Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0207 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0166 | 0.7589 | 0.7589 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.7589 | 0.7589 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.001 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.001 | 0.001 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.001 | 0.001 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0207 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.001 | 0.001 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.001 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0166 | 0.7589 | 0.7589 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.001 | 0.001 |
Echinococcus granulosus | carboxylesterase 5A | 0.0207 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.001 | 0.001 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.001 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0207 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0207 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0207 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0207 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.7589 | 0.7589 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.001 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0207 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0207 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.