Detailed information for compound 160051

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 219.089 | Formula: C6H6NO6P--
  • H donors: 3 H acceptors: 6 LogP: -1.62 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]C(=O)c1[nH]cc(c1)C(P(=O)(O)[O-])O
  • InChi: 1S/C6H8NO6P/c8-5(9)4-1-3(2-7-4)6(10)14(11,12)13/h1-2,6-7,10H,(H,8,9)(H2,11,12,13)/p-2
  • InChiKey: FUIBIIXRDPUFOF-UHFFFAOYSA-L  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0098 0.2299 0.2297
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0173 0.017
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Schistosoma mansoni cell adhesion molecule 0.0038 0.0768 0.0746
Trichomonas vaginalis glutaminase, putative 0.0264 0.6611 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0774 0.0805
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0973 0.097
Echinococcus multilocularis neuroglian 0.004 0.0805 0.0803
Schistosoma mansoni nephrin 0.004 0.0805 0.0783
Schistosoma mansoni hypothetical protein 0.0075 0.1707 0.1688
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0173 0.017
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0032 0.0597 0.0575
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0015 0.016 0.0157
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.001 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0198
Schistosoma mansoni DNA helicase recq1 0.0019 0.0276 0.0253
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0263 0.026
Loa Loa (eye worm) MBCTL1 0.0053 0.1138 0.132
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0263 0.026
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0263 0.0306
Loa Loa (eye worm) hypothetical protein 0.0109 0.2599 0.3021
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0038 0.0768 0.0765
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0673 0.067
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0098 0.2299 0.2297
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0774 1
Echinococcus granulosus phd:f box containing protein 0.0015 0.0173 0.017
Echinococcus granulosus dna polymerase kappa 0.0019 0.0263 0.026
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.143 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.016 0.0183
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.143 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0276 0.0321
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0173 0.0149
Echinococcus granulosus hemicentin 1 0.0015 0.016 0.0157
Schistosoma mansoni nephrin 0.0015 0.016 0.0137
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0735 0.0733
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.143 0.1663
Loa Loa (eye worm) hypothetical protein 0.0032 0.0597 0.0691
Loa Loa (eye worm) hypothetical protein 0.0019 0.0276 0.0318
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.143 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Schistosoma mansoni tyrosine kinase 0.0098 0.2299 0.2281
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0973 0.097
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0973 0.0951
Loa Loa (eye worm) hypothetical protein 0.0075 0.1707 0.1983
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.2599 0.3021
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0173 0.017
Echinococcus multilocularis roundabout 2 0.0015 0.016 0.0157
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0276 0.1718
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0173 0.0198
Plasmodium vivax JmjC domain containing protein 0.0015 0.0173 0.1986
Schistosoma mansoni DNA helicase recq5 0.0019 0.0276 0.0253
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0357 0.9002 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Loa Loa (eye worm) hypothetical protein 0.0032 0.0597 0.0691
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0173 0.0198
Loa Loa (eye worm) hypothetical protein 0.0046 0.0976 0.1133
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0597 0.0694
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.1707 0.1986
Schistosoma mansoni hypothetical protein 0.0035 0.0673 0.065
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0774 0.5019
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0263 0.1136
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0276 0.002
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0033 0.0011
Schistosoma mansoni cpg binding protein 0.0028 0.0498 0.0476
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0341 0.8597 1
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0173 0.0149
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.143 0.141
Loa Loa (eye worm) hypothetical protein 0.0035 0.0673 0.0779
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0198
Schistosoma mansoni hypothetical protein 0.0035 0.0673 0.065
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0263 0.1645
Schistosoma mansoni hypothetical protein 0.0035 0.0673 0.065
Schistosoma mansoni cell adhesion molecule 0.0015 0.016 0.0137
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0774 0.0772
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0218 0.5413 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.1138 0.132
Schistosoma mansoni ap endonuclease 0.0038 0.0774 0.0752
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0173 0.017
Echinococcus granulosus peroxidasin 0.0015 0.016 0.0157
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0214 0.0211
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0173 0.0149
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0263 0.1645
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.4678 0.4676
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0276 0.002
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0173 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Echinococcus granulosus neuroglian 0.0015 0.016 0.0157
Echinococcus granulosus tyrosine protein kinase otk 0.0015 0.016 0.0157
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.1291 0.1289
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0218 0.5413 0.3627
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0276 0.1794
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.2599 0.3023
Schistosoma mansoni roundabout 0.0015 0.016 0.0137
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0774 1
Schistosoma mansoni septate junction protein 0.0015 0.016 0.0137
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0263 0.1702
Loa Loa (eye worm) hypothetical protein 0.0032 0.0597 0.0691
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0673 0.067
Loa Loa (eye worm) glutaminase 0.0264 0.6611 0.7689
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0673 0.0782
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.125 0.1248
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0276 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0263 0.0718
Echinococcus granulosus GPCR family 2 0.0035 0.0673 0.067
Echinococcus multilocularis cpg binding protein 0.0029 0.0539 0.0537
Brugia malayi hypothetical protein 0.0032 0.0597 0.0694
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Echinococcus granulosus lachesin 0.0015 0.016 0.0157
Loa Loa (eye worm) glutaminase 2 0.0264 0.6611 0.7689
Loa Loa (eye worm) hypothetical protein 0.0032 0.0597 0.0691
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0263 0.0306
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0774 0.0901
Loa Loa (eye worm) hypothetical protein 0.0032 0.0597 0.0691
Brugia malayi Prion-like- 0.0015 0.016 0.0186
Brugia malayi jmjC domain containing protein 0.0015 0.0173 0.0201
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0276 0.1718
Echinococcus multilocularis neuroglian 0.0015 0.016 0.0157
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0774 0.1645
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0673 0.0779
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0173 0.0198
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0276 0.002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1291 0.1271
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0276 0.0273
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0263 0.1136
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0015 0.016 0.0157
Leishmania major DNA polymerase eta, putative 0.0019 0.0263 0.0718
Loa Loa (eye worm) hypothetical protein 0.0019 0.0263 0.0303
Leishmania major DNA polymerase kappa, putative 0.0019 0.0263 0.0718
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1303 0.1282
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.016 0.0183
Brugia malayi Fibronectin type III domain containing protein 0.0032 0.0597 0.0694
Echinococcus granulosus fibroblast growth factor receptor 4 0.0098 0.2299 0.2297
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.143 0.1428
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0173 0.017
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.143 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0774 0.4784
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0276 0.1235
Brugia malayi jmjC domain containing protein 0.0015 0.0173 0.0201
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0357 0.9002 1
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0173 0.017
Echinococcus granulosus Immunoglobulin 0.0032 0.0597 0.0594
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0774 0.5337
Onchocerca volvulus 0.0301 0.7562 0.9666
Echinococcus multilocularis hemicentin 1 0.0015 0.016 0.0157
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0263 0.024
Loa Loa (eye worm) TK/ROR protein kinase 0.001 0.0037 0.004
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.1138 0.1117
Brugia malayi jmjC domain containing protein 0.0015 0.0173 0.0201
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0774 0.0898
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.001 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0015 0.016 0.0157
Brugia malayi CXXC zinc finger family protein 0.0028 0.0498 0.058
Echinococcus granulosus cpg binding protein 0.0029 0.0539 0.0537
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Schistosoma mansoni vesicular amine transporter 0.0032 0.0597 0.0575
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0973 0.0951
Toxoplasma gondii exonuclease III APE 0.0038 0.0774 0.0836
Loa Loa (eye worm) TK protein kinase 0.0106 0.2507 0.2914
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0015 0.016 0.0157
Loa Loa (eye worm) hypothetical protein 0.0038 0.0768 0.089
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0218 0.5413 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0973 0.1128
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0357 0.9002 1
Trypanosoma brucei unspecified product 0.0019 0.0263 0.1136
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0035
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0173 0.0998
Schistosoma mansoni hypothetical protein 0.0288 0.7226 0.7219
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0276 0.0822
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0673 0.067
Schistosoma mansoni septate junction protein 0.0015 0.016 0.0137
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0276 0.0273
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0774 0.0805
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0032 0.0597 0.0575
Brugia malayi jmjC domain containing protein 0.0058 0.1291 0.1502
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0015 0.016 0.0183
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.016 0.0183
Schistosoma mansoni ap endonuclease 0.0038 0.0774 0.0752
Echinococcus multilocularis roundabout 2 0.0046 0.0976 0.0974
Schistosoma mansoni hypothetical protein 0.0396 1 1
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0973 0.097
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0032 0.0597 0.0594
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.1291 0.1499
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0276 0.0281
Brugia malayi Peroxidasin 0.0015 0.016 0.0186
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.143 0.1661
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0774 0.5305
Schistosoma mansoni neuroglian 0.0015 0.016 0.0137
Echinococcus multilocularis Immunoglobulin 0.0032 0.0597 0.0594
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0263 0.0303
Schistosoma mansoni hypothetical protein 0.0035 0.0673 0.065
Schistosoma mansoni 3-dehydroquinate synthase 0.0139 0.337 0.3355
Onchocerca volvulus Tyrosine kinase homolog 0.0311 0.7818 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0173 0.0998
Echinococcus multilocularis tyrosine protein kinase otk 0.0015 0.016 0.0157
Schistosoma mansoni cell adhesion molecule 0.0015 0.016 0.0137
Echinococcus granulosus neuroglian 0.004 0.0805 0.0803
Mycobacterium ulcerans glutaminase 0.0264 0.6611 0.7263
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0015 0.016 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Echinococcus granulosus dna polymerase eta 0.0019 0.0263 0.026
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0357 0.9002 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0098 0.2299 0.2297
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0139 0.337 0.3556
Echinococcus granulosus roundabout 2 0.0046 0.0976 0.0974
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0276 0.0273
Brugia malayi mbt repeat family protein 0.0046 0.0973 0.1131
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0015 0.016 0.0157
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.1138 0.1323
Schistosoma mansoni cpg binding protein 0.0029 0.0539 0.0517
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0263 0.1645
Schistosoma mansoni tyrosine kinase 0.0017 0.0208 0.0185
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0173 0.0451
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0263 0.026
Brugia malayi Immunoglobulin I-set domain containing protein 0.0106 0.2507 0.2916
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0735 0.0733
Echinococcus multilocularis peroxidasin 0.0015 0.016 0.0157
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0276 0.0281
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0015 0.016 0.0137
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0033 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.143 0.1428
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.4678 0.4676
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.1138 0.1135
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0498 0.0577
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0973 0.1061
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.1138 0.1135
Loa Loa (eye worm) hypothetical protein 0.0032 0.0597 0.0691
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0276 0.0273
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0173 0.0166
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0263 0.1645
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0774 0.5305
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0774 0.0772
Schistosoma mansoni cpg binding protein 0.0029 0.0539 0.0517
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0033 0.001
Echinococcus granulosus defective proboscis extension response 0.0032 0.0597 0.0594
Echinococcus granulosus twitchin 0.004 0.0805 0.0803
Echinococcus granulosus bloom syndrome protein 0.0019 0.0276 0.0273
Brugia malayi jmjC domain containing protein 0.0015 0.0173 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0035
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0263 0.1136
Schistosoma mansoni jumonji domain containing protein 0.0057 0.125 0.123
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0276 0.0254
Echinococcus multilocularis lachesin 0.0015 0.016 0.0157
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0263 0.1136
Schistosoma mansoni glutaminase 0.0264 0.6611 0.6603
Loa Loa (eye worm) RecQ helicase 0.0019 0.0276 0.0318
Echinococcus granulosus roundabout 2 0.0015 0.016 0.0157
Echinococcus multilocularis roundabout 2 0.0015 0.016 0.0157
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.125 0.1248
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Brugia malayi mbt repeat family protein 0.0046 0.0973 0.1131
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.125 0.1248
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0774 0.0585
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0973 0.097
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0774 0.1377
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0218 0.5413 0.5893
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.1138 0.1135
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0173 0.0149
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0015 0.016 0.0137
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.143 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Echinococcus multilocularis dna polymerase eta 0.0019 0.0263 0.026
Brugia malayi jmjC domain containing protein 0.0057 0.125 0.1454
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0263 0.024
Schistosoma mansoni cell adhesion molecule 0.0015 0.016 0.0137
Entamoeba histolytica recQ family DNA helicase 0.001 0.0033 0.0068
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0276 0.0321
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0173 0.0149
Loa Loa (eye worm) hypothetical protein 0.0046 0.0976 0.1133
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0263 0.1645
Brugia malayi glutaminase DH11.1 0.0264 0.6611 0.7689
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0673 0.067
Echinococcus multilocularis GPCR, family 2 0.0035 0.0673 0.067
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0139 0.337 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0276 0.0273
Onchocerca volvulus 0.0046 0.0973 0.1061
Echinococcus granulosus roundabout 2 0.0015 0.016 0.0157
Brugia malayi Immunoglobulin I-set domain containing protein 0.0341 0.8597 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0214 0.0211
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0139 0.337 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0173 0.0166
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0973 0.1128
Schistosoma mansoni DNA polymerase eta 0.0019 0.0263 0.024
Echinococcus granulosus contactin 0.0015 0.016 0.0157
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0276 0.0318
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0673 0.0782
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0973 0.0951
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.114 0.1244
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.1138 0.1135
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0774 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.2599 0.3023
Echinococcus multilocularis Immunoglobulin 0.0032 0.0597 0.0594
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0276 0.1738
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Echinococcus multilocularis hemicentin 1 0.0015 0.016 0.0157
Onchocerca volvulus 0.0028 0.0498 0.0441
Echinococcus multilocularis dnaJ subfamily B 0.0396 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1291 0.1271
Schistosoma mansoni titin 0.0015 0.016 0.0137
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0198

Activities

Activity type Activity value Assay description Source Reference
Ki app (binding) = 14.5 nM Compound was tested for inhibitory activity against EPSP(5-enolpyruvylshikimate 3-phosphate) synthase in E. coli. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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