0.0966 0.2716
Echinococcus multilocularis ferritin 0.0027 0.0075 0.0067
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0062 0.0378
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0178 0.0179
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0062 0.0264 0.0714
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0064 0.0051
Loa Loa (eye worm) hypothetical protein 0.0069 0.0305 0.0832
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0033 0.0133
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0174 0.0458
Schistosoma mansoni ferritin light chain 0.0027 0.0075 0.0082
Trypanosoma brucei Heat shock protein 83, putative 0.0076 0.0342 0.0937
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0174 0.0174
Onchocerca volvulus 0.0034 0.0116 0.0903
Loa Loa (eye worm) hypothetical protein 0.0078 0.035 0.0961
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0017 0.0018
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0069 0.0305 0.0868
Trypanosoma brucei DNA polymerase eta, putative 0.0089 0.0414 0.1141
Loa Loa (eye worm) hypothetical protein 0.0069 0.0305 0.0832
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0116 0.0126
Schistosoma mansoni netrin receptor unc5 0.0016 0.0016 0.0017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0048 0.0187 0.0188
Giardia lamblia Heat shock protein HSP 90-alpha 0.0061 0.0258 0.2568
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0191 0.0966 0.1034
Entamoeba histolytica hypothetical protein 0.0024 0.0062 0.0137
Echinococcus granulosus microtubule associated protein 2 0.0709 0.3767 0.4077
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0064 0.0955
Schistosoma mansoni patched 1 0.0045 0.0174 0.0189
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0116 0.0111
Brugia malayi conserved hypotetical protein 0.0069 0.0305 0.0868
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0027 0.0075 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.0964 0.1032
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0078 0.1957
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0147 0.0726 0.2064
Mycobacterium ulcerans recombinase A 0.0113 0.0542 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.0964 0.1032
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0016 0.0045
Entamoeba histolytica heat shock protein 90, putative 0.0076 0.0342 0.0937
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.005 0.0242
Onchocerca volvulus 0.015 0.0742 0.5767
Leishmania major importin beta-1 subunit, putative 0.0024 0.0062 0.0137
Brugia malayi hypothetical protein 0.0078 0.035 0.0996
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0047
Brugia malayi steroid hormone receptor 0.0147 0.0726 0.2064
Schistosoma mansoni hypothetical protein 0.0187 0.0944 0.1024
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0035 0.0118 0.0298
Brugia malayi tailless protein 0.0069 0.0305 0.0868
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0147 0.0726 0.0774
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0064 0.0144
Trypanosoma cruzi heat shock protein 85, putative 0.0076 0.0342 0.0937
Plasmodium vivax endoplasmin, putative 0.0076 0.0342 1
Schistosoma mansoni ferritin 0.0027 0.0075 0.0082
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0062 0.0264 0.0251
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0062 0.0137
Onchocerca volvulus 0.0069 0.0305 0.2375
Schistosoma mansoni endoplasmin 0.0076 0.0342 0.0371
Schistosoma mansoni pyruvate dehydrogenase 0.0016 0.0014 0.0015
Schistosoma mansoni endoplasmin 0.0076 0.0342 0.0371
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0174 0.0174
Schistosoma mansoni transcription factor LCR-F1 0.0187 0.0944 0.1024
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0016 0.0017
Onchocerca volvulus 0.0069 0.0305 0.2375
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0062 0.0264 0.0272
Loa Loa (eye worm) hypothetical protein 0.0147 0.0726 0.2032
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0663 0.3518 0.3807
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0207 0.1051 0.114
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.005 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0174 0.1262
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.0964 0.1032
Trypanosoma brucei heat shock protein, putative 0.0076 0.0342 0.0937
Leishmania major DNA damage repair protein, putative 0.0019 0.0033 0.0056
Brugia malayi ecdysteroid receptor 0.0147 0.0726 0.2064
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0033 0.0601
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0158 0.0411
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0147 0.0726 0.0788
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0015 0.001
Schistosoma mansoni ferritin 0.0027 0.0075 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0114 0.0786
Leishmania major DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Loa Loa (eye worm) hypothetical protein 0.0078 0.035 0.0961
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0663 0.3518 0.3807
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0663 0.3518 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0064 0.0144
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0147 0.0726 0.0774
Echinococcus granulosus Ankyrin 0.0016 0.0017 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0114 0.0786
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0147 0.0726 0.2064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0147 0.0726 0.0774
Leishmania major DNA polymerase eta, putative 0.0089 0.0414 0.1141
Mycobacterium ulcerans bacterioferritin BfrA 0.0027 0.0075 0.1168
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0966 0.7486
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0064 0.0182
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0017
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.005 0.0377
Brugia malayi nuclear receptor RXR 0.0078 0.035 0.0996
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0116 0.0111
Trypanosoma brucei heat shock protein, putative 0.0076 0.0342 0.0937
Echinococcus granulosus heat shock protein 90 0.0061 0.0258 0.0266
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0027 0.0075 0.0062
Entamoeba histolytica hypothetical protein 0.0187 0.0944 0.2655
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0027 0.0075 0.0176
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0964 0.1046
Giardia lamblia DINP protein human, muc B family 0.0062 0.0264 0.2628
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0264 0.0714
Loa Loa (eye worm) heat shock protein 75 0.0031 0.0099 0.0243
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0069 0.0305 0.2375
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0048 0.0187 0.0188
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 0.0264 0.0251
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0147 0.0726 0.2064
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0064 0.0144
Brugia malayi Pre-SET motif family protein 0.022 0.1123 0.3191
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0264 0.0714
Echinococcus granulosus flap endonuclease 1 0.0028 0.0083 0.0075
Echinococcus granulosus dna polymerase kappa 0.0062 0.0264 0.0272
Loa Loa (eye worm) hypothetical protein 0.0069 0.0305 0.0832
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.0499 0.0528
Schistosoma mansoni tar DNA-binding protein 0.0207 0.1051 0.114
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0033 0.0056
Giardia lamblia Heat shock protein HSP 90-alpha 0.0076 0.0342 0.345
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0031 0.0099 0.0768
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0033 0.0056
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0083 0.0544
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0069 0.0305 0.2375

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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