TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 219.089 | Formula: C6H6NO6P--
H donors: 3 H acceptors: 6 LogP: -1.62 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: [O-]C(=O)c1[nH]cc(c1)C(P(=O)(O)[O-])O
InChi: 1S/C6H8NO6P/c8-5(9)4-1-3(2-7-4)6(10)14(11,12)13/h1-2,6-7,10H,(H,8,9)(H2,11,12,13)/p-2
InChiKey: FUIBIIXRDPUFOF-UHFFFAOYSA-L

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0276	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1707	0.1983
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0263	0.1136
Schistosoma mansoni	phd/f-box containing protein	0.0015	0.0173	0.0149
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0033	0.001
Schistosoma mansoni	phosphatidylserine receptor	0.0015	0.0173	0.0149
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.001	0.0037	0.0034
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0774	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0673	0.067
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.143	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.016	0.0157
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0098	0.2299	0.2297
Echinococcus multilocularis	hemicentin 1	0.0015	0.016	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0673	0.067
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0774	0.0772
Echinococcus multilocularis	lachesin	0.0015	0.016	0.0157
Loa Loa (eye worm)	TK/ROR protein kinase	0.001	0.0037	0.004
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.1138	0.1135
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0973	0.0951
Brugia malayi	jmjC domain containing protein	0.0015	0.0173	0.0201
Schistosoma mansoni	ap endonuclease	0.0038	0.0774	0.0752
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0032	0.0597	0.0575
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0263	0.1645
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0173	0.0998
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.001	0.0037	0.0034
Echinococcus multilocularis	lysine specific demethylase 5A	0.0057	0.125	0.1248
Schistosoma mansoni	DNA helicase recq5	0.0019	0.0276	0.0253
Brugia malayi	Fibronectin type III domain containing protein	0.0032	0.0597	0.0694
Schistosoma mansoni	septate junction protein	0.0015	0.016	0.0137
Echinococcus multilocularis	Immunoglobulin	0.0032	0.0597	0.0594
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0019	0.0276	0.0273
Schistosoma mansoni	nephrin	0.0015	0.016	0.0137
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0263	0.024
Mycobacterium ulcerans	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0218	0.5413	0.5893
Mycobacterium leprae	probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS	0.0357	0.9002	1
Mycobacterium ulcerans	glutaminase	0.0264	0.6611	0.7263
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0263	0.1645
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0064	0.143	0.1428
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0263	0.024
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0673	0.067
Schistosoma mansoni	vesicular amine transporter	0.0032	0.0597	0.0575
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0015	0.016	0.0137
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.125	0.123
Loa Loa (eye worm)	glutaminase 2	0.0264	0.6611	0.7689
Schistosoma mansoni	cell adhesion molecule	0.0015	0.016	0.0137
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0263	0.0306
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0015	0.0173	0.0149
Schistosoma mansoni	hypothetical protein	0.0075	0.1707	0.1688
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.1138	0.1135
Onchocerca volvulus		0.0028	0.0498	0.0441
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Echinococcus multilocularis	hemicentin 1	0.0015	0.016	0.0157
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0774	0.0805
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.1291	0.1499
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0774	0.0901
Schistosoma mansoni	cell adhesion molecule	0.0015	0.016	0.0137
Mycobacterium ulcerans	3-dehydroquinate synthase	0.0139	0.337	0.3556
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0019	0.0276	0.0273
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0263	0.024
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.1291	0.1271
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0173	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0976	0.1133
Schistosoma mansoni	cell adhesion molecule	0.0015	0.016	0.0137
Echinococcus multilocularis	cpg binding protein	0.0029	0.0539	0.0537
Echinococcus multilocularis	peroxidasin	0.0015	0.016	0.0157
Schistosoma mansoni	titin	0.0015	0.016	0.0137
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0276	0.0281
Echinococcus granulosus	lysine specific demethylase 6a	0.0015	0.0173	0.017
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0106	0.2507	0.2916
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0038	0.0774	0.1377
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0263	0.026
Echinococcus granulosus	defective proboscis extension response	0.0032	0.0597	0.0594
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0263	0.1702
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.0774	0.5305
Schistosoma mansoni	hypothetical protein	0.0035	0.0673	0.065
Echinococcus multilocularis	roundabout 2	0.0046	0.0976	0.0974
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0173	0.0198
Echinococcus granulosus	jumonji domain containing 1A	0.0015	0.0173	0.017
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.0774	0.1645
Brugia malayi	Prion-like-	0.0015	0.016	0.0186
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0046	0.0973	0.097
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0673	0.0779
Brugia malayi	jmjC domain containing protein	0.0058	0.1291	0.1502
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0276	0.0321
Echinococcus granulosus	lysine specific demethylase 5A	0.0058	0.1291	0.1289
Echinococcus granulosus	JmjC domain containing protein 4	0.0015	0.0173	0.017
Echinococcus granulosus	phd:f box containing protein	0.0015	0.0173	0.017
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1138	0.132
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.143	1
Brugia malayi	Peroxidasin	0.0015	0.016	0.0186
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0038	0.0774	1
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0973	0.0951
Onchocerca volvulus		0.0301	0.7562	0.9666
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0064	0.143	0.141
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.016	0.0183
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0033	0.0011
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Schistosoma mansoni	cpg binding protein	0.0029	0.0539	0.0517
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0498	0.0577
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0774	0.0805
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0341	0.8597	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.0597	0.0694
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0173	0.0198
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Schistosoma mansoni	protein phosphatase 2C	0.0015	0.0173	0.0149
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Mycobacterium tuberculosis	3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS)	0.0139	0.337	1
Schistosoma mansoni	neuroglian	0.0015	0.016	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0173	0.0198
Trichomonas vaginalis	DNA helicase recq1, putative	0.0019	0.0276	0.002
Schistosoma mansoni	jumonji domain containing protein	0.0015	0.0173	0.0149
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0498	0.058
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Echinococcus granulosus	lachesin	0.0015	0.016	0.0157
Trichomonas vaginalis	glutaminase, putative	0.0264	0.6611	1
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0263	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.0691
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0774	1
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.019	0.4678	0.4676
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Schistosoma mansoni	hypothetical protein	0.0035	0.0673	0.065
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Echinococcus granulosus	roundabout 2	0.0015	0.016	0.0157
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.1138	0.1135
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0098	0.2299	0.2297
Echinococcus granulosus	bloom syndrome protein	0.0019	0.0276	0.0273
Schistosoma mansoni	nephrin	0.004	0.0805	0.0783
Echinococcus multilocularis	dnaJ subfamily B	0.0396	1	1
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0017	0.0214	0.0211
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0057	0.125	0.1248
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0263	0.1136
Echinococcus multilocularis	Immunoglobulin	0.0032	0.0597	0.0594
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0064	0.143	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.1138	0.1135
Brugia malayi	mbt repeat family protein	0.0046	0.0973	0.1131
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Brugia malayi	glutaminase DH11.1	0.0264	0.6611	0.7689
Echinococcus granulosus	hemicentin 1	0.0015	0.016	0.0157
Treponema pallidum	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0218	0.5413	1
Echinococcus multilocularis	bloom syndrome protein	0.0019	0.0276	0.0273
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0109	0.2599	0.3021
Echinococcus granulosus	GPCR family 2	0.0035	0.0673	0.067
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0673	0.067
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0774	0.0898
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0173	0.0198
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0173	0.0998
Entamoeba histolytica	recQ family helicase, putative	0.0019	0.0276	0.1794
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Echinococcus multilocularis	lysine specific demethylase 6a	0.0015	0.0173	0.017
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.0691
Brugia malayi	jmjC domain containing protein	0.0015	0.0173	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.0691
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0038	0.0768	0.0765
Entamoeba histolytica	recQ family DNA helicase	0.001	0.0033	0.0068
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Echinococcus granulosus	contactin	0.0015	0.016	0.0157
Chlamydia trachomatis	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0218	0.5413	0.3627
Echinococcus multilocularis	tyrosine protein kinase otk	0.0015	0.016	0.0157
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0735	0.0733
Schistosoma mansoni	hypothetical protein	0.0396	1	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.016	0.0157
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0263	0.0718
Mycobacterium tuberculosis	3-dehydroquinate synthase AroB	0.0139	0.337	1
Echinococcus multilocularis	phd:f box containing protein	0.0015	0.0173	0.017
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0019	0.0276	0.0273
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0017	0.0214	0.0211
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0015	0.0173	0.0166
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.0035
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0098	0.2299	0.2297
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0276	0.0321
Schistosoma mansoni	ap endonuclease	0.0038	0.0774	0.0752
Brugia malayi	Bloom's syndrome protein homolog	0.0019	0.0276	0.0321
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0173	0.0198
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0015	0.016	0.0157
Toxoplasma gondii	exonuclease III APE	0.0038	0.0774	0.0836
Echinococcus granulosus	SAM and MBT domain containing protein	0.0046	0.0973	0.097
Echinococcus granulosus	peroxidasin	0.0015	0.016	0.0157
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.114	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Loa Loa (eye worm)	mbt repeat family protein	0.0046	0.0973	0.1128
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0768	0.089
Echinococcus granulosus	dna polymerase eta	0.0019	0.0263	0.026
Schistosoma mansoni	roundabout	0.0015	0.016	0.0137
Schistosoma mansoni	tyrosine kinase	0.0098	0.2299	0.2281
Loa Loa (eye worm)	TK protein kinase	0.0106	0.2507	0.2914
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0673	0.0782
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0673	0.067
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0673	0.0779
Brugia malayi	jmjC domain containing protein	0.0015	0.0173	0.0201
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0109	0.2599	0.3023
Brugia malayi	mbt repeat family protein	0.0046	0.0973	0.1131
Brugia malayi	jmjC domain containing protein	0.0057	0.125	0.1454
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Onchocerca volvulus		0.0046	0.0973	0.1061
Schistosoma mansoni	hypothetical protein	0.0035	0.0673	0.065
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0263	0.1645
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0263	0.1645
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0263	0.026
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0015	0.016	0.0137
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0263	0.1136
Chlamydia trachomatis	phosphoshikimate 1-carboxyl vinyltransferase	0.0357	0.9002	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0673	0.0782
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0019	0.0276	0.1718
Loa Loa (eye worm)	MBCTL1	0.0053	0.1138	0.132
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0019	0.0276	0.0318
Loa Loa (eye worm)	RecQ helicase	0.0019	0.0276	0.0318
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.0774	0.4784
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0109	0.2599	0.3021
Schistosoma mansoni	hypothetical protein	0.0288	0.7226	0.7219
Trypanosoma brucei	unspecified product	0.0019	0.0263	0.1136
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0263	0.1645
Echinococcus granulosus	polycomb protein SCMH1	0.0046	0.0973	0.097
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.019	0.4678	0.4676
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0263	0.0303
Schistosoma mansoni	septate junction protein	0.0015	0.016	0.0137
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0064	0.143	0.1428
Leishmania major	DNA polymerase eta, putative	0.0019	0.0263	0.0718
Echinococcus granulosus	roundabout 2	0.0046	0.0976	0.0974
Echinococcus multilocularis	roundabout 2	0.0015	0.016	0.0157
Toxoplasma gondii	shikimate dehydrogenase substrate binding domain-containing protein	0.0357	0.9002	1
Echinococcus granulosus	Immunoglobulin	0.0032	0.0597	0.0594
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0263	0.026
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0276	0.1235
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.001	0.0033	0.0128
Schistosoma mansoni	glutaminase	0.0264	0.6611	0.6603
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0774	0.5305
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0774	0.0772
Echinococcus granulosus	neuroglian	0.004	0.0805	0.0803
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0019	0.0276	0.1718
Echinococcus granulosus	cpg binding protein	0.0029	0.0539	0.0537
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0015	0.0173	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0976	0.1133
Brugia malayi	hypothetical protein	0.0032	0.0597	0.0694
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0263	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0276	0.0318
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.1138	0.1323
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.016	0.0157
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0015	0.0173	0.0166
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0276	0.1738
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0098	0.2299	0.2297
Schistosoma mansoni	tyrosine kinase	0.0017	0.0208	0.0185
Echinococcus granulosus	neuroglian	0.0015	0.016	0.0157
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0038	0.0774	0.0585
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.1707	0.1986
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0032	0.0597	0.0594
Plasmodium vivax	JmjC domain containing protein	0.0015	0.0173	0.1986
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0276	0.0822
Echinococcus multilocularis	jumonji domain containing 1A	0.0015	0.0173	0.017
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0774	0.5337
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0046	0.0973	0.1061
Schistosoma mansoni	cpg binding protein	0.0029	0.0539	0.0517
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0064	0.143	0.1661
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.1138	0.1117
Schistosoma mansoni	cell adhesion molecule	0.0038	0.0768	0.0746
Echinococcus granulosus	roundabout 2	0.0015	0.016	0.0157
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0015	0.016	0.0157
Echinococcus multilocularis	polycomb protein SCMH1	0.0046	0.0973	0.097
Echinococcus multilocularis	JmjC domain containing protein 4	0.0015	0.0173	0.017
Echinococcus multilocularis	neuroglian	0.004	0.0805	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0263	0.026
Mycobacterium ulcerans	3-phosphoshikimate 1-carboxyvinyltransferase	0.0357	0.9002	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.143	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.016	0.0183
Schistosoma mansoni	hypothetical protein	0.0035	0.0673	0.065
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0109	0.2599	0.3023
Echinococcus multilocularis	neuroglian	0.0015	0.016	0.0157
Brugia malayi	jmjC domain containing protein	0.0015	0.0173	0.0201
Schistosoma mansoni	3-dehydroquinate synthase	0.0139	0.337	0.3355
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0263	0.026
Giardia lamblia	Sgs1 DNA helicase, putative	0.0019	0.0276	0.0254
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.016	0.0157
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0064	0.143	0.1663
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0735	0.0733
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.1303	0.1282
Trichomonas vaginalis	DNA helicase recq, putative	0.0019	0.0276	0.002
Schistosoma mansoni	cpg binding protein	0.0028	0.0498	0.0476
Echinococcus granulosus	tyrosine protein kinase otk	0.0015	0.016	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0973	0.1128
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0046	0.0973	0.0951
Onchocerca volvulus	Tyrosine kinase homolog	0.0311	0.7818	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0019	0.0276	0.0273
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0057	0.125	0.1248
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0218	0.5413	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0341	0.8597	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.1291	0.1271
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0263	0.1136
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.016	0.0183
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0064	0.143	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.0691
Trichomonas vaginalis	DNA helicase recq, putative	0.0019	0.0276	0.002
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.0691
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Loa Loa (eye worm)	glutaminase	0.0264	0.6611	0.7689
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0774	0.5019
Echinococcus multilocularis	roundabout 2	0.0015	0.016	0.0157
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0032	0.0597	0.0575
Echinococcus granulosus	twitchin	0.004	0.0805	0.0803
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0015	0.016	0.0183
Schistosoma mansoni	DNA helicase recq1	0.0019	0.0276	0.0253
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0263	0.0306

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki app (binding)	= 14.5 nM	Compound was tested for inhibitory activity against EPSP(5-enolpyruvylshikimate 3-phosphate) synthase in E. coli.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: 257484

Bibliographic References

No literature references available for this target.

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Detailed information for compound 160051