TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 417.335 | Formula: C20H22Cl2N6
H donors: 1 H acceptors: 3 LogP: 4.83 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cc2[nH]c(nc2cc1Cl)[C@@H]1CCCN1c1ncnc(c1)N1CCCCC1
InChi: 1S/C20H22Cl2N6/c21-13-9-15-16(10-14(13)22)26-20(25-15)17-5-4-8-28(17)19-11-18(23-12-24-19)27-6-2-1-3-7-27/h9-12,17H,1-8H2,(H,25,26)/t17-/m0/s1
InChiKey: RMUXDTUSSPJZMC-KRWDZBQOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	prolylcarboxypeptidase (angiotensinase C)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K01285 lysosomal Pro-X carboxypeptidase [EC3.4.16.2], putative	Get druggable targets OG5_130246	All targets in OG5_130246
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma japonicum	IPR008758,Peptidase S28,domain-containing	Get druggable targets OG5_130246	All targets in OG5_130246
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	Get druggable targets OG5_130246	All targets in OG5_130246
Brugia malayi	Serine carboxypeptidase S28 family protein	Get druggable targets OG5_130246	All targets in OG5_130246
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma japonicum	IPR008758,Peptidase S28,domain-containing	Get druggable targets OG5_130246	All targets in OG5_130246
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130246	All targets in OG5_130246
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	Get druggable targets OG5_130246	All targets in OG5_130246

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	serine carboxypeptidase S28, putative	prolylcarboxypeptidase (angiotensinase C)	496 aa	414 aa	24.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.051	0.051
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.0827	0.0818
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0378	0.0368
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.017	0.0694
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.001	0.0034	0.5
Echinococcus multilocularis	cpg binding protein	0.003	0.0217	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0025	0.017	0.017
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0034	0.0252
Echinococcus granulosus	para nitrobenzyl esterase	0.0186	0.1645	0.1637
Onchocerca volvulus		0.001	0.0034	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1645	0.1645
Brugia malayi	hypothetical protein	0.001	0.0034	0.0034
Trichomonas vaginalis	spcc417.12 protein, putative	0.0186	0.1645	0.6873
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0025	0.017	0.016
Schistosoma mansoni	gliotactin	0.0186	0.1645	0.1637
Echinococcus granulosus	acetylcholinesterase	0.1103	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.051	0.0501
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.017	0.0694
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0034	0.0024
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0155	0.136	1
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.017	0.0694
Schistosoma mansoni	hypothetical protein	0.0399	0.3587	0.3581
Schistosoma mansoni	cpg binding protein	0.003	0.0217	0.0207
Echinococcus multilocularis	para nitrobenzyl esterase	0.0186	0.1645	0.1637
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0034	0.0124
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0186	0.1645	0.1637
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0034	0.0000018668
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0971	0.0971
Brugia malayi	DKFZp564C0469 protein	0.001	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.1103	1	1
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0155	0.136	0.1351
Brugia malayi	hypothetical protein	0.001	0.0034	0.0034
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.004	0.0313	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0186	0.1645	0.1637
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.017	0.0694
Echinococcus multilocularis	dnaJ subfamily B	0.0399	0.3587	0.3581
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.017	0.0694
Giardia lamblia	Thymus-specific serine protease precursor	0.0025	0.017	0.1026
Trypanosoma cruzi	serine carboxypeptidase S28, putative	0.0025	0.017	0.4878
Trichomonas vaginalis	lysosomal pro-X carboxypeptidase, putative	0.0025	0.017	0.0694
Echinococcus granulosus	expressed conserved protein	0.0091	0.0774	0.0764
Echinococcus granulosus	tar DNA binding protein	0.0062	0.051	0.0501
Onchocerca volvulus		0.0186	0.1645	1
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0155	0.136	0.1351
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.0025	0.017	0.0694
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.004	0.0313	0.2302
Echinococcus granulosus	carboxylesterase 5A	0.1103	1	1
Schistosoma mansoni	cpg binding protein	0.0028	0.0202	0.0192
Giardia lamblia	Rab geranylgeranyltransferase	0.0155	0.136	1
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.017	0.0694
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.017	0.0694
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0431	0.4338
Schistosoma mansoni	topbp1	0.001	0.0034	0.0024
Brugia malayi	topoisomerase	0.001	0.0034	0.0034
Mycobacterium ulcerans	glutaminase	0.0268	0.2392	1
Echinococcus multilocularis	carboxylesterase 5A	0.1103	1	1
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0186	0.1645	0.6873
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0186	0.1645	0.1637
Brugia malayi	Serine protease Z688.6 precursor	0.0025	0.017	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0034	0.0124
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0186	0.1645	0.1637
Echinococcus granulosus	acetylcholinesterase	0.1103	1	1
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.004	0.0313	0.0303
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0034	0.0124
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	0.0112	0.0971	0.0962
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0186	0.1645	0.5
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0971	0.0971
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0112	0.0971	0.0962
Toxoplasma gondii	hypothetical protein	0.004	0.0313	0.3151
Brugia malayi	Carboxylesterase family protein	0.0186	0.1645	0.1645
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.004	0.0313	0.0303
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.004	0.0313	0.1292
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.004	0.0313	1
Schistosoma mansoni	hypothetical protein	0.004	0.0311	0.0301
Loa Loa (eye worm)	carboxylesterase	0.0186	0.1645	0.1645
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0026	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0051	0.041	0.041
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0325	0.0315
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.0025	0.017	0.0694
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.004	0.0313	0.0303
Schistosoma mansoni	DNA ligase IV	0.001	0.0034	0.0024
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.004	0.0313	0.0313
Schistosoma mansoni	hypothetical protein	0.004	0.0311	0.0301
Schistosoma mansoni	hypothetical protein	0.004	0.0311	0.0301
Onchocerca volvulus		0.0186	0.1645	1
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0155	0.136	0.136
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0034	0.5
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0155	0.136	0.5677
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0155	0.136	0.5677
Loa Loa (eye worm)	hypothetical protein	0.001	0.0034	0.0034
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.0827	0.0818
Loa Loa (eye worm)	carboxylesterase	0.0186	0.1645	0.1645
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0025	0.017	0.1026
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.051	0.0501
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.017	0.0694
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0026	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0325	0.134
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0186	0.1645	0.1637
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.017	0.0694
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0325	0.0325
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.004	0.0313	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0186	0.1645	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.051	0.0501
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0034	0.0124
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0025	0.017	0.016
Echinococcus multilocularis	protein patched	0.0041	0.0325	0.0315
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.004	0.0313	0.0303
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.004	0.0313	0.0313
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1103	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0325	0.0325
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0034	0.0024
Schistosoma mansoni	BC026374 protein (S09 family)	0.0186	0.1645	0.1637
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0025	0.0025
Brugia malayi	glutaminase DH11.1	0.0268	0.2392	0.2392
Trypanosoma cruzi	serine carboxypeptidase S28, putative	0.0025	0.017	0.4878
Echinococcus granulosus	BC026374 protein S09 family	0.0186	0.1645	0.1637
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.004	0.0313	0.2302
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1645	0.1645
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.017	0.0694
Schistosoma mansoni	patched 1	0.0041	0.0325	0.0315
Loa Loa (eye worm)	hypothetical protein	0.001	0.0034	0.0034
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0489	0.0479
Echinococcus granulosus	nibrin	0.001	0.0034	0.0024
Loa Loa (eye worm)	glutaminase	0.0268	0.2392	0.2392
Schistosoma mansoni	topbp1	0.001	0.0034	0.0024
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0025	0.017	0.1026
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0034	0.0124
Giardia lamblia	Rab geranylgeranyltransferase	0.004	0.0313	0.2103
Brugia malayi	hypothetical protein	0.0186	0.1645	0.1645
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0155	0.136	1
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0313	1
Onchocerca volvulus		0.004	0.0313	0.1902
Echinococcus granulosus	dnaJ subfamily B	0.0399	0.3587	0.3581
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.051	0.051
Giardia lamblia	Serine peptidase, putative	0.0025	0.017	0.1026
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0034	0.0124
Loa Loa (eye worm)	glutaminase 2	0.0268	0.2392	0.2392
Toxoplasma gondii	serine carboxypeptidase s28 protein	0.0025	0.017	0.1713
Toxoplasma gondii	hypothetical protein	0.0115	0.0993	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.0827	0.5983
Mycobacterium ulcerans	carboxylesterase, LipT	0.0186	0.1645	0.6834
Schistosoma mansoni	glutaminase	0.0268	0.2392	0.2384
Loa Loa (eye worm)	carboxylesterase	0.1103	1	1
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0034	0.0124
Onchocerca volvulus		0.0186	0.1645	1
Echinococcus multilocularis	nibrin	0.001	0.0034	0.0024
Echinococcus multilocularis	acetylcholinesterase	0.1103	1	1
Brugia malayi	Serine protease Z688.6 precursor	0.0025	0.017	0.017
Brugia malayi	Carboxylesterase family protein	0.0186	0.1645	0.1645
Loa Loa (eye worm)	hypothetical protein	0.001	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0827	0.0827
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0313	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.051	0.0501
Trichomonas vaginalis	glutaminase, putative	0.0268	0.2392	1
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0112	0.0971	0.0962
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0325	0.0315
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0202	0.0202
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0792	0.7164	0.7161
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0034	0.0124
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0313	1
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0155	0.136	0.136
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0034	0.0345
Schistosoma mansoni	acetylcholinesterase	0.0186	0.1645	0.1637
Onchocerca volvulus		0.0186	0.1645	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.136	0.136
Loa Loa (eye worm)	hypothetical protein	0.1103	1	1
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0025	0.017	0.016
Onchocerca volvulus		0.0025	0.017	0.1034
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0186	0.1645	0.1637
Echinococcus granulosus	neuroligin	0.0186	0.1645	0.1637
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0026	0.0026
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0202	0.0202
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0034	0.0124
Echinococcus multilocularis	neuroligin	0.0186	0.1645	0.1637
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0034	0.0124
Chlamydia trachomatis	DNA ligase	0.001	0.0034	0.5
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0034	0.0345
Onchocerca volvulus		0.0186	0.1645	1
Brugia malayi	CHE-14 protein	0.0041	0.0325	0.0325
Schistosoma mansoni	cpg binding protein	0.003	0.0217	0.0207
Onchocerca volvulus		0.0028	0.0202	0.1229
Schistosoma mansoni	hypothetical protein	0.004	0.0311	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1645	0.1645
Echinococcus multilocularis	expressed conserved protein	0.0091	0.0774	0.0764
Brugia malayi	Carboxylesterase family protein	0.1103	1	1
Brugia malayi	Carboxylesterase family protein	0.0186	0.1645	0.1645
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0034	0.0024
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0025	0.017	0.1026
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.004	0.0313	1
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.017	0.0694
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0155	0.136	0.5677
Loa Loa (eye worm)	hypothetical protein	0.001	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1645	0.1645
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.051	0.0501
Echinococcus multilocularis	Niemann Pick C1 protein	0.0138	0.1205	0.1196
Brugia malayi	Serine carboxypeptidase S28 family protein	0.0112	0.0971	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1645	0.1645
Loa Loa (eye worm)	hypothetical protein	0.001	0.0034	0.0034
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0155	0.136	1
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.051	0.051
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.0827	0.0827
Loa Loa (eye worm)	acetylcholinesterase 1	0.1103	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0034	0.0034
Echinococcus multilocularis	acetylcholinesterase	0.1103	1	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0186	0.1645	0.5
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0115	0.0993	0.4142
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1645	0.1645
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.004	0.0313	1
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.004	0.0313	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1645	0.1645
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0034	0.0034
Loa Loa (eye worm)	RNA binding protein	0.0062	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0971	0.0971
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.051	0.0501
Echinococcus granulosus	cpg binding protein	0.003	0.0217	0.0207
Brugia malayi	Carboxylesterase family protein	0.0186	0.1645	0.1645
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.017	0.0694
Treponema pallidum	DNA ligase (lig)	0.001	0.0034	0.5
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0186	0.1645	0.1637
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0034	0.0252
Brugia malayi	TAR-binding protein	0.0062	0.051	0.051
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.004	0.0313	0.2103
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.017	0.0694
Echinococcus granulosus	Niemann Pick C1 protein	0.0138	0.1205	0.1196
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0034	0.0034
Brugia malayi	RNA binding protein	0.0062	0.051	0.051
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.004	0.0313	0.0303
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.004	0.0313	0.5
Trypanosoma cruzi	putative prolyl carboxypeptidase, putative	0.0025	0.017	0.4878
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0325	0.0315
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.0841	0.0832
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.017	0.0694
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0155	0.136	0.1351

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 509 nM	Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis	ChEMBL.	22290078

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1950896

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1597563