Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.2326 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.2326 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0908 | 0.3132 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0908 | 0.3132 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0908 | 0.3132 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0908 | 0.3132 | 0.5 |
Onchocerca volvulus | 0.0262 | 0 | 0.5 | |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0908 | 0.3132 | 0.3132 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0908 | 0.3132 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.2326 | 1 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.2326 | 1 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.2326 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.2326 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0908 | 0.3132 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0908 | 0.3132 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0908 | 0.3132 | 1 |
Onchocerca volvulus | 0.0262 | 0 | 0.5 | |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2326 | 1 | 1 |
Onchocerca volvulus | 0.0262 | 0 | 0.5 | |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2326 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0908 | 0.3132 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.2326 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.2326 | 1 | 0.5 |
Onchocerca volvulus | 0.0262 | 0 | 0.5 | |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2326 | 1 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.2326 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2326 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.2326 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0908 | 0.3132 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0908 | 0.3132 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.