Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0008 | 0.0009 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 1.0917 | 0.9649 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0022 | 0.0004 | 0.0003 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.8187 | 0.7232 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.4309 | 0.3799 | 0.3799 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0022 | 0.0023 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0066 | 0.0043 | 0.0043 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0022 | 0.0004 | 0.0003 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0464 | 0.0395 | 0.0394 |
Leishmania major | dihydrolipoamide acetyltransferase precursor, putative | 0.0396 | 0.0335 | 0.0334 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.7004 | 0.6185 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.0036 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0022 | 0.0004 | 0.0004 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0396 | 0.0335 | 0.0347 |
Toxoplasma gondii | 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein | 0.0396 | 0.0335 | 0.0334 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.0004 | 0.0003 |
Toxoplasma gondii | dihydrolipoamide acyltransferase, putative | 0.0396 | 0.0335 | 0.0334 |
Echinococcus multilocularis | dihydrolipoyllysine residue succinyltransferase | 0.0396 | 0.0335 | 0.0334 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0022 | 0.0004 | 0.0003 |
Mycobacterium leprae | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) | 0.1533 | 0.1342 | 0.2905 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.4309 | 0.3799 | 0.3799 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0022 | 0.0004 | 0.0003 |
Echinococcus granulosus | FTZ F1 alpha | 0.0022 | 0.0004 | 0.0003 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0022 | 0.0004 | 0.0003 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0022 | 0.0004 | 0.0003 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase precursor, putative | 0.0396 | 0.0335 | 0.054 |
Brugia malayi | MAP kinase sur-1 | 0.0059 | 0.0036 | 0.0036 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E2 | 0.0396 | 0.0335 | 0.0334 |
Onchocerca volvulus | 0.0027 | 0.0008 | 0.0525 | |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.4309 | 0.3799 | 0.3799 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.4309 | 0.3799 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0059 | 0.0036 | 0.0035 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.0043 | 0.0042 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0022 | 0.0004 | 0.0003 |
Plasmodium falciparum | carbamoyl phosphate synthetase | 0.0974 | 0.0847 | 0.1169 |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0.0004 | 0.0003 |
Mycobacterium ulcerans | acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 | 0.1533 | 0.1342 | 0.3529 |
Plasmodium falciparum | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex | 0.0396 | 0.0335 | 0.0462 |
Echinococcus granulosus | propionyl coenzyme A carboxylase beta chain | 0.1533 | 0.1342 | 0.1341 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 1.1314 | 1 | 1 |
Schistosoma mansoni | dihydrolipoamide S-acetyltransferase | 0.0396 | 0.0335 | 0.0334 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.0004 | 0.0003 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.8187 | 0.7232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0396 | 0.0335 | 0.0347 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.4309 | 0.3799 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 1.1314 | 1 | 1 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.4309 | 0.3799 | 0.3799 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.4309 | 0.3799 | 0.6142 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0002 | 0.0001 |
Plasmodium vivax | carbamoyl phosphate synthetase, putative | 0.0974 | 0.0847 | 0.1169 |
Mycobacterium tuberculosis | Biotinylated protein TB7.3 | 0.0396 | 0.0335 | 0.088 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.4309 | 0.3799 | 0.6142 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.0004 | 0.0003 |
Schistosoma mansoni | propionyl-CoA carboxylase beta chain mitochondrial precursor | 0.1533 | 0.1342 | 0.1341 |
Toxoplasma gondii | carbamoylphosphate synthetase | 0.0974 | 0.0847 | 0.0846 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0008 | 0.0007 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.0004 | 0.0003 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.1533 | 0.1342 | 0.2168 |
Trypanosoma cruzi | glutamine dependent carbamoyl-phosphate synthase, putative | 0.0974 | 0.0847 | 0.1367 |
Plasmodium vivax | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative | 0.0396 | 0.0335 | 0.0462 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.4309 | 0.3799 | 1 |
Leishmania major | dihydrolipoamide acetyltransferase precursorlike protein | 0.0396 | 0.0335 | 0.0334 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0004 | 0.0003 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0022 | 0.0004 | 0.0003 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0004 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0004 | 0.0004 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.4309 | 0.3799 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0464 | 0.0395 | 0.0394 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0059 | 0.0036 | 0.0037 |
Mycobacterium tuberculosis | Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 | 0.1533 | 0.1342 | 0.3529 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0059 | 0.0036 | 0.0035 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0031 | 0.003 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0022 | 0.0004 | 0.0004 |
Mycobacterium ulcerans | acetyl-/propionyl-CoA carboxylase subunit beta | 0.1533 | 0.1342 | 0.3529 |
Brugia malayi | Carboxyl transferase domain containing protein | 1.0917 | 0.9649 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.0093 | 1 |
Chlamydia trachomatis | acetyl-coenzyme A carboxylase carboxyl transferase subunit beta | 0.1533 | 0.1342 | 0.3233 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0059 | 0.0036 | 0.0208 |
Schistosoma mansoni | lamin | 0.0027 | 0.0008 | 0.0007 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0004 | 0.0003 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0022 | 0.0004 | 0.0004 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0022 | 0.0004 | 0.0003 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0002 | 0.0001 |
Mycobacterium ulcerans | acetyl/propionyl CoA carboxylase subunit beta | 0.1533 | 0.1342 | 0.3529 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.0043 | 0.0068 |
Schistosoma mansoni | coup transcription factor | 0.0022 | 0.0004 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0396 | 0.0335 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0004 | 0.0004 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0031 | 0.0031 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase precursor, putative | 0.0396 | 0.0335 | 0.054 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0066 | 0.0043 | 0.0248 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0003 | 0.0003 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.0043 | 0.0042 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0022 | 0.0004 | 0.0003 |
Toxoplasma gondii | dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase | 0.0396 | 0.0335 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0004 | 0.0004 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0059 | 0.0036 | 0.0057 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.4309 | 0.3799 | 0.3799 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0022 | 0.0004 | 0.0003 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0022 | 0.0004 | 0.0003 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.4309 | 0.3799 | 1 |
Leishmania major | dihydrolipoamide branched chain transacylase, putative | 0.0396 | 0.0335 | 0.0334 |
Echinococcus multilocularis | dihydrolipoyllysine residue acetyltransferase | 0.0396 | 0.0335 | 0.0334 |
Echinococcus granulosus | dihydrolipoyllysine residue acetyltransferase | 0.0396 | 0.0335 | 0.0334 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0022 | 0.0004 | 0.0003 |
Schistosoma mansoni | dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase | 0.0396 | 0.0335 | 0.0334 |
Trypanosoma brucei | dihydrolipoamide acetyltransferase E2 subunit, putative | 0.0396 | 0.0335 | 0.0334 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0059 | 0.0036 | 0.0057 |
Trypanosoma brucei | acetyl-CoA carboxylase | 1.1314 | 1 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.0018 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0093 | 0.0097 |
Mycobacterium leprae | ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 | 0.1533 | 0.1342 | 0.2905 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0.0004 | 0.0003 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0031 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0018 | 0.0019 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase, putative | 0.0396 | 0.0335 | 0.054 |
Mycobacterium tuberculosis | DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase | 0.0396 | 0.0335 | 0.088 |
Trypanosoma brucei | glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative | 0.0974 | 0.0847 | 0.0846 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0002 | 0.0001 |
Toxoplasma gondii | acyl-CoA carboxyltransferase beta chain, putative | 0.1533 | 0.1342 | 0.1341 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0022 | 0.0004 | 0.0003 |
Schistosoma mansoni | dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase | 0.0396 | 0.0335 | 0.0334 |
Toxoplasma gondii | biotin-requiring enzyme domain-containing protein | 0.0396 | 0.0335 | 0.0334 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0031 | 0.003 |
Mycobacterium ulcerans | branched-chain alpha-keto acid dehydrogenase subunit E2 | 0.0396 | 0.0335 | 0.088 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0059 | 0.0036 | 0.0035 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.0043 | 0.0042 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0022 | 0.0004 | 0.0003 |
Plasmodium falciparum | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex | 0.0396 | 0.0335 | 0.0462 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.1929 | 0.1692 | 1 |
Trypanosoma cruzi | dihydrolipoamide branched chain transacylase, putative | 0.0396 | 0.0335 | 0.054 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0059 | 0.0036 | 0.0057 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.0043 | 0.0042 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.4309 | 0.3799 | 0.3799 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0008 | 0.0009 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.0004 | 0.0003 |
Leishmania major | acetyl-CoA carboxylase, putative | 1.1314 | 1 | 1 |
Schistosoma mansoni | acetyl-CoA carboxylase | 1.1314 | 1 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0396 | 0.0335 | 0.0334 |
Brugia malayi | hypothetical protein | 0.0123 | 0.0093 | 0.0096 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0008 | 0.0008 |
Brugia malayi | nuclear hormone receptor | 0.0022 | 0.0004 | 0.0003 |
Mycobacterium ulcerans | dihydrolipoamide acetyltransferase | 0.0396 | 0.0335 | 0.088 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0022 | 0.0004 | 0.0003 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0022 | 0.0004 | 0.0003 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0022 | 0.0004 | 0.0003 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.0974 | 0.0847 | 0.0846 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.0004 | 0.0003 |
Echinococcus granulosus | neuropeptide s receptor | 0.0464 | 0.0395 | 0.0394 |
Brugia malayi | nuclear receptor NHR-88 | 0.0022 | 0.0004 | 0.0003 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0031 | 0.003 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0059 | 0.0036 | 0.0035 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide acyltransferase E2 component | 0.0396 | 0.0335 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0004 | 0.0004 |
Mycobacterium tuberculosis | Probable branched-chain keto acid dehydrogenase E2 component BkdC | 0.0396 | 0.0335 | 0.088 |
Schistosoma mansoni | lamin | 0.0027 | 0.0008 | 0.0007 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0022 | 0.0004 | 0.0003 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.0036 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.0043 | 0.0045 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0022 | 0.0004 | 0.0004 |
Trypanosoma cruzi | dihydrolipoamide branched chain transacylase, putative | 0.0396 | 0.0335 | 0.054 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.0974 | 0.0847 | 0.0846 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0004 | 0.0004 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.4309 | 0.3799 | 0.3799 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.0006 | 0.0006 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0016 | 0.0015 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0022 | 0.0004 | 0.0003 |
Onchocerca volvulus | 0.0027 | 0.0008 | 0.0525 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.0036 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0008 | 0.0007 |
Leishmania major | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.1533 | 0.1342 | 0.1341 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0059 | 0.0036 | 0.0035 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0.0004 | 0.0003 |
Wolbachia endosymbiont of Brugia malayi | Acetyl-CoA carboxylase, carboxyltransferase component | 0.1533 | 0.1342 | 0.3529 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0003 | 0.0002 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0022 | 0.0004 | 0.0004 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.1533 | 0.1342 | 0.2168 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0022 | 0.0004 | 0.0003 |
Leishmania major | carbamoyl-phosphate synthase, putative | 0.0974 | 0.0847 | 0.0846 |
Trypanosoma brucei | unspecified product | 0.2833 | 0.2492 | 0.2492 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.0036 | 1 |
Brugia malayi | Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor | 0.0396 | 0.0335 | 0.0346 |
Trypanosoma cruzi | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0396 | 0.0335 | 0.054 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0022 | 0.0004 | 0.0003 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0022 | 0.0004 | 0.0004 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0059 | 0.0036 | 0.0035 |
Leishmania major | carboxylase, putative | 0.4309 | 0.3799 | 0.3799 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0059 | 0.0036 | 0.0035 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.0004 | 0.0003 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0031 | 0.003 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0932 | 0.0809 | 0.0808 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0029 | 0.003 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4 | 0.1533 | 0.1342 | 0.3529 |
Plasmodium vivax | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative | 0.0396 | 0.0335 | 0.0462 |
Schistosoma mansoni | pyruvate carboxylase | 0.4309 | 0.3799 | 0.3799 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0015 | 0.0014 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0031 | 0.0032 |
Mycobacterium tuberculosis | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) | 0.1533 | 0.1342 | 0.3529 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0004 | 0.0004 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.0004 | 0.0003 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0059 | 0.0036 | 0.0057 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0022 | 0.0004 | 0.0003 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.0093 | 1 |
Echinococcus granulosus | Biotin lipoyl attachment | 0.0396 | 0.0335 | 0.0334 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0059 | 0.0036 | 0.0035 |
Brugia malayi | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta | 0.0396 | 0.0335 | 0.0346 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0059 | 0.0036 | 0.0035 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0022 | 0.0004 | 0.0003 |
Echinococcus granulosus | lamin | 0.0027 | 0.0008 | 0.0007 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0016 | 0.0015 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0031 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0015 | 0.0015 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 5 AccD5 | 0.1533 | 0.1342 | 0.3529 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0022 | 0.0004 | 0.0003 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0008 | 0.0007 |
Echinococcus multilocularis | Biotin lipoyl attachment | 0.0396 | 0.0335 | 0.0334 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0.0004 | 0.0003 |
Treponema pallidum | pyruvate carboxylase subunit B | 0.0396 | 0.0335 | 1 |
Trypanosoma brucei | dihydrolipoamide branched chain transacylase, putative | 0.0396 | 0.0335 | 0.0334 |
Chlamydia trachomatis | biotin carboxylase | 0.3913 | 0.3449 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0022 | 0.0004 | 0.0004 |
Trypanosoma brucei | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.1533 | 0.1342 | 0.1341 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0047 | 0.0049 |
Trypanosoma brucei | protein kinase, putative | 0.0059 | 0.0036 | 0.0035 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase beta chain | 0.1533 | 0.1342 | 0.1341 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0093 | 0.0097 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0464 | 0.0395 | 0.0394 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0015 | 0.0014 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 1.1314 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | carbamoyl phosphate synthase large subunit | 0.0974 | 0.0847 | 0.2226 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0029 | 0.003 |
Mycobacterium ulcerans | carbamoyl phosphate synthase large subunit | 0.0974 | 0.0847 | 0.2226 |
Trypanosoma brucei | 2-oxoglutarate dehydrogenase E2 component, putative | 0.0396 | 0.0335 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0004 | 0.0004 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.0004 | 0.0003 |
Schistosoma mansoni | dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase | 0.0396 | 0.0335 | 0.0334 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0029 | 0.0029 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0022 | 0.0004 | 0.0003 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.0041 | 0.004 |
Brugia malayi | dihydrolipoamide S-acetyltransferase precursor, putative | 0.0396 | 0.0335 | 0.0346 |
Trypanosoma cruzi | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0396 | 0.0335 | 0.054 |
Trypanosoma brucei | pyruvate dehydrogenase complex E3 binding protein, putative | 0.0396 | 0.0335 | 0.0334 |
Schistosoma mansoni | aspartate carbamoyltransferase | 0.0974 | 0.0847 | 0.0846 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0022 | 0.0004 | 0.0003 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0029 | 0.0029 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0022 | 0.0004 | 0.0003 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0008 | 0.0007 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.0018 | 0.0017 |
Mycobacterium leprae | Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) | 0.1533 | 0.1342 | 0.2905 |
Wolbachia endosymbiont of Brugia malayi | branched-chain alpha-keto acid dehydrogenase subunit E2 | 0.0396 | 0.0335 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0004 | 0.0004 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0066 | 0.0043 | 0.0042 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.4309 | 0.3799 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0022 | 0.0004 | 0.0003 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0008 | 0.0007 |
Brugia malayi | Bromodomain containing protein | 0.0075 | 0.0051 | 0.0052 |
Mycobacterium ulcerans | hypothetical protein | 0.0396 | 0.0335 | 0.088 |
Plasmodium falciparum | dihydrolipoamide acyltransferase component E2 | 0.0396 | 0.0335 | 0.0462 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.0043 | 0.0068 |
Trypanosoma cruzi | glutamine-dependent carbamoyl-phosphate synthetase, putative | 0.0974 | 0.0847 | 0.1367 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.4309 | 0.3799 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0008 | 0.0009 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.0004 | 0.0003 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0001 | 0.0001 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0008 | 0.0007 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.0004 | 0.0003 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.4309 | 0.3799 | 1 |
Echinococcus granulosus | dihydrolipoyllysine residue succinyltransferase | 0.0396 | 0.0335 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0008 | 0.0008 |
Trypanosoma cruzi | acetyl-CoA carboxylase, putative | 0.1533 | 0.1342 | 0.2168 |
Leishmania major | propionyl-coa carboxylase beta chain, putative | 0.1533 | 0.1342 | 0.1341 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.0037 | 0.0036 |
Toxoplasma gondii | pyruvate carboxylase | 0.4309 | 0.3799 | 0.3799 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0022 | 0.0004 | 0.0004 |
Brugia malayi | steroid hormone receptor | 0.0022 | 0.0004 | 0.0003 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.0037 | 0.0036 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0022 | 0.0004 | 0.0003 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.1929 | 0.1692 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0031 | 0.003 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4_2 | 0.1533 | 0.1342 | 0.3529 |
Brugia malayi | ecdysteroid receptor | 0.0022 | 0.0004 | 0.0003 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 5 ug ml-1 | Cytotoxic concentration required to reduce CEM cell viability by 50% | ChEMBL. | 8709116 |
CC50 (ADMET) | = 5 ug ml-1 | Cytotoxic concentration required to reduce CEM cell viability by 50% | ChEMBL. | 8709116 |
CC50 (ADMET) | = 40 ug ml-1 | Cytotoxic concentration required to cause microscopically detecetable alteration of normal cell morphology of E6SM cells | ChEMBL. | 8709116 |
CC50 (ADMET) | = 40 ug ml-1 | Cytotoxic concentration required to cause microscopically detecetable alteration of normal cell morphology of Vero cells | ChEMBL. | 8709116 |
CC50 (ADMET) | = 40 ug ml-1 | Cytotoxic concentration required to cause microscopically detecetable alteration of normal cell morphology of HeLa cells | ChEMBL. | 8709116 |
CC50 (ADMET) | = 40 ug ml-1 | Cytotoxic concentration required to cause microscopically detecetable alteration of normal cell morphology of E6SM cells | ChEMBL. | 8709116 |
CC50 (ADMET) | = 40 ug ml-1 | Cytotoxic concentration required to cause microscopically detecetable alteration of normal cell morphology of HeLa cells | ChEMBL. | 8709116 |
MCC (ADMET) | = 30 ug ml-1 | Minimum cytotoxic concentration to reduce the HEL cell proleferation by 50% | ChEMBL. | 8709116 |
MCC (ADMET) | = 30 ug ml-1 | Minimum cytotoxic concentration to reduce the HEL cell proleferation by 50% | ChEMBL. | 8709116 |
MIC (functional) | > 1 ug ml-1 | Minimum Inhibition Concentration (MIC) of the compound was tested for activity against Cytomegalovirus (CMV) using AD169 strain | ChEMBL. | 8709116 |
MIC (functional) | = 1.8 ug ml-1 | Minimum Inhibition Concentration (MIC) of the compound was tested for activity against Varicella-Zoster Virus(VZV) using YS(TK+) strain. | ChEMBL. | 8709116 |
MIC (functional) | = 2 ug ml-1 | Minimum Inhibition Concentration (MIC) of the compound was tested for activity against Cytomegalovirus (CMV) using Davis strain | ChEMBL. | 8709116 |
MIC (functional) | = 2 ug ml-1 | Minimum Inhibition Concentration( MIC) of the compound was tested for activity against Varicella-Zoster Virus(VZV) using YS/R (TK-) strain. | ChEMBL. | 8709116 |
MIC (functional) | = 2.3 ug ml-1 | Minimum Inhibition Concentration (MIC) of the compound was tested for activity against Varicella-Zoster Virus(VZV) using 07/1 (TK-) strain. | ChEMBL. | 8709116 |
MIC (functional) | = 2.7 ug ml-1 | Minimum Inhibition Concentration (MIC) of the compound was tested for activity against Varicella-Zoster Virus(VZV) using OKA (TK+) strain | ChEMBL. | 8709116 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.