Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0464 | 0.8576 | 0.8957 |
Leishmania major | histone deacetylase, putative | 0.0464 | 0.8576 | 0.8957 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.399 | 0.3977 |
Echinococcus granulosus | histone deacetylase 8 | 0.023 | 0.2921 | 0.2682 |
Toxoplasma gondii | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0313 | 0.4938 | 0.5007 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0464 | 0.8576 | 0.8957 |
Brugia malayi | Histone deacetylase family protein | 0.0504 | 0.9536 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0504 | 0.9536 | 0.9521 |
Schistosoma mansoni | histone deacetylase | 0.0464 | 0.8576 | 0.8528 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0523 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0504 | 0.9536 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0504 | 0.9536 | 0.9521 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0504 | 0.9536 | 0.9521 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0313 | 0.4938 | 0.5758 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0504 | 0.9536 | 1 |
Leishmania major | histone deacetylase, putative | 0.0464 | 0.8576 | 0.8957 |
Leishmania major | histone deacetylase, putative | 0.0504 | 0.9536 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0504 | 0.9536 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0313 | 0.4938 | 0.5758 |
Echinococcus granulosus | histone deacetylase 3 | 0.0464 | 0.8576 | 0.8528 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.023 | 0.2921 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0504 | 0.9536 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0504 | 0.9536 | 0.9521 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1648 | 0.1435 |
Entamoeba histolytica | hypothetical protein | 0.0205 | 0.2312 | 0.2696 |
Entamoeba histolytica | histone deacetylase, putative | 0.0464 | 0.8576 | 1 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.023 | 0.2921 | 0.2817 |
Brugia malayi | dUTP diphosphatase | 0.0313 | 0.4938 | 0.5007 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0504 | 0.9536 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0464 | 0.8576 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0407 | 0.7195 | 0.7458 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0313 | 0.4938 | 0.5758 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0313 | 0.4938 | 0.5758 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0464 | 0.8576 | 0.8957 |
Schistosoma mansoni | histone deacetylase | 0.0464 | 0.8576 | 0.8528 |
Echinococcus multilocularis | histone deacetylase | 0.0504 | 0.9536 | 0.9521 |
Loa Loa (eye worm) | histone deacetylase | 0.0504 | 0.9536 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0313 | 0.4938 | 0.5758 |
Trypanosoma brucei | histone deacetylase, putative | 0.0504 | 0.9536 | 1 |
Leishmania major | histone deacetylase, putative | 0.0504 | 0.9536 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0464 | 0.8576 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0464 | 0.8576 | 0.8528 |
Plasmodium vivax | histone deacetylase, putative | 0.0504 | 0.9536 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0464 | 0.8576 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0313 | 0.4938 | 0.5758 |
Wolbachia endosymbiont of Brugia malayi | dUTPase | 0.0313 | 0.4938 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0504 | 0.9536 | 0.9521 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0504 | 0.9536 | 1 |
Chlamydia trachomatis | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0313 | 0.4938 | 1 |
Loa Loa (eye worm) | dUTP diphosphatase | 0.0313 | 0.4938 | 0.5007 |
Trypanosoma cruzi | histone deacetylase, putative | 0.023 | 0.2921 | 0.2817 |
Brugia malayi | Histone deacetylase 1 | 0.0464 | 0.8576 | 0.8957 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0464 | 0.8576 | 0.8957 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0464 | 0.8576 | 0.8957 |
Trypanosoma brucei | histone deacetylase 3 | 0.0504 | 0.9536 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0504 | 0.9536 | 0.9521 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0464 | 0.8576 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0504 | 0.9536 | 0.9521 |
Plasmodium vivax | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0313 | 0.4938 | 0.5007 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0464 | 0.8576 | 0.8528 |
Schistosoma mansoni | histone deacetylase hda2 | 0.023 | 0.2921 | 0.2682 |
Echinococcus granulosus | histone deacetylase | 0.0504 | 0.9536 | 0.9521 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0464 | 0.8576 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0504 | 0.9536 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0464 | 0.8576 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.0504 | 0.9536 | 1 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0407 | 0.7195 | 0.7458 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0122 | 0.0327 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.023 | 0.2921 | 0.2682 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0464 | 0.8576 | 1 |
Echinococcus granulosus | dUTP pyrophosphatase | 0.0313 | 0.4938 | 0.4767 |
Echinococcus multilocularis | dUTP pyrophosphatase | 0.0313 | 0.4938 | 0.4767 |
Trypanosoma brucei | histone deacetylase 2 | 0.023 | 0.2921 | 0.2817 |
Entamoeba histolytica | hypothetical protein | 0.0205 | 0.2312 | 0.2696 |
Entamoeba histolytica | hypothetical protein | 0.0313 | 0.4938 | 0.5758 |
Schistosoma mansoni | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0313 | 0.4938 | 0.4767 |
Trypanosoma brucei | histone deacetylase 1 | 0.0464 | 0.8576 | 0.8957 |
Plasmodium falciparum | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0313 | 0.4938 | 0.5007 |
Brugia malayi | histone deacetylase 11 | 0.0407 | 0.7195 | 0.7458 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0464 | 0.8576 | 0.8957 |
Giardia lamblia | Histone deacetylase | 0.0464 | 0.8576 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.023 | 0.2921 | 0.2817 |
Plasmodium falciparum | histone deacetylase, putative | 0.0504 | 0.9536 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.023 | 0.2921 | 0.2682 |
Plasmodium vivax | histone deacetylase, putative | 0.0407 | 0.7195 | 0.7458 |
Treponema pallidum | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) | 0.0313 | 0.4938 | 0.5 |
Trypanosoma brucei | histone deacetylase 4 | 0.0504 | 0.9536 | 1 |
Mycobacterium ulcerans | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0109 | 0 | 0.5 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0464 | 0.8576 | 0.8528 |
Mycobacterium leprae | PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) | 0.0109 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0464 | 0.8576 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0464 | 0.8576 | 0.8957 |
Plasmodium falciparum | histone deacetylase 1 | 0.0464 | 0.8576 | 0.8957 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0464 | 0.8576 | 0.8957 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0504 | 0.9536 | 0.9521 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.4453 | 0.448 |
Mycobacterium ulcerans | deoxycytidine triphosphate deaminase | 0.0109 | 0 | 0.5 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0523 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.8576 | 0.8957 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.2921 | 0.2817 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0313 | 0.4938 | 0.5758 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0464 | 0.8576 | 0.8957 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0464 | 0.8576 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.13 uM | Anti-HIV-1 activity tested in human lymphocytic CEM cells | ChEMBL. | 15139762 |
EC50 (functional) | = 0.18 uM | Anti-HIV-1 activity tested in human lymphocytic CEM cells | ChEMBL. | 15139762 |
EC50 (functional) | = 0.6 uM | Anti-HIV-1 activity tested in human lymphocytic CEM cells | ChEMBL. | 15139762 |
IC50 (binding) | = 2.6 uM | Inhibitory activity towards human butrylcholinesterase | ChEMBL. | 15139762 |
IC50 (binding) | = 4.2 uM | Inhibitory activity towards human butrylcholinesterase | ChEMBL. | 15139762 |
IC50 (binding) | > 50 uM | Inhibitory activity towards Electrophorus electricus acetylcholinesterase | ChEMBL. | 15139762 |
IC50 (binding) | > 50 uM | Inhibitory activity towards human butrylcholinesterase | ChEMBL. | 15139762 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.