Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | G protein-coupled receptor 119 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | G protein-coupled receptor 119 | 335 aa | 274 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0068 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0068 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0068 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0068 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0068 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0068 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0068 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0068 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0068 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0068 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0068 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0068 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0068 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0068 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0068 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0068 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0068 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0068 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0068 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0068 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0068 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0068 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0068 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0068 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0068 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0068 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0068 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0068 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0068 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0068 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0068 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0068 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0068 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0068 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0068 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0068 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0068 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0068 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0068 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0068 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0068 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay | ChEMBL. | 22264481 | |
EC50 (functional) | = 2330 nM | Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay | ChEMBL. | 22264481 |
Intrinsic activity (binding) | Intrinsic activity at rat GPR119 receptor assessed as cAMP production by HTRF assay relative to AR231453 | ChEMBL. | 22264481 | |
Intrinsic activity (binding) | = 83 % | Intrinsic activity at human GPR119 receptor assessed as cAMP production by HTRF assay relative to AR231453 | ChEMBL. | 22264481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.