Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0382 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0382 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0382 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0382 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0042 | 0.0107 | 0.0107 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0042 | 0.0107 | 0.0107 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.4114 | 0.4114 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0042 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | ecdysteroid receptor | 0.0042 | 0.0107 | 0.0107 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0186 | 0.0186 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0382 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0042 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | nuclear receptor NHR-88 | 0.0042 | 0.0107 | 0.0107 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0042 | 0.0107 | 0.0107 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0042 | 0.0107 | 0.0107 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0042 | 0.0107 | 0.0107 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.018 | 0.4114 | 0.4114 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2592 | 0.2592 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0186 | 0.0186 |
Brugia malayi | nuclear hormone receptor | 0.0042 | 0.0107 | 0.0107 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.018 | 0.4114 | 0.4114 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0042 | 0.0107 | 0.0107 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0042 | 0.0107 | 0.0107 |
Echinococcus granulosus | carbonic anhydrase | 0.018 | 0.4114 | 0.4114 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.018 | 0.4114 | 0.4114 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0042 | 0.0107 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0301 | 0.0301 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0301 | 0.0301 |
Echinococcus multilocularis | geminin | 0.0164 | 0.3664 | 0.3664 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.2592 | 0.2592 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0301 | 0.0301 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0382 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4114 | 0.4114 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0186 | 0.0186 |
Onchocerca volvulus | 0.0042 | 0.0107 | 1 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0382 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.018 | 0.4114 | 0.4114 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0042 | 0.0107 | 0.0107 |
Leishmania major | carbonic anhydrase-like protein | 0.0382 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.018 | 0.4114 | 0.4114 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0042 | 0.0107 | 0.0107 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0042 | 0.0107 | 0.0107 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0242 | 0.5928 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.018 | 0.4114 | 0.4114 |
Echinococcus granulosus | FTZ F1 alpha | 0.0042 | 0.0107 | 0.0107 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0042 | 0.0107 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.018 | 0.4114 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2592 | 0.2592 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0186 | 0.0186 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0042 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0107 | 0.0107 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.2592 | 0.2592 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4114 | 0.4114 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0186 | 0.0186 |
Echinococcus granulosus | carbonic anhydrase | 0.018 | 0.4114 | 0.4114 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2592 | 0.2592 |
Schistosoma mansoni | carbonic anhydrase | 0.018 | 0.4114 | 0.4114 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.2592 | 0.2592 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0042 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0042 | 0.0107 | 0.0107 |
Schistosoma mansoni | thyroid hormone receptor | 0.0042 | 0.0107 | 0.0107 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0186 | 0.0186 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0042 | 0.0107 | 0.0107 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0382 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0042 | 0.0107 | 0.0107 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.3664 | 0.3664 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0301 | 0.0301 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0127 | 0.2592 | 0.2592 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0042 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0042 | 0.0107 | 0.0107 |
Echinococcus multilocularis | carbonic anhydrase | 0.018 | 0.4114 | 0.4114 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0042 | 0.0107 | 0.0107 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0042 | 0.0107 | 0.0107 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.3664 | 0.3664 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0042 | 0.0107 | 0.0107 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.2592 | 0.2592 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0382 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0042 | 0.0107 | 0.0107 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0042 | 0.0107 | 0.0107 |
Schistosoma mansoni | carbonic anhydrase-related | 0.018 | 0.4114 | 0.4114 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0042 | 0.0107 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.018 | 0.4114 | 0.4114 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | steroid hormone receptor | 0.0042 | 0.0107 | 0.0107 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0042 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0042 | 0.0107 | 0.0107 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0042 | 0.0107 | 0.0107 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0042 | 0.0107 | 0.0107 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0186 | 0.0186 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.2592 | 0.2592 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0042 | 0.0107 | 0.0107 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0042 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0382 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0042 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0042 | 0.0107 | 0.0107 |
Schistosoma mansoni | nuclear hormone receptor | 0.0042 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.2592 | 0.2592 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.2592 | 0.2592 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.018 | 0.4114 | 0.4114 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0042 | 0.0107 | 0.0107 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0042 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0107 | 0.0107 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0186 | 0.0186 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0042 | 0.0107 | 0.0107 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0042 | 0.0107 | 0.0107 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0042 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.018 | 0.4114 | 0.4114 |
Schistosoma mansoni | coup transcription factor | 0.0042 | 0.0107 | 0.0107 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.018 | 0.4114 | 0.4114 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0042 | 0.0107 | 0.0107 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2592 | 0.2592 |
Echinococcus granulosus | geminin | 0.0164 | 0.3664 | 0.3664 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0186 | 0.0186 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.018 | 0.4114 | 0.4114 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0042 | 0.0107 | 0.0107 |
Toxoplasma gondii | hypothetical protein | 0.018 | 0.4114 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4114 | 0.4114 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2592 | 0.2592 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.34 uM | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 harboring pFCA-lux AB gene measured under aerobic condition after 8 days by luminescence analysis | ChEMBL. | 22148391 |
MIC (functional) | = 4.3 uM | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 harboring pFCA-lux AB gene measured under anaerobic condition after 11 days by luminescence analysis | ChEMBL. | 22148391 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.