Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | spleen tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase shark | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Echinococcus multilocularis | tyrosine protein kinase shark | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma japonicum | ko:K05855 spleen tyrosine kinase, putative | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma japonicum | ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.3807 | 0.3807 |
Schistosoma mansoni | tyrosine kinase | 0.0264 | 0.2251 | 0.2251 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1633 | 0.1633 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0194 | 0.1633 | 0.1633 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0014 | 0.0053 | 0.0053 |
Brugia malayi | Carboxylesterase family protein | 0.1147 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1147 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0009 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0014 | 0.0053 | 0.0053 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0026 | 0.0161 | 0.0161 |
Loa Loa (eye worm) | carboxylesterase | 0.0194 | 0.1633 | 0.1633 |
Echinococcus granulosus | neuroligin | 0.0194 | 0.1633 | 0.1633 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0053 | 0.0053 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | 0.0194 | 0.1633 | 1 | |
Onchocerca volvulus | 0.0194 | 0.1633 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0194 | 0.1633 | 0.1633 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0194 | 0.1633 | 0.1633 |
Echinococcus multilocularis | acetylcholinesterase | 0.1147 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1633 | 0.1633 |
Schistosoma mansoni | tyrosine kinase | 0.0258 | 0.2198 | 0.2198 |
Onchocerca volvulus | 0.0194 | 0.1633 | 1 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0194 | 0.1633 | 0.1633 |
Brugia malayi | Carboxylesterase family protein | 0.0194 | 0.1633 | 0.1633 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0161 | 0.0161 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0026 | 0.0161 | 0.0161 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0264 | 0.2251 | 0.2251 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0014 | 0.0053 | 0.0053 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0194 | 0.1633 | 0.1633 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0009 | 0.0008 | 0.0051 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0194 | 0.1633 | 0.1633 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0264 | 0.2251 | 0.2251 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0009 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | carboxylesterase | 0.1147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1633 | 0.1633 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1147 | 1 | 1 |
Onchocerca volvulus | 0.0194 | 0.1633 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0194 | 0.1633 | 0.1633 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1633 | 0.1633 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0194 | 0.1633 | 0.1633 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0008 | 0.0008 |
Brugia malayi | hypothetical protein | 0.0194 | 0.1633 | 0.1633 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1147 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0194 | 0.1633 | 0.1633 |
Brugia malayi | Carboxylesterase family protein | 0.0194 | 0.1633 | 0.1633 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0194 | 0.1633 | 0.1633 |
Echinococcus multilocularis | acetylcholinesterase | 0.1147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.3807 | 0.3807 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0194 | 0.1633 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0194 | 0.1633 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0194 | 0.1633 | 0.1633 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0009 | 0.0008 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1633 | 0.1633 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0194 | 0.1633 | 0.1633 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0194 | 0.1633 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1633 | 0.1633 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1633 | 0.1633 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0008 | 0.0008 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0194 | 0.1633 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0194 | 0.1633 | 0.1633 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0026 | 0.0161 | 0.0161 |
Brugia malayi | Carboxylesterase family protein | 0.0194 | 0.1633 | 0.1633 |
Echinococcus granulosus | acetylcholinesterase | 0.1147 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0194 | 0.1633 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0021 | 0.0117 | 0.0117 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0009 | 0.0008 | 0.0008 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0026 | 0.0161 | 0.0161 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0021 | 0.0117 | 0.0117 |
Onchocerca volvulus | 0.0194 | 0.1633 | 1 | |
Schistosoma mansoni | acetylcholinesterase | 0.0194 | 0.1633 | 0.1633 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0009 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | glutamate receptor | 0.0014 | 0.0053 | 0.0053 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0014 | 0.0053 | 0.0053 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0194 | 0.1633 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0194 | 0.1633 | 0.1633 |
Loa Loa (eye worm) | hypothetical protein | 0.1147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1147 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0194 | 0.1633 | 0.1633 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.843 uM | Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA | ChEMBL. | 22119469 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.