Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.1001 | 0.1001 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 1 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.4263 | 0.4263 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.4263 | 0.4263 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.4263 | 0.4263 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.4263 | 0.4263 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.4263 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.4263 | 0.4263 |
Leishmania major | cytochrome p450-like protein | 0.0019 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.1001 | 0.1001 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.2556 | 0.2556 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.2556 | 0.2556 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4263 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4263 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.4263 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4263 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4263 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4263 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.4263 | 0.4263 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.85 nM | Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay | ChEMBL. | 22284268 |
IC50 (functional) | = 5.44 nM | Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by MTT assay | ChEMBL. | 22284268 |
IC50 (functional) | = 9.85 nM | Cytotoxicity against human KB cells assessed as cell viability after 72 hrs by MTT assay | ChEMBL. | 22284268 |
IC50 (functional) | = 11.43 nM | Cytotoxicity against human Bel7402 cells assessed as cell viability after 72 hrs by MTT assay | ChEMBL. | 22284268 |
IC50 (functional) | = 15.47 nM | Cytotoxicity against human Ketr3 cells assessed as cell viability after 72 hrs by MTT assay | ChEMBL. | 22284268 |
IC50 (functional) | = 27.36 nM | Cytotoxicity against human HCT8 cells assessed as cell viability after 72 hrs by MTT assay | ChEMBL. | 22284268 |
IC50 (functional) | = 33.74 nM | Cytotoxicity against human A2780 cells assessed as cell viability after 72 hrs by MTT assay | ChEMBL. | 22284268 |
IC50 (functional) | = 81.82 nM | Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay | ChEMBL. | 22284268 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22284268 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.