Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0059 | 0.0122 |
Brugia malayi | hypothetical protein | 0.0072 | 0.0765 | 0.1576 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Onchocerca volvulus | 0.0072 | 0.0765 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.0458 | 0.5925 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0007 | 0.002 | 0.0041 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.0812 | 0.1674 |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0072 | 0.0765 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0072 | 0.0765 | 0.1576 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0439 | 0.0905 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0059 | 0.0122 |
Brugia malayi | Patched related family protein 12 | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0059 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0228 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0765 | 0.1576 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0059 | 0.0122 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0059 | 0.0122 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0426 | 0.4854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0059 | 0.0122 |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1156 | 0.2381 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 0.0228 | 0.183 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0228 | 0.2905 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Echinococcus multilocularis | expressed conserved protein | 0.0099 | 0.1082 | 0.1082 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0228 | 1 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0007 | 0.002 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0228 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0059 | 0.0122 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0228 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0059 | 0.0122 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0439 | 0.0905 |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0228 | 0.2791 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Toxoplasma gondii | propionate-CoA ligase | 0.0007 | 0.002 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0576 | 0.1187 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0154 | 0.5 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0007 | 0.002 | 0.0212 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0059 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Onchocerca volvulus | 0.0072 | 0.0765 | 1 | |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0059 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0059 | 0.0122 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0142 | 0.1764 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.0812 | 0.1674 |
Brugia malayi | Carboxylesterase family protein | 0.0426 | 0.4854 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0228 | 0.183 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0072 | 0.0765 | 0.1576 |
Onchocerca volvulus | 0.0007 | 0.002 | 0.0162 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.0059 | 0.0678 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0142 | 0.1764 |
Brugia malayi | CHE-14 protein | 0.0045 | 0.0458 | 0.0944 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0045 | 0.0458 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0298 | 0.0615 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0052 | 0.0532 | 0.1097 |
Onchocerca volvulus | 0.0053 | 0.0548 | 0.7129 | |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0.002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0007 | 0.002 | 0.0844 |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0254 | 0.2869 | 0.2869 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0.002 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.2869 | 0.5911 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.002 | 0.0041 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0059 | 0.0122 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0072 | 0.0765 | 0.1576 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0007 | 0.002 | 0.0844 |
Brugia malayi | hypothetical protein | 0.0254 | 0.2869 | 0.5911 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0228 | 0.2905 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0072 | 0.0765 | 0.1576 |
Echinococcus granulosus | tumor protein p63 | 0.0363 | 0.4128 | 0.8505 |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | Carboxylesterase family protein | 0.0426 | 0.4854 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0108 | 0.1175 | 0.242 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0057 | 0.0587 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0426 | 0.4854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.4854 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0019 | 0.0019 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.0665 | 0.1371 |
Echinococcus granulosus | acetylcholinesterase | 0.0426 | 0.4854 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0812 | 0.1674 |
Loa Loa (eye worm) | patched family protein | 0.0006 | 0.0008 | 0.0016 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0072 | 0.0765 | 0.1576 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0228 | 0.047 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.004 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0059 | 0.0122 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.0812 | 0.0812 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0059 | 0.0059 |
Echinococcus multilocularis | neuroligin | 0.0072 | 0.0765 | 0.0765 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0426 | 0.4854 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0059 | 0.0122 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0059 | 0.0122 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0007 | 0.002 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0059 | 0.0122 |
Onchocerca volvulus | 0.003 | 0.0279 | 0.3577 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0106 | 0.1156 | 0.1156 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.0765 | 0.1576 |
Schistosoma mansoni | acetylcholinesterase | 0.0072 | 0.0765 | 0.1576 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0019 | 0.0019 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0072 | 0.0765 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0059 | 0.0122 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0072 | 0.0765 | 0.1576 |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0812 | 0.1674 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.002 | 0.0041 |
Schistosoma mansoni | survival motor neuron protein | 0.0052 | 0.0532 | 0.1097 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.002 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0765 | 0.1576 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.002 | 0.0041 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.0765 | 0.1576 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0045 | 0.0458 | 0.0944 |
Onchocerca volvulus | 0.0007 | 0.002 | 0.0162 | |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0154 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0059 | 0.0122 |
Echinococcus multilocularis | acetylcholinesterase | 0.0426 | 0.4854 | 0.4854 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0007 | 0.002 | 0.0212 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.0765 | 0.1576 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.0298 | 0.0298 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0155 | 0.1728 | 0.1728 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0228 | 0.2791 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0059 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Echinococcus granulosus | carboxylesterase 5A | 0.0426 | 0.4854 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0426 | 0.4854 | 0.4854 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0007 | 0.002 | 0.0159 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0059 | 0.0122 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0059 | 0.0122 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0072 | 0.0765 | 0.1576 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0059 | 0.0122 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0059 | 0.0122 |
Echinococcus multilocularis | muscleblind protein | 0.0155 | 0.1728 | 0.1728 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0106 | 0.1156 | 1 |
Onchocerca volvulus | 0.0072 | 0.0765 | 1 | |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0059 | 0.0122 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0142 | 0.1764 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0007 | 0.002 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0439 | 0.0905 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.002 | 0.0041 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0007 | 0.002 | 0.0159 |
Brugia malayi | Patched related family protein 10 | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | Patched related family protein 4 | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1728 | 0.356 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0812 | 0.6976 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0.002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0059 | 0.0122 |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0228 | 0.047 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0151 | 0.168 | 0.168 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | oxidoreductase | 0.0007 | 0.002 | 0.0041 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0812 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0458 | 0.0944 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0059 | 0.0122 |
Onchocerca volvulus | 0.0007 | 0.002 | 0.0162 | |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0059 | 0.0059 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0039 | 0.0081 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0439 | 0.0905 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0765 | 0.1576 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0045 | 0.0458 | 0.0944 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0072 | 0.0765 | 1 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.002 | 0.0159 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.0059 | 0.0678 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0154 | 0.0316 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0.002 | 0.5 |
Echinococcus granulosus | expressed conserved protein | 0.0099 | 0.1082 | 0.2229 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0059 | 0.0122 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0059 | 0.0122 |
Loa Loa (eye worm) | patched family protein | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1728 | 0.356 |
Loa Loa (eye worm) | patched family protein | 0.0006 | 0.0008 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0154 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0072 | 0.0765 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0072 | 0.0765 | 0.1576 |
Echinococcus granulosus | muscleblind protein | 0.0155 | 0.1728 | 0.356 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0059 | 0.0122 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0045 | 0.0458 | 0.0944 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0007 | 0.002 | 0.0159 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0007 | 0.002 | 0.0041 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0059 | 0.0122 |
Brugia malayi | Myosin head containing protein | 0.0006 | 0.0008 | 0.0016 |
Echinococcus multilocularis | tumor protein p63 | 0.0363 | 0.4128 | 0.4128 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0059 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0765 | 0.1576 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0548 | 0.1128 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0228 | 0.2791 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0059 | 0.0122 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0228 | 0.2791 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0228 | 0.047 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0279 | 0.0574 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0053 | 0.0548 | 0.1128 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0106 | 0.1156 | 0.2381 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0059 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Echinococcus multilocularis | protein patched | 0.0045 | 0.0458 | 0.0458 |
Loa Loa (eye worm) | patched family protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0059 | 0.0122 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0007 | 0.002 | 0.0159 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0072 | 0.0765 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0059 | 0.0122 |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0059 | 0.0122 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0059 | 0.0059 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0059 | 0.0122 |
Onchocerca volvulus | 0.0011 | 0.0059 | 0.0678 | |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0279 | 0.0574 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0059 | 0.0122 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0059 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0154 | 0.0316 |
Schistosoma mansoni | patched 1 | 0.0045 | 0.0458 | 0.0944 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0059 | 0.0122 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0059 | 0.0122 |
Onchocerca volvulus | 0.0052 | 0.0532 | 0.6928 | |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0279 | 0.0574 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0.002 | 0.5 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Schistosoma mansoni | gliotactin | 0.0072 | 0.0765 | 0.1576 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0059 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0765 | 0.1576 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0426 | 0.4854 | 0.4854 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0059 | 0.0122 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0072 | 0.0765 | 0.0765 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0228 | 0.183 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0154 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0812 | 0.6976 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0072 | 0.0765 | 1 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0007 | 0.002 | 0.0041 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0228 | 0.2791 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.002 | 0.0041 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0019 | 0.0154 | 0.1792 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0059 | 0.0122 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0228 | 0.2791 |
Onchocerca volvulus | 0.0026 | 0.0228 | 0.2908 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0154 | 0.0316 |
Onchocerca volvulus | 0.0072 | 0.0765 | 1 | |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0106 | 0.1156 | 0.2381 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.002 | 0.0159 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.0765 | 0.1576 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0.002 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.002 | 0.0041 |
Brugia malayi | protein C24B5.3 | 0.0006 | 0.0008 | 0.0016 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0812 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0765 | 0.1576 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0059 | 0.0059 |
Brugia malayi | Patched family protein | 0.0006 | 0.0008 | 0.0016 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0532 | 0.1097 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0154 | 0.0316 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0228 | 0.047 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.004 | 0.0083 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.004 | 0.0083 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0019 | 0.004 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0072 | 0.0765 | 0.1576 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0059 | 0.0122 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0059 | 0.0122 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0072 | 0.0765 | 0.0765 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | carboxylesterase | 0.0072 | 0.0765 | 0.1576 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0254 | 0.2869 | 0.5911 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0059 | 0.0122 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0072 | 0.0765 | 0.0765 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0059 | 0.0122 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0142 | 0.1764 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.002 | 0.0041 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0151 | 0.168 | 0.3462 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0059 | 0.0122 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0765 | 0.1576 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0007 | 0.002 | 0.002 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0.002 | 0.5 |
Loa Loa (eye worm) | patched family protein | 0.0006 | 0.0008 | 0.0016 |
Onchocerca volvulus | 0.0072 | 0.0765 | 1 | |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0059 | 0.0122 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.002 | 0.0159 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.002 | 0.0041 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.002 | 0.0159 |
Echinococcus multilocularis | protein dispatched 1 | 0.0052 | 0.0532 | 0.0532 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0059 | 0.0122 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.0298 | 0.0615 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0228 | 0.2791 |
Echinococcus granulosus | acetylcholinesterase | 0.0426 | 0.4854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.4854 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0059 | 0.0122 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0059 | 0.0122 |
Brugia malayi | protein C24B5.3 | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | Patched protein homolog 1 | 0.0006 | 0.0008 | 0.0016 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.0059 | 0.0678 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0059 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0059 | 0.0122 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0059 | 0.0122 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0059 | 0.0122 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0019 | 0.004 |
Brugia malayi | Muscleblind-like protein | 0.0155 | 0.1728 | 0.356 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0008 | 0.0016 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0298 | 0.0615 |
Echinococcus granulosus | neuroligin | 0.0072 | 0.0765 | 0.1576 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0154 | 0.1922 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0228 | 0.2791 |
Onchocerca volvulus | 0.0007 | 0.002 | 0.0162 | |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0019 | 0.004 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0059 | 0.0122 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0007 | 0.002 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0228 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0228 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Imax (binding) | = 38.6 % | Inhibition of COX-2 at 1 mM | ChEMBL. | 22189137 |
Imax (binding) | = 50.5 % | Inhibition of COX-1 at 1 mM | ChEMBL. | 22189137 |
Inhibition (functional) | = 15 % | Antinociceptive activity in Swiss mouse assessed as inhibition of acetic acid induced writhing at 100 mg/kg, po measured every 5 mins for 45 mins | ChEMBL. | 22189137 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.