Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0077 | 0.1413 | 0.1413 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.8385 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.0056 | 0.0028 | 0.0028 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.1413 | 0.2888 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.8385 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0403 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.1413 | 0.2888 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0082 | 0.1741 | 0.205 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0082 | 0.1741 | 0.3521 |
Brugia malayi | Cytochrome P450 family protein | 0.0082 | 0.1741 | 0.1741 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.4893 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.1413 | 0.2888 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.8385 | 1 |
Brugia malayi | cytochrome P450 | 0.0056 | 0.0028 | 0.0028 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0062 | 0.0403 | 0.0771 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0082 | 0.1741 | 0.205 |
Brugia malayi | RNA binding protein | 0.0077 | 0.1413 | 0.1413 |
Onchocerca volvulus | 0.013 | 0.4893 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0062 | 0.0403 | 0.0449 |
Trypanosoma brucei | cytochrome P450, putative | 0.0082 | 0.1741 | 0.205 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.4893 | 0.4893 |
Loa Loa (eye worm) | RNA binding protein | 0.0077 | 0.1413 | 0.1413 |
Leishmania major | cytochrome p450-like protein | 0.0082 | 0.1741 | 0.205 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0077 | 0.1413 | 0.1413 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.4893 | 1 |
Echinococcus multilocularis | 0.0056 | 0.0028 | 0.0057 | |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.4893 | 1 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0403 | 0.0403 |
Brugia malayi | TAR-binding protein | 0.0077 | 0.1413 | 0.1413 |
Echinococcus granulosus | tar DNA binding protein | 0.0077 | 0.1413 | 0.2888 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.4893 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0077 | 0.1413 | 0.1413 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.4893 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0056 | 0.0028 | 0.0028 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0056 | 0.0028 | 0.0057 |
Schistosoma mansoni | cytochrome P450 | 0.0056 | 0.0028 | 0.0057 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.1413 | 0.2888 |
Brugia malayi | thymidylate synthase | 0.013 | 0.4893 | 0.4893 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0082 | 0.1741 | 0.1741 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0028 | 0.0057 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0082 | 0.1741 | 0.1741 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.8385 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.8385 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0082 | 0.1741 | 0.1741 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0207 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.4893 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.1413 | 0.2888 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.8385 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0082 | 0.1741 | 0.1741 |
Echinococcus multilocularis | tar DNA binding protein | 0.0077 | 0.1413 | 0.2888 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 87 ug ml-1 | Cytotoxic concentration required to reduce CEM cell viability by 50% | ChEMBL. | 8709116 |
CC50 (ADMET) | = 87 ug ml-1 | Cytotoxic concentration required to reduce CEM cell viability by 50% | ChEMBL. | 8709116 |
CC50 (ADMET) | > 200 ug ml-1 | Cytotoxic concentration required to cause microscopically detecetable alteration of normal cell morphology of HeLa cells | ChEMBL. | 8709116 |
CC50 (ADMET) | > 200 ug ml-1 | Cytotoxic concentration required to cause microscopically detecetable alteration of normal cell morphology of HeLa cells | ChEMBL. | 8709116 |
CC50 (ADMET) | > 400 ug ml-1 | Cytotoxic concentration required to cause microscopically detecetable alteration of normal cell morphology of E6SM cells | ChEMBL. | 8709116 |
CC50 (ADMET) | > 400 ug ml-1 | Cytotoxic concentration required to cause microscopically detecetable alteration of normal cell morphology of Vero cells | ChEMBL. | 8709116 |
CC50 (ADMET) | > 400 ug ml-1 | Cytotoxic concentration required to cause microscopically detecetable alteration of normal cell morphology of E6SM cells | ChEMBL. | 8709116 |
MCC (ADMET) | > 100 ug ml-1 | Minimum cytotoxic concentration required to reduce human embryonic lung (HEL) cell proleferation by 50% | ChEMBL. | 8709116 |
MCC (ADMET) | > 100 ug ml-1 | Minimum cytotoxic concentration required to reduce human embryonic lung (HEL) cell proleferation by 50% | ChEMBL. | 8709116 |
MIC (functional) | > 25 ug ml-1 | Minimum Inhibitory Concentration(MIC) for activity against Varicella-Zoster Virus(VZV) using OKA (TK+) strain | ChEMBL. | 8709116 |
MIC (functional) | > 25 ug ml-1 | Minimum Inhibition Concentration(MIC) of the compound was tested for activity against Varicella-Zoster Virus(VZV) using YS(TK+) strain. | ChEMBL. | 8709116 |
MIC (functional) | = 25 ug ml-1 | Minimum Inhibitory Concentration (MIC) tested for activity against Varicella-Zoster Virus(VZV) using YS/R (TK-) strain. | ChEMBL. | 8709116 |
MIC (functional) | > 50 ug ml-1 | Minimum Inhibitory Concentration (MIC) tested for activity against Cytomegalovirus(CMV) using AD169 strain | ChEMBL. | 8709116 |
MIC (functional) | > 50 ug ml-1 | Minimum Inhibitory Concentration (MIC) tested for activity against Cytomegalovirus(CMV) using Davis strain | ChEMBL. | 8709116 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.