Detailed information for compound 1595685

Basic information

Technical information
  • TDR Targets ID: 1595685
  • Name: N-(2-diethylaminoethyl)-2-(3-ethyl-4-oxophtha lazin-1-yl)propanamide
  • MW: 344.451 | Formula: C19H28N4O2
  • H donors: 1 H acceptors: 2 LogP: 2.36 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNC(=O)C(c1nn(CC)c(=O)c2c1cccc2)C)CC
  • InChi: 1S/C19H28N4O2/c1-5-22(6-2)13-12-20-18(24)14(4)17-15-10-8-9-11-16(15)19(25)23(7-3)21-17/h8-11,14H,5-7,12-13H2,1-4H3,(H,20,24)
  • InChiKey: ADQLZUNQGOZRLA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-diethylaminoethyl)-2-(3-ethyl-4-oxo-phthalazin-1-yl)propanamide
  • N-(2-diethylaminoethyl)-2-(3-ethyl-4-oxo-1-phthalazinyl)propanamide
  • N-(2-diethylaminoethyl)-2-(3-ethyl-4-keto-phthalazin-1-yl)propionamide
  • BAS 02824444

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-CoA:1-acylglycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Plasmodium vivax 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Trypanosoma cruzi acyltransferase, putative 0.0006 0.5 0.5
Schistosoma mansoni acetyltransferase-related 0.0006 0.5 0.5
Mycobacterium tuberculosis Possible acyltransferase 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Plasmodium falciparum phospholipid or glycerol acyltransferase, putative 0.0006 0.5 0.5
Entamoeba histolytica 1-acyl-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Echinococcus multilocularis 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Schistosoma mansoni 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Giardia lamblia Hypothetical protein 0.0006 0.5 0.5
Mycobacterium ulcerans 1-acylglycerol-3-phosphate O-acyltransferase 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Schistosoma mansoni acetyltransferase-related 0.0006 0.5 0.5
Treponema pallidum lysophosphatidic acid acyltransferase 0.0006 0.5 0.5
Echinococcus multilocularis 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Mycobacterium tuberculosis 1-acylglycerol-3-phosphate O-acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) ACL-8 protein 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Plasmodium falciparum glycerol-3-phosphate 1-O-acyltransferase 0.0006 0.5 0.5
Mycobacterium ulcerans glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Mycobacterium leprae POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI 0.0006 0.5 0.5
Mycobacterium ulcerans bifunctional transmembrane phospholipid biosynthesis enzyme PlsC 0.0006 0.5 0.5
Trichomonas vaginalis 1-acyl-sn-glycerol-3-phosphate acyltransferase eta, putative 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Trypanosoma brucei acetyltransferase, putative 0.0006 0.5 0.5
Trypanosoma brucei dihydroxyacetone phosphate acyltransferase, putative 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Echinococcus granulosus Phospholipid glycerol acyltransferase 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Trypanosoma brucei glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Trypanosoma cruzi dihydroxyacetone phosphate acyltransferase, putative 0.0006 0.5 0.5
Mycobacterium ulcerans acyltransferase 0.0006 0.5 0.5
Echinococcus multilocularis tafazzin 0.0006 0.5 0.5
Plasmodium falciparum 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) ACL-5 protein 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Mycobacterium tuberculosis Probable membrane protein 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Echinococcus granulosus 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0006 0.5 0.5
Echinococcus granulosus tafazzin 0.0006 0.5 0.5
Leishmania major glycerol-3-phosphate acyl transferase 0.0006 0.5 0.5
Trypanosoma brucei acyltransferase, putative 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Mycobacterium leprae Probable 1-acylglycerol-3-phosphate O-acyltransferase 0.0006 0.5 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0006 0.5 0.5
Plasmodium falciparum glycerol-3-phosphate 1-O-acyltransferase 0.0006 0.5 0.5
Schistosoma mansoni 1-acyl-sn-glycerol-3-phosphate o-acyltransferase 0.0006 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.5 0.5
Toxoplasma gondii glycerol-3-phosphate-acyltransferase 0.0006 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.5 0.5
Echinococcus granulosus 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Trypanosoma cruzi glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Giardia lamblia Hypothetical protein 0.0006 0.5 0.5
Schistosoma mansoni acyl-CoA:glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Giardia lamblia Hypothetical protein 0.0006 0.5 0.5
Brugia malayi Acyltransferase-like protein 4 0.0006 0.5 0.5
Leishmania major dihydroxyacetonephosphate acyltransferase 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Chlamydia trachomatis sn=glycerol 3-phosphate acyltransferase 0.0006 0.5 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0006 0.5 0.5
Echinococcus multilocularis acetyltransferase 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Wolbachia endosymbiont of Brugia malayi 1-acyl-sn-glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Plasmodium vivax phospholipid or glycerol acyltransferase, putative 0.0006 0.5 0.5
Treponema pallidum hypothetical protein 0.0006 0.5 0.5
Trypanosoma cruzi dihydroxyacetone phosphate acyltransferase, putative 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Leishmania major hypothetical protein, unknown function 0.0006 0.5 0.5
Mycobacterium tuberculosis Possible acyltransferase 0.0006 0.5 0.5
Echinococcus multilocularis Phospholipid glycerol acyltransferase 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Trypanosoma brucei 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Mycobacterium leprae Possible acyltransferase 0.0006 0.5 0.5
Schistosoma mansoni 1-acylglycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Trypanosoma brucei acyltransferase, putative 0.0006 0.5 0.5
Schistosoma mansoni taz protein (tafazzin) 0.0006 0.5 0.5
Mycobacterium tuberculosis Conserved protein 0.0006 0.5 0.5
Chlamydia trachomatis glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Mycobacterium ulcerans acyltransferase 0.0006 0.5 0.5
Echinococcus granulosus lysocardiolipin acyltransferase 1 0.0006 0.5 0.5
Giardia lamblia Lysophosphatidic acid acyltransferase, putative 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Trypanosoma cruzi acyltransferase, putative 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Echinococcus multilocularis 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Onchocerca volvulus Transmembrane protein 68 homolog 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Leishmania major acyltransferase-like protein, copy 1 0.0006 0.5 0.5
Trypanosoma cruzi 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Echinococcus granulosus acetyltransferase 0.0006 0.5 0.5
Trichomonas vaginalis 1-acylglycerophosphocholine O-acyltransferase, putative 0.0006 0.5 0.5
Plasmodium vivax glycerol-3-phosphate 1-O-acyltransferase, putative 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Mycobacterium tuberculosis Possible acyltransferase 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Mycobacterium tuberculosis Possible acyltransferase PlsB1 0.0006 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Echinococcus multilocularis glycerol 3 phosphate acyltransferase 3 0.0006 0.5 0.5
Trypanosoma cruzi glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Echinococcus granulosus 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Onchocerca volvulus 0.0006 0.5 0.5
Mycobacterium ulcerans acyltransferase 0.0006 0.5 0.5
Leishmania major acyltransferase-like protein, copy 2 0.0006 0.5 0.5
Echinococcus multilocularis lysocardiolipin acyltransferase 1 0.0006 0.5 0.5
Mycobacterium leprae conserved hypothetical protein 0.0006 0.5 0.5
Giardia lamblia Hypothetical protein 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Leishmania major 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative 0.0006 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.5 0.5
Trichomonas vaginalis 1-acyl-sn-glycerol-3-phosphate acyltransferase eta, putative 0.0006 0.5 0.5
Chlamydia trachomatis glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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