Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0586 | 0.0689 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0586 | 0.0689 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0504 | 0.0591 | 0.1651 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0504 | 0.0591 | 0.1651 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0586 | 0.0689 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.2985 | 0.3576 | 1 |
Brugia malayi | hypothetical protein | 0.0504 | 0.0591 | 0.1636 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.0591 | 0.1648 |
Brugia malayi | Carboxylesterase family protein | 0.0504 | 0.0591 | 0.1636 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0586 | 0.0689 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0008 | 0.0019 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0586 | 0.0689 | 0.1927 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0504 | 0.0591 | 0.1651 |
Echinococcus granulosus | carboxylesterase 5A | 0.2985 | 0.3576 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0586 | 0.0689 | 0.1923 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0019 | 0.0007 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0586 | 0.0689 | 0.1923 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.0591 | 0.1648 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0504 | 0.0591 | 0.1651 |
Loa Loa (eye worm) | hypothetical protein | 0.0586 | 0.0689 | 0.1923 |
Echinococcus granulosus | neuroligin | 0.0504 | 0.0591 | 0.1651 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0504 | 0.0591 | 0.1651 |
Schistosoma mansoni | amine oxidase | 0.0586 | 0.0689 | 0.1927 |
Echinococcus granulosus | acetylcholinesterase | 0.2985 | 0.3576 | 1 |
Echinococcus multilocularis | neuroligin | 0.0504 | 0.0591 | 0.1651 |
Schistosoma mansoni | gliotactin | 0.0504 | 0.0591 | 0.1651 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.0591 | 0.1648 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0504 | 0.0591 | 0.1651 |
Loa Loa (eye worm) | hypothetical protein | 0.2985 | 0.3576 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0586 | 0.0689 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0008 | 0.0019 |
Mycobacterium ulcerans | oxidoreductase | 0.0586 | 0.0689 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.2985 | 0.3576 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.0591 | 0.1648 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0586 | 0.0689 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0504 | 0.0591 | 0.1648 |
Schistosoma mansoni | amine oxidase | 0.0586 | 0.0689 | 0.1927 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0504 | 0.0591 | 0.1651 |
Plasmodium vivax | hypothetical protein, conserved | 0.0586 | 0.0689 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0586 | 0.0689 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.002 | 0.0008 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0586 | 0.0689 | 0.1923 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2985 | 0.3576 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0586 | 0.0689 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0504 | 0.0591 | 0.1651 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0001 | 0.0004 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0586 | 0.0689 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.0591 | 0.1648 |
Loa Loa (eye worm) | carboxylesterase | 0.0504 | 0.0591 | 0.1648 |
Echinococcus multilocularis | roundabout 2 | 0.0024 | 0.0013 | 0.0035 |
Brugia malayi | Carboxylesterase family protein | 0.2985 | 0.3576 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0586 | 0.0689 | 0.1911 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0504 | 0.0591 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0586 | 0.0689 | 0.1911 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0586 | 0.0689 | 0.1927 |
Brugia malayi | hypothetical protein | 0.002 | 0.0008 | 0.0004 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0586 | 0.0689 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0586 | 0.0689 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0504 | 0.0591 | 0.1651 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0504 | 0.0591 | 0.1651 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0267 | 0.0305 | 0.0852 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0586 | 0.0689 | 0.1927 |
Schistosoma mansoni | tyrosine kinase | 0.0267 | 0.0305 | 0.0852 |
Brugia malayi | hypothetical protein | 0.0586 | 0.0689 | 0.1911 |
Brugia malayi | Carboxylesterase family protein | 0.2985 | 0.3576 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2985 | 0.3576 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0024 | 0.0013 | 0.0035 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0267 | 0.0305 | 0.0852 |
Echinococcus multilocularis | acetylcholinesterase | 0.2985 | 0.3576 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0504 | 0.0591 | 0.5 |
Schistosoma mansoni | nephrin | 0.002 | 0.0008 | 0.0023 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.8324 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2985 | 0.3576 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0008 | 0.0019 |
Brugia malayi | Fibronectin type III domain containing protein | 0.002 | 0.0008 | 0.0004 |
Brugia malayi | Carboxylesterase family protein | 0.0504 | 0.0591 | 0.1636 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0586 | 0.0689 | 0.1927 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0586 | 0.0689 | 0.1927 |
Schistosoma mansoni | acetylcholinesterase | 0.0504 | 0.0591 | 0.1651 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0586 | 0.0689 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0586 | 0.0689 | 0.1923 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2985 | 0.3576 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0586 | 0.0689 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0261 | 0.0297 | 0.0832 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.7738 | 0.9295 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0504 | 0.0591 | 0.1636 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.0591 | 0.1648 |
Echinococcus multilocularis | 0.0586 | 0.0689 | 0.1927 | |
Echinococcus granulosus | roundabout 2 | 0.0024 | 0.0013 | 0.0035 |
Mycobacterium ulcerans | monoamine oxidase | 0.0586 | 0.0689 | 0.0105 |
Onchocerca volvulus | 0.0586 | 0.0689 | 1 | |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0586 | 0.0689 | 0.0113 |
Mycobacterium ulcerans | dehydrogenase | 0.0586 | 0.0689 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0586 | 0.0689 | 0.1923 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0586 | 0.0689 | 0.0113 |
Echinococcus multilocularis | acetylcholinesterase | 0.2985 | 0.3576 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0586 | 0.0689 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.0591 | 0.1648 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0504 | 0.0591 | 0.1651 |
Brugia malayi | Carboxylesterase family protein | 0.0504 | 0.0591 | 0.1636 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0586 | 0.0689 | 0.1927 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.