Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | NAD(P)H dehydrogenase, quinone 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | NAD(P)H dehydrogenase, quinone 2 | 231 aa | 213 aa | 26.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0085 | 0.8252 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0085 | 0.8252 | 1 |
Toxoplasma gondii | beta tubulin | 0.0085 | 0.8252 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0096 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0096 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0085 | 0.8252 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0085 | 0.8252 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0085 | 0.8252 | 1 |
Trypanosoma brucei | beta tubulin | 0.0085 | 0.8252 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0085 | 0.8252 | 1 |
Trypanosoma brucei | beta tubulin | 0.0085 | 0.8252 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0085 | 0.8252 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0085 | 0.8252 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0096 | 1 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0085 | 0.8252 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0085 | 0.8252 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0085 | 0.8252 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0085 | 0.8252 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0085 | 0.8252 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0085 | 0.8252 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Giardia lamblia | Beta tubulin | 0.0085 | 0.8252 | 0.8252 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0085 | 0.8252 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0085 | 0.8252 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0085 | 0.8252 | 0.8252 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0085 | 0.8252 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0085 | 0.8252 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Echinococcus granulosus | beta tubulin | 0.0085 | 0.8252 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0085 | 0.8252 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0096 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0085 | 0.8252 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0085 | 0.8252 | 0.8252 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0085 | 0.8252 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0085 | 0.8252 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Trypanosoma brucei | beta tubulin | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0085 | 0.8252 | 0.8252 |
Giardia lamblia | Beta tubulin | 0.0085 | 0.8252 | 0.8252 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0085 | 0.8252 | 0.8252 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0085 | 0.8252 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0085 | 0.8252 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0085 | 0.8252 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0085 | 0.8252 | 0.8252 |
Echinococcus granulosus | tubulin subunit beta | 0.0085 | 0.8252 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0085 | 0.8252 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0085 | 0.8252 | 1 |
Giardia lamblia | Beta tubulin | 0.0085 | 0.8252 | 0.8252 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0072 | 0.6189 | 0.6189 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0085 | 0.8252 | 0.8252 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0096 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.0085 | 0.8252 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0085 | 0.8252 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0085 | 0.8252 | 1 |
Leishmania major | beta tubulin | 0.0085 | 0.8252 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 88.22 % | Cytotoxicity against human SF539 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 96.95 % | Cytotoxicity against human HOP62 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 98.04 % | Cytotoxicity against human MCF7 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 98.89 % | Cytotoxicity against human SN12C cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 100.09 % | Cytotoxicity against human UACC62 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 101.05 % | Cytotoxicity against human HCT116 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 114.59 % | Cytotoxicity against human DU145 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 115.24 % | Cytotoxicity against human OVCAR3 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
IC50 (binding) | = 0.061 uM | Inhibition of human quinone reductase 2 using NMeH as substrate by MTT assay | ChEMBL. | 22206487 |
Imax (binding) | = 90.3 % | Inhibition of human quinone reductase 2 using NMeH as substrate by MTT assay relative to control | ChEMBL. | 22206487 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.