Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melatonin receptor 1B | Starlite/ChEMBL | References |
Gallus gallus | Melatonin receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Melatonin receptor | 346 aa | 302 aa | 19.2 % | |
Schistosoma mansoni | opsin-like receptor | Melatonin receptor | 346 aa | 327 aa | 23.5 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Melatonin receptor | 346 aa | 323 aa | 22.0 % |
Brugia malayi | putative neuropeptide receptor NPR1 | Melatonin receptor | 346 aa | 295 aa | 25.8 % |
Schistosoma mansoni | adenoreceptor | Melatonin receptor | 346 aa | 309 aa | 24.3 % |
Echinococcus multilocularis | G-protein coupled receptor, putative | Melatonin receptor | 346 aa | 295 aa | 20.0 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 307 aa | 21.5 % | |
Loa Loa (eye worm) | hypothetical protein | Melatonin receptor | 346 aa | 325 aa | 25.8 % |
Echinococcus multilocularis | allatostatin A receptor | Melatonin receptor | 346 aa | 325 aa | 21.2 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Melatonin receptor | 346 aa | 288 aa | 28.8 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Melatonin receptor | 346 aa | 298 aa | 21.5 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 309 aa | 18.8 % | |
Schistosoma mansoni | neuropeptide receptor | Melatonin receptor | 346 aa | 290 aa | 27.6 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 297 aa | 23.9 % | |
Onchocerca volvulus | Melatonin receptor | 346 aa | 285 aa | 26.7 % | |
Onchocerca volvulus | Melatonin receptor | 346 aa | 330 aa | 21.8 % | |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Melatonin receptor | 346 aa | 315 aa | 24.8 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Melatonin receptor | 346 aa | 307 aa | 21.2 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 300 aa | 23.0 % | |
Brugia malayi | G-protein coupled receptor | Melatonin receptor | 346 aa | 313 aa | 24.0 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 308 aa | 22.1 % | |
Schistosoma mansoni | neuropeptide receptor | Melatonin receptor | 346 aa | 284 aa | 21.1 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 298 aa | 20.5 % | |
Loa Loa (eye worm) | neuropeptide F receptor | Melatonin receptor | 346 aa | 299 aa | 20.1 % |
Candida albicans | similar to S. cerevisiae a-factor receptor STE3 (YKL178C) | Melatonin receptor | 346 aa | 291 aa | 24.4 % |
Echinococcus granulosus | neuropeptide receptor | Melatonin receptor | 346 aa | 303 aa | 29.7 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 279 aa | 23.7 % | |
Onchocerca volvulus | Putative beta-1,3-glucuronyltransferase | Melatonin receptor | 346 aa | 363 aa | 22.9 % |
Schistosoma japonicum | Alpha-1A adrenergic receptor, putative | Melatonin receptor | 346 aa | 325 aa | 22.8 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Melatonin receptor | 346 aa | 323 aa | 22.0 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Melatonin receptor | 346 aa | 349 aa | 23.2 % |
Schistosoma japonicum | Rhodopsin, putative | Melatonin receptor | 346 aa | 285 aa | 27.0 % |
Candida albicans | similar to S. cerevisiae a-factor receptor STE3 (YKL178C) | Melatonin receptor | 346 aa | 291 aa | 24.4 % |
Brugia malayi | GnHR receptor homolog | Melatonin receptor | 346 aa | 310 aa | 21.3 % |
Echinococcus granulosus | allatostatin A receptor | Melatonin receptor | 346 aa | 325 aa | 20.9 % |
Onchocerca volvulus | Phospholipase d-related homolog | Melatonin receptor | 346 aa | 295 aa | 19.7 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 343 aa | 22.4 % | |
Echinococcus granulosus | tachykinin peptides receptor 99D | Melatonin receptor | 346 aa | 308 aa | 23.1 % |
Brugia malayi | hypothetical protein | melatonin receptor 1B | 362 aa | 329 aa | 18.8 % |
Onchocerca volvulus | E3 ubiquitin-protein ligase rpm-1 homolog | Melatonin receptor | 346 aa | 307 aa | 22.1 % |
Loa Loa (eye worm) | hypothetical protein | Melatonin receptor | 346 aa | 292 aa | 25.3 % |
Echinococcus multilocularis | neuropeptide receptor | Melatonin receptor | 346 aa | 303 aa | 28.7 % |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | Melatonin receptor | 346 aa | 340 aa | 22.6 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Melatonin receptor | 346 aa | 350 aa | 23.4 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 52 nM | Inhibition of 2-[125I]-iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina. | ChEMBL. | 8411005 |
IC50 (functional) | = 52 nM | Inhibition of 2-[125I]-iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina. | ChEMBL. | 8411005 |
Ki (binding) | = 665 nM | Binding affinity to compete for 2-[125I]-iodomelatonin binding to chicken retinal membranes | ChEMBL. | 8411005 |
Ki (binding) | = 665 nM | Binding affinity to compete for 2-[125I]-iodomelatonin binding to chicken retinal membranes | ChEMBL. | 8411005 |
pRA (binding) | = -3.07 | Negative logarithm of relative affinity (pRA) towards melatonin receptor (relative to N-actyl-5-methoxytryptamine (aMT)) | ChEMBL. | 9748358 |
Relative affinity (binding) | = 1170 | Relative binding affinity to chicken retinal membranes compared to 2-[125I]-iodomelatonin. | ChEMBL. | 8411005 |
Relative potency (functional) | = 3060 | Relative potency of inhibition of calcium-dependent release of [3H]-dopamine from rabbit retina caused by 2-[125I]-iodomelatonin. | ChEMBL. | 8411005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.