TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 234.294 | Formula: C13H18N2O2
H donors: 2 H acceptors: 1 LogP: 1.24 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(NC1COc2c(C1)c(ccc2)C(=O)N)C
InChi: 1S/C13H18N2O2/c1-8(2)15-9-6-11-10(13(14)16)4-3-5-12(11)17-7-9/h3-5,8-9,15H,6-7H2,1-2H3,(H2,14,16)
InChiKey: FVAVMEQKDWJQEM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0023	0.0113	0.0113
Echinococcus granulosus	somatostatin receptor	0.0023	0.0113	0.0124
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0083	0.0118
Trichomonas vaginalis	CMGC family protein kinase	0.0571	0.7033	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0334	0.0475
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0113	0.0124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0113	0.0113
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0023	0.0113	0.0113
Brugia malayi	hypothetical protein	0.0023	0.0113	0.016
Loa Loa (eye worm)	TYRA-2 protein	0.0023	0.0113	0.016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus granulosus	g protein coupled receptor	0.0023	0.0113	0.0124
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0023	0.0113	0.016
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.0113	0.0124
Schistosoma mansoni	myosin xvIII	0.0023	0.0113	0.0124
Brugia malayi	Serotonin receptor	0.0023	0.0113	0.016
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0334	0.0475
Trypanosoma brucei	unspecified product	0.0034	0.0251	0.0357
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0026	0.0038
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0026	0.0038
Schistosoma mansoni	hypothetical protein	0.0125	0.1399	0.1538
Schistosoma mansoni	opsin-like receptor	0.0023	0.0113	0.0124
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0346	0.0381
Brugia malayi	RNA recognition motif domain containing protein	0.0074	0.0748	0.1064
Trichomonas vaginalis	CMGC family protein kinase	0.0571	0.7033	1
Brugia malayi	Melatonin receptor type 1A	0.0023	0.0113	0.016
Brugia malayi	Dopamine receptor	0.0023	0.0113	0.016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0334	0.0475
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0023	0.0113	0.0124
Loa Loa (eye worm)	TAR-binding protein	0.0074	0.0748	0.1064
Echinococcus multilocularis	sex peptide receptor	0.0023	0.0113	0.0113
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0748	0.0822
Loa Loa (eye worm)	G-protein coupled receptor	0.0023	0.0113	0.016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0209	0.0297
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Loa Loa (eye worm)	hypothetical protein	0.003	0.0192	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Brugia malayi	larval opioid receptor	0.0023	0.0113	0.016
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.005	0.0071
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0334	0.0475
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0192	0.0211
Brugia malayi	G protein-coupled receptor F59B2.13	0.0023	0.0113	0.016
Entamoeba histolytica	hypothetical protein	0.0042	0.0346	1
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0748	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus multilocularis	allatostatin A receptor	0.0023	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus granulosus	neuropeptide Y receptor	0.0023	0.0113	0.0124
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0334	0.0475
Schistosoma mansoni	hypothetical protein	0.0018	0.005	0.0055
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0023	0.0113	0.0124
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0571	0.7033	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0113	0.0113
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0334	0.0475
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0734	0.9095	0.9095
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0058	0.055	0.0782
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.0113	0.0113
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0571	0.7033	0.7033
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0571	0.7033	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0192	0.0211
Echinococcus granulosus	neuropeptide Y receptor	0.0023	0.0113	0.0124
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0113	0.0124
Echinococcus multilocularis	serotonin receptor	0.017	0.1972	0.1972
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0023	0.0113	0.0124
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0346	0.0346
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0113	0.0124
Echinococcus granulosus	GPCR family 2	0.0018	0.005	0.0055
Brugia malayi	MAP kinase sur-1	0.0571	0.7033	1
Echinococcus granulosus	g protein coupled receptor	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus granulosus	hypothetical protein	0.0023	0.0113	0.0124
Schistosoma mansoni	amine GPCR	0.0023	0.0113	0.0124
Schistosoma mansoni	histamine h1 receptor	0.0023	0.0113	0.0124
Brugia malayi	Dopamine receptor protein 1	0.0023	0.0113	0.016
Brugia malayi	hypothetical protein	0.0023	0.0113	0.016
Echinococcus multilocularis	neuropeptide s receptor	0.0023	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Loa Loa (eye worm)	neuropeptide F receptor	0.0023	0.0113	0.016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0113	0.0124
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0023	0.0113	0.0124
Schistosoma mansoni	hypothetical protein	0.0018	0.005	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.055	0.0782
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0023	0.0113	0.0124
Trypanosoma brucei	DNA polymerase kappa, putative	0.0031	0.0209	0.0297
Echinococcus granulosus	serotonin receptor	0.0023	0.0113	0.0124
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0113	0.0124
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0334	0.0475
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0346	0.0381
Echinococcus granulosus	neuropeptides capa receptor	0.0023	0.0113	0.0124
Echinococcus granulosus	allatostatin A receptor	0.0023	0.0113	0.0124
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.005	0.0071
Echinococcus granulosus	neuropeptides capa receptor	0.0023	0.0113	0.0124
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0023	0.0113	0.0124
Onchocerca volvulus		0.003	0.0192	0.0298
Schistosoma mansoni	hypothetical protein	0.0023	0.0113	0.0124
Echinococcus granulosus	tar DNA binding protein	0.0074	0.0748	0.0822
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0023	0.0113	0.016
Schistosoma mansoni	hypothetical protein	0.0018	0.005	0.0055
Echinococcus multilocularis	GPCR, family 2	0.0018	0.005	0.005
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.017	0.1972	0.2804
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0113	0.0124
Schistosoma mansoni	amine GPCR	0.0023	0.0113	0.0124
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0113	0.0124
Echinococcus multilocularis	neuropeptide Y receptor	0.0023	0.0113	0.0113
Schistosoma mansoni	thyroid hormone receptor	0.0135	0.1526	0.1678
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.0113	0.0113
Brugia malayi	AKH receptor	0.0023	0.0113	0.016
Echinococcus granulosus	neuropeptide receptor	0.0023	0.0113	0.0124
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0023	0.0113	0.0113
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0023	0.0113	0.016
Brugia malayi	hypothetical protein	0.0023	0.0113	0.016
Brugia malayi	neuropeptide F receptor	0.0023	0.0113	0.016
Echinococcus granulosus	neuropeptide s receptor	0.0023	0.0113	0.0124
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.2426	0.3449
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.005	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0113	0.0124
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0113	0.0124
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0192	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0018	0.005	0.0071
Echinococcus multilocularis	survival motor neuron protein 1	0.0275	0.3289	0.3289
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0023	0.0113	0.016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0334	0.0475
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.005	0.005
Brugia malayi	TAR-binding protein	0.0074	0.0748	0.1064
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0023	0.0113	0.0124
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0023	0.0113	0.0113
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.005	0.005
Echinococcus granulosus	neuropeptide receptor A26	0.0023	0.0113	0.0124
Brugia malayi	hypothetical protein	0.0023	0.0113	0.016
Brugia malayi	neuropeptide F receptor	0.0023	0.0113	0.016
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0113	0.0113
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0571	0.7033	1
Schistosoma mansoni	thyroid hormone receptor	0.0135	0.1526	0.1678
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0113	0.0124
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0023	0.0113	0.0124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0113	0.0113
Schistosoma mansoni	hypothetical protein	0.0042	0.0346	0.0381
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.005	0.0055
Loa Loa (eye worm)	RNA binding protein	0.0074	0.0748	0.1064
Plasmodium vivax	SET domain protein, putative	0.003	0.0192	0.5
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0083	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0113	0.0124
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0023	0.0113	0.0124
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0125	0.1399	0.1538
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0023	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Trichomonas vaginalis	CMGC family protein kinase	0.0571	0.7033	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0571	0.7033	1
Giardia lamblia	Kinase, CMGC MAPK	0.0571	0.7033	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.0113	0.0113
Loa Loa (eye worm)	melatonin receptor type 1A	0.0023	0.0113	0.016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Brugia malayi	sulfakinin receptor protein	0.0023	0.0113	0.016
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.055	0.0782
Echinococcus granulosus	dro:myosuppressin receptor	0.0023	0.0113	0.0124
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0113	0.0124
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0748	0.0822
Schistosoma mansoni	amine GPCR	0.0023	0.0113	0.0124
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0026	0.0038
Onchocerca volvulus		0.0235	0.2786	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0023	0.0113	0.016
Brugia malayi	hypothetical protein	0.0023	0.0113	0.016
Brugia malayi	G-protein coupled receptor	0.0023	0.0113	0.016
Schistosoma mansoni	hypothetical protein	0.004	0.0318	0.035
Schistosoma mansoni	hypothetical protein	0.0056	0.0526	0.0579
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0125	0.1399	0.1399
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0334	0.0475
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0023	0.0113	0.016
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0571	0.7033	1
Schistosoma mansoni	amine GPCR	0.0023	0.0113	0.0124
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0334	0.0475
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0023	0.0113	0.0124
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0113	0.0124
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.004	0.0318	0.0453
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.017	0.1972	0.2804
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0135	0.1526	0.1526
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Brugia malayi	putative neuropeptide receptor NPR1	0.0023	0.0113	0.016
Brugia malayi	hypothetical protein	0.0023	0.0113	0.016
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0023	0.0113	0.0113
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0023	0.0113	0.0113
Trypanosoma brucei	DNA polymerase kappa, putative	0.0031	0.0209	0.0297
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0334	0.0475
Schistosoma mansoni	hypothetical protein	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.0334	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0113	0.0113
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0056	0.0526	0.0748
Schistosoma mansoni	adenoreceptor	0.0023	0.0113	0.0124
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0023	0.0113	0.0113
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.0113	0.0113
Brugia malayi	hypothetical protein	0.0023	0.0113	0.016
Brugia malayi	hypothetical protein	0.0023	0.0113	0.016
Brugia malayi	putative neuropeptide receptor	0.0023	0.0113	0.016
Brugia malayi	polk-prov protein	0.0031	0.0209	0.0297
Echinococcus granulosus	mitogen activated protein kinase 3	0.0571	0.7033	0.7733
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0113	0.0124
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0023	0.0113	0.016
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0334	0.0475
Echinococcus multilocularis	neuropeptide receptor	0.0023	0.0113	0.0113
Echinococcus multilocularis	neuropeptide receptor A26	0.0023	0.0113	0.0113
Echinococcus multilocularis	mitogen activated protein kinase	0.0571	0.7033	0.7033
Trypanosoma brucei	protein kinase, putative	0.0571	0.7033	1
Brugia malayi	hypothetical protein	0.0023	0.0113	0.016
Brugia malayi	RNA binding protein	0.0074	0.0748	0.1064
Echinococcus multilocularis	somatostatin receptor	0.0023	0.0113	0.0113
Echinococcus multilocularis	tar DNA binding protein	0.0074	0.0748	0.0748
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.0113	0.0124
Echinococcus multilocularis	neuropeptides capa receptor	0.0023	0.0113	0.0113
Echinococcus granulosus	sex peptide receptor	0.0023	0.0113	0.0124
Echinococcus multilocularis	fmrfamide receptor	0.0023	0.0113	0.0113
Echinococcus multilocularis	G protein coupled receptor 139	0.0023	0.0113	0.0113
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0334	0.0475
Brugia malayi	Serotonin receptor	0.0023	0.0113	0.016
Echinococcus granulosus	7tm_1 domain containing protein	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Trichomonas vaginalis	CMGC family protein kinase	0.0571	0.7033	1
Brugia malayi	hypothetical protein	0.0042	0.0346	0.0492
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.055	0.0782
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0023	0.0113	0.016
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.005	0.0071
Brugia malayi	GnHR receptor homolog	0.0023	0.0113	0.016
Echinococcus granulosus	survival motor neuron protein 1	0.0275	0.3289	0.3616
Echinococcus granulosus	biogenic amine 5HT receptor	0.0023	0.0113	0.0124
Echinococcus multilocularis	neuropeptide receptor	0.0023	0.0113	0.0113
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0748	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0083	0.0118
Brugia malayi	G-protein coupled receptor	0.0023	0.0113	0.016
Loa Loa (eye worm)	neuropeptide F receptor	0.0023	0.0113	0.016
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0748	0.0822
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0023	0.0113	0.0124
Schistosoma mansoni	hypothetical protein	0.0018	0.005	0.0055
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0023	0.0113	0.0124
Echinococcus multilocularis	orexin receptor type 2	0.0023	0.0113	0.0113
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0192	0.0192
Brugia malayi	RE15519p	0.0023	0.0113	0.016
Schistosoma mansoni	survival motor neuron protein	0.0056	0.0526	0.0579
Echinococcus granulosus	fmrfamide receptor	0.0023	0.0113	0.0124
Entamoeba histolytica	hypothetical protein	0.0042	0.0346	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus multilocularis	dro:myosuppressin receptor	0.0023	0.0113	0.0113
Loa Loa (eye worm)	G-protein coupled receptor	0.0023	0.0113	0.016
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0023	0.0113	0.016
Loa Loa (eye worm)	hypothetical protein	0.0275	0.3289	0.4676
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.0113	0.0124
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0023	0.0113	0.016
Schistosoma mansoni	growth hormone secretagogue receptor	0.0023	0.0113	0.0124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0113	0.0113
Echinococcus granulosus	biogenic amine 5HT receptor	0.017	0.1972	0.2168
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0179	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Schistosoma mansoni	neuropeptide f receptor 76f	0.0023	0.0113	0.0124
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Brugia malayi	Pre-SET motif family protein	0.003	0.0192	0.0273
Echinococcus granulosus	neuropeptide receptor	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0113	0.0124
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0571	0.7033	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0113	0.0124
Schistosoma mansoni	opsin-like receptor	0.0023	0.0113	0.0124
Brugia malayi	follicle stimulating hormone receptor	0.0023	0.0113	0.016
Echinococcus multilocularis	fmrfamide receptor	0.0023	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0734	0.9095	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0023	0.0113	0.0124
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0023	0.0113	0.0124
Echinococcus granulosus	g protein coupled receptor	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0571	0.7033	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0192	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Brugia malayi	Pre-SET motif family protein	0.0206	0.2426	0.3449
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Schistosoma mansoni	hypothetical protein	0.0023	0.0113	0.0124
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0113	0.0124
Schistosoma mansoni	amine GPCR	0.0023	0.0113	0.0124
Schistosoma mansoni	hypothetical protein	0.0023	0.0113	0.0124
Echinococcus granulosus	orexin receptor type 2	0.0023	0.0113	0.0124
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0192	0.0211
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0334	0.0475
Trypanosoma brucei	DNA polymerase IV, putative	0.0034	0.0251	0.0357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0113	0.0124
Brugia malayi	ORL1-like opioid receptor	0.0023	0.0113	0.016
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.0113	0.0113
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus granulosus	dna polymerase kappa	0.0041	0.0334	0.0367
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0023	0.0113	0.0113
Schistosoma mansoni	serine/threonine protein kinase	0.0571	0.7033	0.7733
Brugia malayi	hypothetical protein	0.0275	0.3289	0.4676
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0571	0.7033	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0113	0.0124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0023	0.0113	0.016
Schistosoma mansoni	neuropeptide F-like receptor	0.0023	0.0113	0.0124
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0571	0.7033	1
Entamoeba histolytica	hypothetical protein	0.0042	0.0346	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0023	0.0113	0.0113
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0074	0.0748	0.1064
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0113	0.0124
Echinococcus granulosus	mitogen activated protein kinase	0.0571	0.7033	0.7733
Echinococcus granulosus	neuropeptide FF receptor 2	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0023	0.0113	0.0124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0113	0.0113
Echinococcus multilocularis	neuropeptides capa receptor	0.0023	0.0113	0.0113
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0023	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus multilocularis	neuropeptide Y receptor	0.0023	0.0113	0.0113
Entamoeba histolytica	hypothetical protein	0.0042	0.0346	1
Echinococcus multilocularis	g-protein coupled receptor	0.0023	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0023	0.0113	0.0113
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0734	0.9095	1
Schistosoma mansoni	opsin-like receptor	0.0023	0.0113	0.0124
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0318	0.0453
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.0334	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0023	0.0113	0.0124
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0083	0.0118
Brugia malayi	hypothetical protein	0.0023	0.0113	0.016
Schistosoma mansoni	biogenic amine (5HT) receptor	0.017	0.1972	0.2168
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Echinococcus multilocularis	serotonin receptor	0.017	0.1972	0.1972
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0113	0.0124
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0192	0.0211
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0113	0.0124
Echinococcus granulosus	G protein coupled receptor 139	0.0023	0.0113	0.0124
Trichomonas vaginalis	set domain proteins, putative	0.0235	0.2786	0.3661
Echinococcus granulosus	7TM GPCR rhodopsin	0.0023	0.0113	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0113	0.016
Brugia malayi	Dopamine receptor protein 2	0.0023	0.0113	0.016
Echinococcus multilocularis	dna polymerase kappa	0.0041	0.0334	0.0334
Onchocerca volvulus		0.0056	0.0526	0.1547
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0334	0.0475
Brugia malayi	G protein-coupled receptor	0.0023	0.0113	0.016

Activities

Activity type	Activity value	Assay description	Source	Reference
Efficacy (functional)	= 20 %	Percent inhibition of vasoactive intestinal polypeptide-induced (VIP-induced) cAMP formation in GH4ZD10 cells expressing 5-HT1A receptor at 50 uM relative to 5-HT	ChEMBL.	10956192
Ki (binding)	= 397 nM	In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membranes	ChEMBL.	10956192
Ki (binding)	> 1000 nM	In vitro binding affinity at 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat cortex	ChEMBL.	10956192
Ki (binding)	> 1000 nM	In vitro binding affinity at human cloned Dopamine receptor D2A measured by ability to displace [3H]-raclopride from D2A receptor expressed in mouse fibroblast (LtK-) cells	ChEMBL.	10956192
Ki (binding)	> 1000 nM	In vitro binding affinity at D1 receptor by measuring its ability to displace [3H]-SCH-23,390 from Dopamine receptor D1 in rat striatum	ChEMBL.	10956192

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 257884

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 159934