Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor alpha 1D | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1A | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | amine GPCR | 0.0411 | 0.1017 | 0.1017 |
Onchocerca volvulus | 0.0274 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.1623 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1623 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0274 | 0 | 0.5 |
Onchocerca volvulus | 0.0274 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.1623 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1623 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0274 | 0 | 0.5 |
Onchocerca volvulus | 0.0274 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1623 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1623 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1623 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0274 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1623 | 1 | 1 |
Onchocerca volvulus | 0.0274 | 0 | 0.5 | |
Onchocerca volvulus | 0.0274 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0274 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1623 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1623 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0274 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1623 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0274 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1623 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Emax (functional) | = 53.4 % | Agonist activity at human recombinant 5HT1A receptor expressed in HeLa cells preincubated for 20 mins by [35S]GTPgammaS binding assay relative to 8-OH-DPAT | ChEMBL. | 22145629 |
Ki (binding) | = 7.4 | Displacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting | ChEMBL. | 22145629 |
Ki (binding) | = 7.57 | Displacement of [3H]prazosin from human recombinant alpha1A adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting | ChEMBL. | 22145629 |
Ki (binding) | = 8.2 | Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting | ChEMBL. | 22145629 |
Ki (binding) | = 9.08 | Displacement of [3H]-OH-DPAT from human recombinant 5HT1A receptor expressed in HeLa cells after 30 mins by liquid scintillation counting | ChEMBL. | 22145629 |
pKb (functional) | = 6.92 | Antagonist activity at Alpha-1B receptor in Wistar rat spleen assessed as inhibition of (-)-phenylephrine-induced contraction after 30 mins | ChEMBL. | 22145629 |
pKb (functional) | = 7.24 | Antagonist activity at alpha1A adrenoceptor in Wistar rat prostatic vas deferens assessed as inhibition of (-)-noradrenalilne-induced contraction after 30 mins | ChEMBL. | 22145629 |
pKb (functional) | = 8.09 | Antagonist activity at Alpha-1D adrenoceptor in Wistar rat endothelium denuded thoracic aorta assessed as inhibition of (-)-noradrenalilne-induced contraction after 30 mins | ChEMBL. | 22145629 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.