Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.025 | 0.3039 | 0.4607 |
Brugia malayi | Protein kinase domain containing protein | 0.025 | 0.3039 | 0.3039 |
Trichomonas vaginalis | AGC family protein kinase | 0.075 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0282 | 0.3492 | 0.5294 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0086 | 0.0762 | 0.0762 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.025 | 0.3039 | 0.4607 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0086 | 0.0762 | 0.0762 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.025 | 0.3039 | 0.4607 |
Brugia malayi | Hr1 repeat family protein | 0.025 | 0.3039 | 0.3039 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0479 | 0.6234 | 0.9452 |
Schistosoma mansoni | serine/threonine kinase | 0.025 | 0.3039 | 0.4607 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0077 | 0.0628 | 0.0952 |
Echinococcus granulosus | proteasome prosome macropain | 0.0077 | 0.0628 | 0.0952 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.025 | 0.3039 | 0.3039 |
Entamoeba histolytica | protein kinase, putative | 0.075 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.075 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.075 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.075 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.075 | 1 | 1 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0055 | 0.0321 | 0.0321 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0479 | 0.6234 | 0.9452 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0077 | 0.0628 | 0.0952 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0505 | 0.6595 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0077 | 0.0628 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.025 | 0.3039 | 0.2572 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0245 | 0.2963 | 0.2492 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0164 | 0.1847 | 0.1847 |
Brugia malayi | protein kinase C II. | 0.025 | 0.3039 | 0.3039 |
Echinococcus granulosus | protein kinase c epsilon type | 0.025 | 0.3039 | 0.4607 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0077 | 0.0628 | 0.0628 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0077 | 0.0628 | 0.0628 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0321 | 0.0486 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0077 | 0.0628 | 0.0952 |
Echinococcus granulosus | protein kinase C gamma type | 0.025 | 0.3039 | 0.4607 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0086 | 0.0762 | 0.0762 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0485 | 0.6309 | 0.9566 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0485 | 0.6309 | 0.9566 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.025 | 0.3039 | 0.3039 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0077 | 0.0628 | 0.5 |
Echinococcus multilocularis | nervana 2 | 0.0479 | 0.6234 | 0.9452 |
Echinococcus multilocularis | nervana 2 | 0.0479 | 0.6234 | 0.9452 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0505 | 0.6595 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0305 | 0.3812 | 0.3812 |
Trichomonas vaginalis | AGC family protein kinase | 0.075 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Echinococcus granulosus | NDR protein kinase | 0.025 | 0.3039 | 0.4607 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.025 | 0.3039 | 0.4607 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0505 | 0.6595 | 0.6595 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0077 | 0.0628 | 0.0628 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.025 | 0.3039 | 0.4607 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0505 | 0.6595 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0505 | 0.6595 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.025 | 0.3039 | 0.4607 |
Echinococcus granulosus | nervana 2 | 0.0479 | 0.6234 | 0.9452 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0077 | 0.0628 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0337 | 0.4254 | 0.4254 |
Echinococcus multilocularis | serine threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0383 | 0.4897 | 0.7426 |
Schistosoma mansoni | atypical protein kinase C | 0.025 | 0.3039 | 0.4607 |
Trichomonas vaginalis | AGC family protein kinase | 0.075 | 1 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0485 | 0.6309 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0762 | 0.0762 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.075 | 1 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0485 | 0.6309 | 0.9566 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0729 | 0.9714 | 0.9714 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0055 | 0.0321 | 0.0486 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.025 | 0.3039 | 0.4607 |
Entamoeba histolytica | protein kinase, putative | 0.0729 | 0.9714 | 0.9714 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0505 | 0.6595 | 0.6595 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.025 | 0.3039 | 0.4607 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.3039 | 0.3039 |
Echinococcus multilocularis | protein kinase c iota type | 0.025 | 0.3039 | 0.4607 |
Loa Loa (eye worm) | glutamate receptor | 0.0337 | 0.4254 | 0.4254 |
Brugia malayi | Protein kinase domain containing protein | 0.025 | 0.3039 | 0.3039 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0077 | 0.0628 | 0.0952 |
Loa Loa (eye worm) | glutamate receptor | 0.0133 | 0.1406 | 0.1406 |
Trichomonas vaginalis | AGC family protein kinase | 0.075 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.025 | 0.3039 | 0.2572 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0479 | 0.6234 | 0.9452 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0077 | 0.0628 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0415 | 0.5339 | 0.5339 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0055 | 0.0321 | 0.0486 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.025 | 0.3039 | 0.3039 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.025 | 0.3039 | 0.4607 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.025 | 0.3039 | 0.4607 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.075 | 1 | 1 |
Trypanosoma cruzi | Protein kinase B | 0.0505 | 0.6595 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0282 | 0.3492 | 0.5294 |
Echinococcus granulosus | nervana 2 | 0.0479 | 0.6234 | 0.9452 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0729 | 0.9714 | 0.9714 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0485 | 0.6309 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0415 | 0.5339 | 0.8095 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Trichomonas vaginalis | AGC family protein kinase | 0.027 | 0.3325 | 0.2878 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0485 | 0.6309 | 0.9566 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0415 | 0.5339 | 0.8095 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.025 | 0.3039 | 0.3039 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0321 | 0.0321 |
Entamoeba histolytica | protein kinase, putative | 0.025 | 0.3039 | 0.3039 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.025 | 0.3039 | 0.4607 |
Toxoplasma gondii | AGC kinase | 0.0729 | 0.9714 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.025 | 0.3039 | 0.3039 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0164 | 0.1847 | 0.2801 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0055 | 0.0321 | 1 |
Entamoeba histolytica | protein kinase 2, putative | 0.0485 | 0.6309 | 0.6309 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.025 | 0.3039 | 0.3039 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0282 | 0.3492 | 0.5294 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0055 | 0.0321 | 1 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0479 | 0.6234 | 0.9452 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.025 | 0.3039 | 0.4607 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.025 | 0.3039 | 0.4607 |
Echinococcus granulosus | protein kinase c iota type | 0.025 | 0.3039 | 0.4607 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0505 | 0.6595 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.025 | 0.3039 | 0.2572 |
Giardia lamblia | Kinase, AGC PKA | 0.0485 | 0.6309 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC80 (functional) | = 0.25 ug ml-1 | Antifungal activity against Candida albicans after 24 hrs by serial dilution method | ChEMBL. | 22348827 |
MIC80 (functional) | = 32 ug ml-1 | Antifungal activity against Cryptococcus neoformans after 72 hrs by serial dilution method | ChEMBL. | 22348827 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.