Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.027 | 0.3325 | 0.2878 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0077 | 0.0628 | 0.0952 |
Echinococcus multilocularis | serine threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0479 | 0.6234 | 0.9452 |
Echinococcus granulosus | protein kinase c iota type | 0.025 | 0.3039 | 0.4607 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0729 | 0.9714 | 0.9714 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0485 | 0.6309 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0164 | 0.1847 | 0.2801 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0282 | 0.3492 | 0.5294 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.025 | 0.3039 | 0.4607 |
Loa Loa (eye worm) | hypothetical protein | 0.0415 | 0.5339 | 0.5339 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.075 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0321 | 0.0486 |
Schistosoma mansoni | serine/threonine kinase | 0.025 | 0.3039 | 0.4607 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.025 | 0.3039 | 0.4607 |
Echinococcus granulosus | protein kinase C gamma type | 0.025 | 0.3039 | 0.4607 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0077 | 0.0628 | 0.5 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0485 | 0.6309 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0086 | 0.0762 | 0.0762 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.025 | 0.3039 | 0.3039 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0485 | 0.6309 | 0.9566 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0729 | 0.9714 | 0.9714 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0086 | 0.0762 | 0.0762 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0055 | 0.0321 | 0.0321 |
Brugia malayi | Protein kinase domain containing protein | 0.025 | 0.3039 | 0.3039 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0305 | 0.3812 | 0.3812 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0055 | 0.0321 | 1 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.025 | 0.3039 | 0.4607 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0762 | 0.0762 |
Echinococcus granulosus | nervana 2 | 0.0479 | 0.6234 | 0.9452 |
Trichomonas vaginalis | AGC family protein kinase | 0.075 | 1 | 1 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.025 | 0.3039 | 0.4607 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0077 | 0.0628 | 0.0628 |
Echinococcus multilocularis | nervana 2 | 0.0479 | 0.6234 | 0.9452 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0164 | 0.1847 | 0.1847 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0282 | 0.3492 | 0.5294 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.3039 | 0.3039 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.025 | 0.3039 | 0.4607 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.025 | 0.3039 | 0.4607 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.075 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0282 | 0.3492 | 0.5294 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.025 | 0.3039 | 0.3039 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.025 | 0.3039 | 0.3039 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0505 | 0.6595 | 0.6595 |
Loa Loa (eye worm) | glutamate receptor | 0.0337 | 0.4254 | 0.4254 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0505 | 0.6595 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.075 | 1 | 1 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.025 | 0.3039 | 0.3039 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.025 | 0.3039 | 0.4607 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Echinococcus granulosus | NDR protein kinase | 0.025 | 0.3039 | 0.4607 |
Trichomonas vaginalis | AGC family protein kinase | 0.075 | 1 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0479 | 0.6234 | 0.9452 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.025 | 0.3039 | 0.4607 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0077 | 0.0628 | 0.0952 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0479 | 0.6234 | 0.9452 |
Trichomonas vaginalis | AGC family protein kinase | 0.025 | 0.3039 | 0.2572 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.025 | 0.3039 | 0.4607 |
Trypanosoma cruzi | Protein kinase B | 0.0505 | 0.6595 | 1 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0055 | 0.0321 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0485 | 0.6309 | 0.9566 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0077 | 0.0628 | 0.5 |
Brugia malayi | Hr1 repeat family protein | 0.025 | 0.3039 | 0.3039 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0485 | 0.6309 | 0.9566 |
Echinococcus multilocularis | protein kinase c iota type | 0.025 | 0.3039 | 0.4607 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.025 | 0.3039 | 0.3039 |
Trichomonas vaginalis | AGC family protein kinase | 0.075 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.075 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0415 | 0.5339 | 0.8095 |
Entamoeba histolytica | protein kinase, putative | 0.025 | 0.3039 | 0.3039 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0505 | 0.6595 | 1 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.025 | 0.3039 | 0.4607 |
Schistosoma mansoni | atypical protein kinase C | 0.025 | 0.3039 | 0.4607 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0485 | 0.6309 | 0.9566 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0077 | 0.0628 | 0.0952 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0505 | 0.6595 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0077 | 0.0628 | 0.0952 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0086 | 0.0762 | 0.0762 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.025 | 0.3039 | 0.4607 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0077 | 0.0628 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.025 | 0.3039 | 0.3039 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0505 | 0.6595 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.025 | 0.3039 | 0.4607 |
Brugia malayi | Protein kinase domain containing protein | 0.025 | 0.3039 | 0.3039 |
Entamoeba histolytica | protein kinase, putative | 0.0729 | 0.9714 | 0.9714 |
Echinococcus granulosus | proteasome prosome macropain | 0.0077 | 0.0628 | 0.0952 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0415 | 0.5339 | 0.8095 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0055 | 0.0321 | 0.0486 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0505 | 0.6595 | 0.6595 |
Giardia lamblia | Kinase, AGC PKA | 0.0485 | 0.6309 | 1 |
Entamoeba histolytica | protein kinase 2, putative | 0.0485 | 0.6309 | 0.6309 |
Echinococcus granulosus | nervana 2 | 0.0479 | 0.6234 | 0.9452 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Entamoeba histolytica | protein kinase, putative | 0.075 | 1 | 1 |
Toxoplasma gondii | AGC kinase | 0.0729 | 0.9714 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0383 | 0.4897 | 0.7426 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0077 | 0.0628 | 0.0628 |
Echinococcus granulosus | protein kinase c epsilon type | 0.025 | 0.3039 | 0.4607 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0479 | 0.6234 | 0.9452 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.025 | 0.3039 | 0.4607 |
Mycobacterium ulcerans | proteasome PrcB | 0.0077 | 0.0628 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.025 | 0.3039 | 0.2572 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0337 | 0.4254 | 0.4254 |
Echinococcus multilocularis | nervana 2 | 0.0479 | 0.6234 | 0.9452 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0505 | 0.6595 | 1 |
Brugia malayi | protein kinase C II. | 0.025 | 0.3039 | 0.3039 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0077 | 0.0628 | 0.0628 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0321 | 0.0321 |
Trichomonas vaginalis | AGC family protein kinase | 0.075 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0133 | 0.1406 | 0.1406 |
Trichomonas vaginalis | AGC family protein kinase | 0.075 | 1 | 1 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0245 | 0.2963 | 0.2492 |
Trichomonas vaginalis | AGC family protein kinase | 0.025 | 0.3039 | 0.2572 |
Trichomonas vaginalis | AGC family protein kinase | 0.075 | 1 | 1 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0055 | 0.0321 | 0.0486 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.3039 | 0.4607 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC80 (functional) | = 0.5 ug ml-1 | Antifungal activity against Candida albicans after 24 hrs by serial dilution method | ChEMBL. | 22348827 |
MIC80 (functional) | = 32 ug ml-1 | Antifungal activity against Cryptococcus neoformans after 72 hrs by serial dilution method | ChEMBL. | 22348827 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.