TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 453.365 | Formula: C20H26Cl2N6O2
H donors: 4 H acceptors: 2 LogP: 2.42 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)C(=N)N)NCCCCNC(=O)c1ccc(cc1)C(=N)N.Cl.Cl
InChi: 1S/C20H24N6O2.2ClH/c21-17(22)13-3-7-15(8-4-13)19(27)25-11-1-2-12-26-20(28)16-9-5-14(6-10-16)18(23)24;;/h3-10H,1-2,11-12H2,(H3,21,22)(H3,23,24)(H,25,27)(H,26,28);2*1H
InChiKey: JLRWPFPGGHJKPS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	DNA polymerase eta, putative	0.0031	0.0112	0.0182
Echinococcus granulosus	ecdysone induced protein 78C	0.0077	0.0549	0.0549
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.0165	0.0165
Echinococcus granulosus	FTZ F1 alpha	0.0077	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0549	0.0892
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0667	0.6153	0.6153
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0244	0.0244
Brugia malayi	conserved hypotetical protein	0.0036	0.0165	0.0268
Entamoeba histolytica	hypothetical protein	0.0035	0.0154	0.025
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0077	0.0549	0.0892
Schistosoma mansoni	hypothetical protein	0.0035	0.0154	0.0154
Echinococcus granulosus	transcription factor Dp 1	0.0386	0.3487	0.3487
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0268
Leishmania major	hypothetical protein, conserved	0.0024	0.0054	0.0088
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0077	0.0549	0.0571
Onchocerca volvulus		0.0077	0.0549	1
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0025	0.0062	0.0101
Brugia malayi	photoreceptor-specific nuclear receptor	0.0077	0.0549	0.0892
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0667	0.6153	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0077	0.0549	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0268
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0154	0.0154
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0406	0.0406
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0244	0.0253
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0406	0.0406
Brugia malayi	hypothetical protein	0.0036	0.0165	0.0268
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0154	0.016
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0036	0.0165	0.0165
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0036	0.0165	0.0171
Entamoeba histolytica	hypothetical protein	0.0035	0.0154	0.025
Schistosoma mansoni	coup transcription factor	0.0077	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0235	0.0382
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0	0.5
Trichomonas vaginalis	flap endonuclease-1, putative	0.0025	0.0062	1
Schistosoma mansoni	hypothetical protein	0.0165	0.1384	0.1384
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0667	0.6153	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0077	0.0549	0.0549
Schistosoma mansoni	thyroid hormone receptor	0.0077	0.0549	0.0549
Echinococcus granulosus	nuclear receptor nhr 48	0.0036	0.0165	0.0165
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0077	0.0549	0.0549
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0667	0.6153	1
Leishmania major	DNA polymerase eta, putative	0.0031	0.0112	0.0182
Brugia malayi	nuclear receptor RXR	0.004	0.0206	0.0335
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0054	0.0088
Brugia malayi	Nuclear hormone receptor-like 1	0.0077	0.0549	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0549	0.0892
Brugia malayi	ecdysteroid receptor	0.0077	0.0549	0.0892
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0077	0.0549	0.0892
Brugia malayi	hypothetical protein	0.004	0.0206	0.0335
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0077	0.0549	0.0892
Loa Loa (eye worm)	hypothetical protein	0.004	0.0206	0.0335
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.004	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0268
Brugia malayi	Nuclear hormone receptor-like 1	0.004	0.0206	0.0335
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0077	0.0549	0.0549
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0077	0.0549	0.0549
Entamoeba histolytica	hypothetical protein	0.0035	0.0154	0.025
Brugia malayi	Protein kinase domain containing protein	0.0231	0.201	0.3267
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0268
Schistosoma mansoni	nuclear receptor nhr-48	0.0036	0.0165	0.0165
Brugia malayi	nuclear hormone receptor	0.0036	0.0165	0.0268
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0036	0.0165	0.0268
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0406	0.066
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0244	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0549	0.0892
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0077	0.0549	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0036	0.0165	0.0165
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0667	0.6153	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.004	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0549	0.0892
Brugia malayi	Nuclear hormone receptor E75	0.0036	0.0165	0.0268
Echinococcus granulosus	thyroid hormone receptor alpha	0.0036	0.0165	0.0165
Brugia malayi	tailless protein	0.0036	0.0165	0.0268
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0077	0.0549	0.0892
Brugia malayi	nuclear hormone receptor	0.0077	0.0549	0.0892
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0077	0.0549	0.0549
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0036	0.0165	0.0165
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0268
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0244	0.0244
Schistosoma mansoni	RAR-like nuclear receptor	0.0077	0.0549	0.0549
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0036	0.0165	0.0165
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0244	0.0396
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0244	0.0253
Schistosoma mansoni	zinc finger protein	0.0036	0.0165	0.0165
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.0165	0.0171
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0154	0.0154
Loa Loa (eye worm)	hypothetical protein	0.004	0.0206	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0268
Brugia malayi	hypothetical protein	0.004	0.0206	0.0335
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0077	0.0549	0.0571
Onchocerca volvulus	Bile acid receptor homolog	0.0077	0.0549	1
Plasmodium falciparum	flap endonuclease 1	0.0025	0.0062	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0077	0.0549	0.0892
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.004	0.0206	0.0206
Schistosoma mansoni	nuclear hormone receptor	0.0077	0.0549	0.0549
Schistosoma mansoni	nuclear hormone receptor	0.0036	0.0165	0.0165
Schistosoma mansoni	thyroid hormone receptor	0.0077	0.0549	0.0549
Schistosoma mansoni	nuclear receptor	0.0036	0.0165	0.0165
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0244	0.0244
Schistosoma mansoni	DNA polymerase eta	0.0044	0.0235	0.0235
Echinococcus granulosus	geminin	0.0165	0.1384	0.1384
Entamoeba histolytica	hypothetical protein	0.0035	0.0154	0.025
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0054	0.0088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0244	0.0244
Brugia malayi	Nuclear hormone receptor-like 1	0.004	0.0206	0.0335
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0077	0.0549	0.0571
Brugia malayi	ImpB/MucB/SamB family protein	0.0044	0.0235	0.0382
Schistosoma mansoni	nuclear hormone receptor	0.0036	0.0165	0.0165
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0244	0.0396
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0036	0.0165	0.0171
Echinococcus multilocularis	flap endonuclease 1	0.0025	0.0062	0.0065
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.004	0.0206	0.0335
Schistosoma mansoni	retinoic acid receptor RXR	0.1073	1	1
Leishmania major	DNA polymerase eta, putative	0.0044	0.0235	0.0382
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0077	0.0549	0.0549
Schistosoma mansoni	hypothetical protein	0.0165	0.1384	0.1384
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0077	0.0549	0.0892
Echinococcus multilocularis	geminin	0.0165	0.1384	0.1439
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0667	0.6153	1
Loa Loa (eye worm)	flap endonuclease-1	0.0025	0.0062	0.0101
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1033	0.9616	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0549	0.0892
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0	0.5
Brugia malayi	nuclear receptor RXR	0.0036	0.0165	0.0268
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0077	0.0549	0.0892
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0077	0.0549	0.0571
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0025	0.0062	0.1335
Brugia malayi	nuclear receptor NHR-88	0.0036	0.0165	0.0268
Brugia malayi	ecdysone receptor	0.0036	0.0165	0.0268
Plasmodium vivax	flap endonuclease 1, putative	0.0025	0.0062	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0036	0.0165	0.0268
Onchocerca volvulus	Protein ultraspiracle homolog	0.0077	0.0549	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0077	0.0549	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0268
Brugia malayi	orphan nuclear receptor NR2E1	0.0036	0.0165	0.0268
Schistosoma mansoni	serine/threonine protein kinase	0.0231	0.201	0.201
Brugia malayi	nuclear receptor NHR-67	0.0036	0.0165	0.0268
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0406	0.0406
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0231	0.201	0.3267
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0036	0.0165	0.0268
Brugia malayi	Flap endonuclease-1	0.0025	0.0062	0.0101
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0077	0.0549	0.0892
Brugia malayi	RNA binding protein	0.0062	0.0406	0.066
Brugia malayi	Nuclear hormone receptor E75	0.0036	0.0165	0.0268
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0077	0.0549	0.0549
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0077	0.0549	0.0549
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0036	0.0165	0.0171
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0054	0.0088
Echinococcus multilocularis	FTZ F1 alpha	0.0077	0.0549	0.0571
Entamoeba histolytica	Flap nuclease, putative	0.0025	0.0062	0.0101
Echinococcus granulosus	flap endonuclease 1	0.0025	0.0062	0.0062
Trypanosoma brucei	DNA polymerase eta, putative	0.0044	0.0235	0.0382
Echinococcus multilocularis	ecdysone induced protein 78C	0.0077	0.0549	0.0571
Echinococcus granulosus	dna polymerase eta	0.0044	0.0235	0.0235
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0077	0.0549	0.0549
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0077	0.0549	0.0892
Echinococcus multilocularis	dna polymerase eta	0.0044	0.0235	0.0244
Brugia malayi	nuclear hormone receptor family member odr-7	0.0036	0.0165	0.0268
Echinococcus multilocularis	transcription factor Dp 1	0.0386	0.3487	0.3626
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0025	0.0062	0.0101
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.004	0.0206	0.0214
Brugia malayi	steroid hormone receptor	0.0077	0.0549	0.0892
Giardia lamblia	Flap structure-specific endonuclease	0.0025	0.0062	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0077	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0549	0.0892
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0077	0.0549	0.0892
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0667	0.6153	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0549	0.0892
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0077	0.0549	0.0892
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0406	0.066
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0077	0.0549	0.0892
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0077	0.0549	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0549	0.0892
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0077	0.0549	0.0892
Brugia malayi	TAR-binding protein	0.0062	0.0406	0.066
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0077	0.0549	0.0892
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0667	0.6153	0.6153
Brugia malayi	hypothetical protein	0.0024	0.0054	0.0088
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0667	0.6153	0.6399
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0077	0.0549	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0268
Loa Loa (eye worm)	hypothetical protein	0.004	0.0206	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0268
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0077	0.0549	0.0549
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0406	0.0406
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0667	0.6153	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0077	0.0549	0.0571
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0025	0.0062	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0268
Loa Loa (eye worm)	DR-78	0.0036	0.0165	0.0268
Brugia malayi	hypothetical protein	0.0035	0.0154	0.025
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0054	0.0088
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0406	0.066
Loa Loa (eye worm)	hypothetical protein	0.004	0.0206	0.0335
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0036	0.0165	0.0165
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0077	0.0549	0.0892
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0406	0.0406
Schistosoma mansoni	flap endonuclease-1	0.0023	0.0039	0.0039
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0036	0.0165	0.0268
Echinococcus multilocularis	nuclear receptor nhr 48	0.0036	0.0165	0.0171
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0036	0.0165	0.0268
Trypanosoma cruzi	DNA polymerase eta, putative	0.0044	0.0235	0.0382
Brugia malayi	Steroid receptor seven-up type 2	0.0077	0.0549	0.0892
Brugia malayi	hypothetical protein	0.0036	0.0165	0.0268
Loa Loa (eye worm)	steroid hormone receptor	0.0077	0.0549	0.0892
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0077	0.0549	0.0892
Loa Loa (eye worm)	hypothetical protein	0.004	0.0206	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0268
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0077	0.0549	0.0549
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0077	0.0549	0.0549
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0406	0.0422
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0406	0.066
Brugia malayi	nuclear receptor NHR-88	0.0077	0.0549	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0268
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0077	0.0549	0.0892
Schistosoma mansoni	nuclear receptor	0.0036	0.0165	0.0165
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0031	0.0112	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0077	0.0549	0.0571

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (ADMET)	> 100 ug ml-1	Cytotoxicity against human A549 cells	ChEMBL.	22200403

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1935637

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1595336