Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | NAD(P)H dehydrogenase, quinone 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | NAD(P)H dehydrogenase, quinone 2 | 231 aa | 213 aa | 26.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | beta-tubulin, putative | 0.0084 | 0.813 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0072 | 0.6208 | 0.6208 |
Schistosoma mansoni | tubulin subunit beta | 0.0084 | 0.813 | 1 |
Giardia lamblia | Beta tubulin | 0.0084 | 0.813 | 0.813 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0084 | 0.813 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0084 | 0.813 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0084 | 0.813 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0084 | 0.813 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0084 | 0.813 | 0.813 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0084 | 0.813 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0084 | 0.813 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0084 | 0.813 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0084 | 0.813 | 0.813 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Trypanosoma brucei | beta tubulin | 0.0084 | 0.813 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0084 | 0.813 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.0084 | 0.813 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0084 | 0.813 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0084 | 0.813 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0084 | 0.813 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0084 | 0.813 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0084 | 0.813 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0084 | 0.813 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0096 | 1 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0096 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0084 | 0.813 | 0.813 |
Echinococcus multilocularis | tubulin subunit beta | 0.0084 | 0.813 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0084 | 0.813 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0084 | 0.813 | 0.813 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0084 | 0.813 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0084 | 0.813 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0084 | 0.813 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0084 | 0.813 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0084 | 0.813 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0084 | 0.813 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0084 | 0.813 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0084 | 0.813 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0084 | 0.813 | 1 |
Giardia lamblia | Beta tubulin | 0.0084 | 0.813 | 0.813 |
Brugia malayi | beta-tubulin, identical | 0.0084 | 0.813 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0084 | 0.813 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0084 | 0.813 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0084 | 0.813 | 0.813 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0084 | 0.813 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0084 | 0.813 | 0.813 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Trypanosoma brucei | beta tubulin | 0.0084 | 0.813 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0084 | 0.813 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0084 | 0.813 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0084 | 0.813 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0084 | 0.813 | 1 |
Toxoplasma gondii | beta tubulin | 0.0084 | 0.813 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0084 | 0.813 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0096 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0084 | 0.813 | 1 |
Giardia lamblia | Beta tubulin | 0.0084 | 0.813 | 0.813 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0096 | 1 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0096 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Echinococcus granulosus | beta tubulin | 0.0084 | 0.813 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Trypanosoma brucei | beta tubulin | 0.0084 | 0.813 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0084 | 0.813 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0084 | 0.813 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0084 | 0.813 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Leishmania major | beta tubulin | 0.0084 | 0.813 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0084 | 0.813 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 101.7 % | Cytotoxicity against human UACC62 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 102.78 % | Cytotoxicity against human SN12C cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 105.75 % | Cytotoxicity against human MCF7 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 106.32 % | Cytotoxicity against human OVCAR3 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 108.11 % | Cytotoxicity against human DU145 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 108.2 % | Cytotoxicity against human HCT116 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 108.99 % | Cytotoxicity against human HOP62 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
Activity (ADMET) | = 117.31 % | Cytotoxicity against human SF539 cells assessed as cell growth at 10 uM | ChEMBL. | 22206487 |
IC50 (binding) | = 3.3 uM | Inhibition of human quinone reductase 2 using NMeH as substrate by MTT assay | ChEMBL. | 22206487 |
Imax (binding) | = 87.9 % | Inhibition of human quinone reductase 2 using NMeH as substrate by MTT assay relative to control | ChEMBL. | 22206487 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.