Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0138 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0138 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0138 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0138 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | > 60 % | Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as residual activity at 30 uM relative to control | ChEMBL. | 21341744 |
Activity (binding) | > 60 % | Inhibition of 5-lipoxygenase in S100 supernatant assessed as residual activity at 30 uM relative to control | ChEMBL. | 21341744 |
IC50 (binding) | = 30 uM | Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC method | ChEMBL. | 21341744 |
IC50 (binding) | = 30 uM | Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production preincubated for 15 mins measured after 10 mins by HPLC method | ChEMBL. | 21341744 |
IC50 (binding) | > 30 uM | Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC method | ChEMBL. | 21341744 |
IC50 (binding) | > 30 uM | Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production preincubated for 15 mins measured after 10 mins by HPLC method | ChEMBL. | 21341744 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.