Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | proteasome PrcB | 0.1105 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0859 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.1105 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1105 | 1 | 1 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0532 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0859 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0532 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0532 | 0.3546 | 0.3546 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.1105 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0532 | 0.3546 | 0.3546 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0532 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0532 | 0.3546 | 0.3546 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0921 | 0.7931 | 0.7931 |
Leishmania major | proteasome beta 5 subunit, putative | 0.1105 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0532 | 0.3546 | 0.3546 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0921 | 0.7931 | 0.7931 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.1105 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.1105 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.1105 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.1105 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0532 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0859 | 0.7224 | 0.7224 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0217 | 0 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.1105 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0859 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0532 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0859 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0859 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1105 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0532 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.1105 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0532 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0859 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0859 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0859 | 0.7224 | 0.7224 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.1105 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0859 | 0.7224 | 0.7224 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0921 | 0.7931 | 0.7931 |
Onchocerca volvulus | Notchless protein homolog | 0.0217 | 0 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0921 | 0.7931 | 0.7931 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0532 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0532 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.1105 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0859 | 0.7224 | 0.7224 |
Brugia malayi | hypothetical protein | 0.0424 | 0.2325 | 0.2325 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.1105 | 1 | 1 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0532 | 0.3546 | 0.3546 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0859 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0532 | 0.3546 | 0.3546 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.1105 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.1105 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 2 | 0.0532 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0532 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0859 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0859 | 0.7224 | 0.7224 |
Brugia malayi | proteasome subunit beta type 1 | 0.0859 | 0.7224 | 0.7224 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/C (binding) | = 4.85 | Inhibition of dihydrofolate reductase from rat Walker 256 leukaemia tumors | ChEMBL. | 1895302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.