Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 19, subfamily A, polypeptide 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | cytochrome P450, family 19, subfamily A, polypeptide 1 | 503 aa | 425 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.3069 | 0.3519 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.7721 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.3069 | 0.3519 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3069 | 0.3519 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.3069 | 0.3519 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3069 | 0.3519 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.3069 | 0.3519 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0544 | 0 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0544 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.7177 | 0.9242 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0544 | 0 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0544 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0544 | 0 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0544 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3069 | 0.3519 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0544 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0544 | 0 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0544 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0544 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3069 | 0.3519 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.3069 | 0.3519 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0544 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.3069 | 0.3519 | 1 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0544 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3069 | 0.3519 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3069 | 0.3519 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0544 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0544 | 0 | 0.5 |
Onchocerca volvulus | 0.0544 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.3069 | 0.3519 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (ADMET) | Inhibition of CYP3A4 at 10 uM | ChEMBL. | 22079757 | |
Ki (ADMET) | = 4.51 | Inhibition of CYP1A1 | ChEMBL. | 22079757 |
Ki (binding) | = 7 | Inhibition of human recombinant aromatase assessed as conversion of O-dibenzylfluorescein benzyl ester substrate to fluorescein byproduct by fluorometric assay | ChEMBL. | 22079757 |
Ki (binding) | = 0.1 uM | Inhibition of human recombinant aromatase assessed as conversion of O-dibenzylfluorescein benzyl ester substrate to fluorescein byproduct by fluorometric assay | ChEMBL. | 22079757 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.