Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.2967 | 0.2329 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.331 | 0.2702 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0832 | 0.2514 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.2967 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.331 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0832 | 0.2514 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.2967 | 0.2329 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0037 | 0.1511 | 0.0741 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.2967 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0832 | 0.2514 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.325 | 0.2637 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.331 | 0.2702 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.2967 | 0.2329 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0064 | 0.331 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.325 | 0.2637 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.325 | 0.2637 |
Brugia malayi | RNA binding protein | 0.0063 | 0.325 | 0.982 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.2967 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.325 | 0.982 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.325 | 0.982 |
Onchocerca volvulus | 0.0027 | 0.0832 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.325 | 0.2637 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.325 | 0.982 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0037 | 0.1511 | 0.0741 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.331 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0064 | 0.331 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0832 | 0.2514 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.325 | 0.982 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.331 | 0.2702 |
Onchocerca volvulus | 0.0027 | 0.0832 | 0.5 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.2967 | 0.2329 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.325 | 0.2637 |
Echinococcus multilocularis | geminin | 0.0164 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.2967 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.325 | 0.2637 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0064 | 0.331 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.325 | 0.2637 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.331 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0799 | 0.2415 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.2967 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.325 | 0.982 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0832 | 0.2514 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.331 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.27 uM | Antimelanogenic activity at alpha-MSH-stimulated mouse melanoma B16 cells after 3 days by spectrophotometry | ChEMBL. | 22217872 |
Inhibition (functional) | > 100 % | Antimelanogenic activity at alpha-MSH-stimulated mouse melanoma B16 cells at 10 uM after 3 days by spectrophotometry | ChEMBL. | 22217872 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 22217872 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.