Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | G protein coupled receptor kinase 1 | 0.1009 | 0.1242 | 0.2861 |
Entamoeba histolytica | cyclin, putative | 0.1134 | 0.152 | 1 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.1096 | 0.1434 | 1 |
Brugia malayi | diacylglycerol acyltransferase family protein | 0.2739 | 0.5095 | 0.483 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.2739 | 0.5095 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.1134 | 0.152 | 1 |
Brugia malayi | cell division control protein 2 homolog | 0.0885 | 0.0963 | 0.0475 |
Loa Loa (eye worm) | hypothetical protein | 0.1826 | 0.306 | 0.306 |
Loa Loa (eye worm) | carboxylesterase | 0.1826 | 0.306 | 0.306 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0885 | 0.0963 | 0.5173 |
Trichomonas vaginalis | cyclin B3, putative | 0.0682 | 0.0513 | 0.1265 |
Entamoeba histolytica | protein kinase, putative | 0.1096 | 0.1434 | 0.9148 |
Trichomonas vaginalis | cyclin D, putative | 0.0682 | 0.0513 | 0.1265 |
Echinococcus granulosus | acetylcholinesterase | 0.1826 | 0.306 | 1 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.1124 | 0.1496 | 0.3862 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.1134 | 0.152 | 0.2475 |
Entamoeba histolytica | protein kinase, putative | 0.1096 | 0.1434 | 0.9148 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0682 | 0.0513 | 0.0513 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.1124 | 0.1496 | 0.1496 |
Trypanosoma cruzi | cyclin, putative | 0.1134 | 0.152 | 0.2475 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.2739 | 0.5095 | 1 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.1124 | 0.1496 | 0.3862 |
Brugia malayi | Carboxylesterase family protein | 0.1826 | 0.306 | 0.2685 |
Trichomonas vaginalis | AGC family protein kinase | 0.1096 | 0.1434 | 0.9256 |
Mycobacterium ulcerans | hypothetical protein | 0.0607 | 0.0345 | 0.5 |
Trypanosoma cruzi | cyclin, putative | 0.1134 | 0.152 | 0.2475 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0885 | 0.0963 | 0.1303 |
Echinococcus multilocularis | cyclin B | 0.1134 | 0.152 | 0.3955 |
Echinococcus granulosus | cyclin B | 0.1134 | 0.152 | 0.3955 |
Loa Loa (eye worm) | AUR protein kinase | 0.1096 | 0.1434 | 0.1434 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1096 | 0.1434 | 0.2294 |
Schistosoma mansoni | cyclin B | 0.1134 | 0.152 | 0.2475 |
Echinococcus multilocularis | G protein coupled receptor kinase 1 | 0.1009 | 0.1242 | 0.2861 |
Trypanosoma cruzi | aurora B kinase, putative | 0.1096 | 0.1434 | 0.2294 |
Trichomonas vaginalis | cyclin B, putative | 0.1134 | 0.152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1826 | 0.306 | 0.306 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.1096 | 0.1434 | 0.9148 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0885 | 0.0963 | 0.4474 |
Echinococcus multilocularis | aurora kinase A | 0.1096 | 0.1434 | 0.3618 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1826 | 0.306 | 0.306 |
Trichomonas vaginalis | AGC family protein kinase | 0.1096 | 0.1434 | 0.9256 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0885 | 0.0963 | 0.1303 |
Brugia malayi | serine/threonine protein kinase 6 | 0.1096 | 0.1434 | 0.0971 |
Trypanosoma brucei | aurora B kinase | 0.1096 | 0.1434 | 0.2294 |
Entamoeba histolytica | protein kinase , putative | 0.1096 | 0.1434 | 0.9148 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0885 | 0.0963 | 0.0963 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.2739 | 0.5095 | 1 |
Onchocerca volvulus | 0.2739 | 0.5095 | 1 | |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.2739 | 0.5095 | 1 |
Toxoplasma gondii | dgat2l1-prov protein | 0.2739 | 0.5095 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0682 | 0.0513 | 0.1265 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0885 | 0.0963 | 0.1769 |
Echinococcus granulosus | acetylcholinesterase | 0.1826 | 0.306 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0885 | 0.0963 | 0.1303 |
Giardia lamblia | Kinase, CMGC CDK | 0.0885 | 0.0963 | 0.4474 |
Schistosoma mansoni | protein kinase | 0.1096 | 0.1434 | 0.2294 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0885 | 0.0963 | 0.5173 |
Toxoplasma gondii | aurora kinase | 0.1096 | 0.1434 | 0.2603 |
Trichomonas vaginalis | cyclin A, putative | 0.1134 | 0.152 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.1134 | 0.152 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1096 | 0.1434 | 0.9148 |
Schistosoma mansoni | cyclins | 0.0682 | 0.0513 | 0.0354 |
Schistosoma mansoni | cyclin B3 | 0.0682 | 0.0513 | 0.0354 |
Leishmania major | cyclin | 0.1134 | 0.152 | 0.2475 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1826 | 0.306 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.1096 | 0.1434 | 0.1434 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0885 | 0.0963 | 0.1303 |
Echinococcus multilocularis | acetylcholinesterase | 0.1826 | 0.306 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.1134 | 0.152 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0885 | 0.0963 | 0.1303 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.1134 | 0.152 | 0.2475 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0885 | 0.0963 | 0.1769 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.1134 | 0.152 | 1 |
Echinococcus granulosus | aurora kinase A | 0.1096 | 0.1434 | 0.3618 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.1096 | 0.1434 | 0.0971 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0885 | 0.0963 | 0.1769 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.2739 | 0.5095 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.1134 | 0.152 | 0.1062 |
Trichomonas vaginalis | AGC family protein kinase | 0.1096 | 0.1434 | 0.9256 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0885 | 0.0963 | 0.1769 |
Trichomonas vaginalis | cyclins, putative | 0.0682 | 0.0513 | 0.1265 |
Echinococcus granulosus | cyclin dependent kinase | 0.0885 | 0.0963 | 0.1769 |
Trichomonas vaginalis | AGC family protein kinase | 0.1096 | 0.1434 | 0.9256 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.1096 | 0.1434 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1826 | 0.306 | 0.5716 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0682 | 0.0513 | 0.1265 |
Trichomonas vaginalis | cyclins, putative | 0.1134 | 0.152 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.1134 | 0.152 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1124 | 0.1496 | 0.2425 |
Loa Loa (eye worm) | hypothetical protein | 0.0864 | 0.0917 | 0.0917 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0885 | 0.0963 | 0.5173 |
Giardia lamblia | Aurora kinase | 0.1096 | 0.1434 | 0.9148 |
Echinococcus granulosus | carboxylesterase 5A | 0.1826 | 0.306 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0682 | 0.0513 | 0.1265 |
Trichomonas vaginalis | cyclins, putative | 0.1134 | 0.152 | 1 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0885 | 0.0963 | 0.1303 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.1096 | 0.1434 | 0.3618 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1124 | 0.1496 | 0.2425 |
Loa Loa (eye worm) | hypothetical protein | 0.1134 | 0.152 | 0.152 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.1134 | 0.152 | 0.1062 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.1096 | 0.1434 | 0.9148 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0885 | 0.0963 | 0.0963 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0885 | 0.0963 | 0.1769 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0885 | 0.0963 | 0.1769 |
Trichomonas vaginalis | cyclin B, putative | 0.1134 | 0.152 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0885 | 0.0963 | 0.1303 |
Brugia malayi | Protein kinase domain containing protein | 0.0885 | 0.0963 | 0.0475 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.1096 | 0.1434 | 0.9148 |
Toxoplasma gondii | diacylglycerol acyltransferase | 0.0607 | 0.0345 | 0.0401 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.2739 | 0.5095 | 0.5095 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0885 | 0.0963 | 0.0963 |
Trypanosoma brucei | mitotic cyclin 6 | 0.1134 | 0.152 | 0.2475 |
Giardia lamblia | Kinase, CMGC CDK | 0.0885 | 0.0963 | 0.4474 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0885 | 0.0963 | 0.1769 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0885 | 0.0963 | 0.1303 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0885 | 0.0963 | 0.4474 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0885 | 0.0963 | 0.1303 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0885 | 0.0963 | 0.1303 |
Plasmodium falciparum | protein kinase 5 | 0.0885 | 0.0963 | 0.4891 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0885 | 0.0963 | 0.1652 |
Trypanosoma cruzi | cyclin 6, putative | 0.1134 | 0.152 | 0.2475 |
Loa Loa (eye worm) | hypothetical protein | 0.1134 | 0.152 | 0.152 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.1096 | 0.1434 | 0.3618 |
Toxoplasma gondii | mono- or diacylglycerol acyltransferase | 0.0607 | 0.0345 | 0.0401 |
Leishmania major | protein kinase, putative | 0.1096 | 0.1434 | 0.2294 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.4941 | 1 | 1 |
Brugia malayi | serine/threonine kinase 12 | 0.1096 | 0.1434 | 0.0971 |
Brugia malayi | Carboxylesterase family protein | 0.1826 | 0.306 | 0.2685 |
Loa Loa (eye worm) | AUR protein kinase | 0.1096 | 0.1434 | 0.1434 |
Echinococcus multilocularis | acetylcholinesterase | 0.1826 | 0.306 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 24.36 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 45 days | ChEMBL. | 22154833 |
Ratio (functional) | = 2 | Ratio of ethambutol dihydrochloride MIC to compound MIC for Mycobacterium tuberculosis H37Rv | ChEMBL. | 22154833 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.