Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0088 | 0.0163 | 0.0163 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0588 | 0.5869 | 0.5869 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0215 | 0.1616 | 0.1616 |
Loa Loa (eye worm) | thymidylate synthase | 0.0215 | 0.1616 | 0.1477 |
Echinococcus granulosus | adenosylhomocysteinase | 0.095 | 1 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.095 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0088 | 0.0163 | 0.0163 |
Brugia malayi | thymidylate synthase | 0.0215 | 0.1616 | 0.1477 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.095 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.095 | 1 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.095 | 1 | 0.5 |
Onchocerca volvulus | 0.0215 | 0.1616 | 0.5 | |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.095 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.095 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.095 | 1 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0564 | 0.5598 | 0.5598 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.095 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0298 | 0.2565 | 0.2311 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.095 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0102 | 0.033 | 0.0169 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.095 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0215 | 0.1616 | 0.1616 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0215 | 0.1616 | 0.1616 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.2422 | 0.2296 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.095 | 1 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.382 | 0.382 |
Schistosoma mansoni | adenosylhomocysteinase | 0.095 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0088 | 0.0163 | 0.0163 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.095 | 1 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.0564 | 0.5598 | 0.5598 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0303 | 0.2616 | 0.2364 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.095 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0588 | 0.5869 | 0.5869 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0088 | 0.0163 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0588 | 0.5869 | 0.5869 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.2422 | 0.2422 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0102 | 0.033 | 0.033 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0588 | 0.5869 | 0.5869 |
Mycobacterium ulcerans | thymidylate synthase | 0.0215 | 0.1616 | 0.1616 |
Echinococcus multilocularis | thymidylate synthase | 0.0215 | 0.1616 | 0.1616 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.2422 | 0.2422 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.382 | 0.382 |
Plasmodium falciparum | adenosylhomocysteinase | 0.095 | 1 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.095 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0303 | 0.2616 | 0.2616 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0303 | 0.2616 | 0.2616 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.095 | 1 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0564 | 0.5598 | 0.5598 |
Brugia malayi | hypothetical protein | 0.0286 | 0.2422 | 0.2296 |
Echinococcus granulosus | dihydrofolate reductase | 0.0088 | 0.0163 | 0.0163 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0215 | 0.1616 | 0.1477 |
Schistosoma mansoni | dihydrofolate reductase | 0.0088 | 0.0163 | 0.0163 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0564 | 0.5598 | 0.5598 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.