Detailed information for compound 1600540

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 373.247 | Formula: C17H17BrN4O
  • H donors: 2 H acceptors: 2 LogP: 3.87 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1c1cc2nc(N)nc(c2cc1C)N)Br
  • InChi: 1S/C17H17BrN4O/c1-3-23-15-5-4-10(18)7-12(15)11-8-14-13(6-9(11)2)16(19)22-17(20)21-14/h4-8H,3H2,1-2H3,(H4,19,20,21,22)
  • InChiKey: YCEDXTDKSNASDG-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Staphylococcus aureus Dihydrofolate reductase Starlite/ChEMBL References
Homo sapiens dihydrofolate reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi dihydrofolate reductase family protein Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus granulosus dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Loa Loa (eye worm) dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium ulcerans dihydrofolate reductase DfrA Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma japonicum ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma mansoni dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Chlamydia trachomatis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi Dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans hypothetical protein Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Cryptosporidium hominis chain A, crystal structure of Dhfr Dihydrofolate reductase   159 aa 150 aa 33.3 %
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   159 aa 150 aa 35.3 %
Onchocerca volvulus Putative dihydrofolate reductase Dihydrofolate reductase   159 aa 169 aa 29.6 %
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   159 aa 158 aa 27.2 %
Babesia bovis dihydrofolate reductase/thymidilate synthase Dihydrofolate reductase   159 aa 155 aa 36.8 %
Onchocerca volvulus Germline survival defective-1 homolog Dihydrofolate reductase   159 aa 159 aa 27.7 %
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Dihydrofolate reductase   159 aa 184 aa 27.7 %
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   159 aa 186 aa 26.3 %
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   159 aa 185 aa 25.4 %
Onchocerca volvulus Dihydrofolate reductase   159 aa 154 aa 25.3 %
Leishmania major dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   159 aa 186 aa 26.9 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase dihydrofolate reductase 187 aa 202 aa 29.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus peptide allatostatin:somatostatin 0.0943 0.5296 0.5295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0698 0.3898 0.3896
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0029 0.008 0.0078
Trichomonas vaginalis hypothetical protein 0.0214 0.1136 0.1125
Brugia malayi Dopamine receptor protein 1 0.0943 0.5296 0.5295
Schistosoma mansoni tubulin subunit beta 0.1768 1 1
Echinococcus multilocularis neuroendocrine convertase 2 0.0652 0.3631 0.3629
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0021 0.0019
Echinococcus granulosus tyrosine protein kinase csk 0.0038 0.0126 0.0124
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Schistosoma mansoni neuropeptide receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 0.0024 0.0047 0.0035
Leishmania major beta tubulin 0.1768 1 1
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0161 0.0159
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0047 0.0183 0.0181
Toxoplasma gondii subtilisin SUB5 0.0047 0.0183 0.0171
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0121 0.0108
Onchocerca volvulus 0.0943 0.5296 0.6896
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0079 0.0364 0.0362
Onchocerca volvulus 0.0943 0.5296 0.6896
Echinococcus granulosus neuropeptide receptor 0.0943 0.5296 0.5295
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0126 0.0124
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Echinococcus granulosus tyrosine protein kinase Fyn 0.0094 0.0446 0.0444
Echinococcus granulosus NCK adaptor protein 0.0029 0.008 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Brugia malayi ORL1-like opioid receptor 0.0943 0.5296 0.5295
Echinococcus multilocularis discoidin domain containing receptor 2 0.0017 0.0012 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0159 0.0818 0.0781
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0094 0.0446 0.0444
Echinococcus granulosus Tubulin beta 2C chain 0.1768 1 1
Brugia malayi Protein kinase domain containing protein 0.0019 0.0021 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0161 0.0148
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0631 0.3514 0.3506
Schistosoma mansoni histamine h1 receptor 0.0943 0.5296 0.5295
Brugia malayi sulfakinin receptor protein 0.0943 0.5296 0.5295
Toxoplasma gondii subtilisin SUB9 0.0047 0.0183 0.0171
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Brugia malayi SH2 domain containing protein 0.0019 0.0021 0.0019
Schistosoma mansoni amine GPCR 0.0943 0.5296 0.5295
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0631 0.3514 0.3512
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0262 0.1407 0.1405
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0047 0.0183 0.0752
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0114 0.0561 0.055
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Schistosoma mansoni dihydrofolate reductase 0.0415 0.2281 0.2279
Leishmania major beta tubulin 0.1768 1 1
Brugia malayi Protein kinase domain containing protein 0.0027 0.0064 0.0062
Onchocerca volvulus 0.0032 0.0092 0.0105
Brugia malayi hypothetical protein 0.0943 0.5296 0.5295
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0943 0.5296 0.5295
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0019 0.0021 0.0021
Echinococcus granulosus hypothetical protein 0.0943 0.5296 0.5295
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0161 0.0148
Brugia malayi SRC-1 0.0094 0.0446 0.0444
Toxoplasma gondii beta-tubulin, putative 0.1768 1 1
Brugia malayi Serotonin receptor 0.0943 0.5296 0.5295
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0094 0.0446 0.0444
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Echinococcus granulosus tm gpcr rhodopsin 0.0943 0.5296 0.5295
Echinococcus granulosus tachykinin peptides receptor 99D 0.0943 0.5296 0.5295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0943 0.5296 0.5295
Echinococcus granulosus tubulin beta 4A class IVa 0.1768 1 1
Leishmania major phosphoglycan beta 1,3 galactosyltransferase 5 0.0024 0.0047 0.0007
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0094 0.0446 0.0444
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.0983 0.0981
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0019 0.0021 0.0019
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0943 0.5296 0.5295
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0943 0.5296 0.5295
Brugia malayi beta-tubulin, identical 0.1768 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0094 0.0446 0.0444
Leishmania major beta tubulin 0.1768 1 1
Echinococcus granulosus fmrfamide receptor 0.0943 0.5296 0.5295
Echinococcus granulosus tyrosine protein kinase Lyn 0.0094 0.0449 0.0447
Plasmodium vivax subtilisin-like protease 2, putative 0.0047 0.0183 0.0171
Echinococcus multilocularis NCK adaptor protein 0.0029 0.008 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0021 0.0019
Echinococcus granulosus neuropeptide FF receptor 2 0.1392 0.7856 0.7856
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0056 0.0231 0.0228
Echinococcus granulosus tm gpcr rhodopsin 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Trypanosoma brucei calpain-like protein, putative 0.0114 0.0561 0.055
Onchocerca volvulus 0.0943 0.5296 0.6896
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0114 0.0561 0.0524
Brugia malayi hypothetical protein 0.0943 0.5296 0.5295
Echinococcus multilocularis fmrfamide receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Onchocerca volvulus 0.0943 0.5296 0.6896
Loa Loa (eye worm) hypothetical protein 0.0087 0.041 0.0408
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0943 0.5296 0.5295
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0094 0.0446 0.0444
Brugia malayi neuroendocrine convertase 1 precursor 0.0652 0.3631 0.3629
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0161 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0114 0.0561 0.055
Brugia malayi map kinase activated protein kinase protein 2 0.0188 0.0983 0.0981
Loa Loa (eye worm) deoxyribonuclease II family protein 0.0069 0.0308 0.0306
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0196 0.0194
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0262 0.1407 0.1396
Toxoplasma gondii subtilisin SUB12 0.0047 0.0183 0.0171
Brugia malayi hypothetical protein 0.0022 0.004 0.0038
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0019
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0188 0.0983 0.0981
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1136 0.1125
Brugia malayi hypothetical protein 0.0943 0.5296 0.5295
Brugia malayi Deoxyribonuclease II family protein 0.0069 0.0308 0.0306
Echinococcus multilocularis allatostatin A receptor 0.136 0.7674 0.7674
Schistosoma mansoni growth hormone secretagogue receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Schistosoma mansoni hypothetical protein 0.0943 0.5296 0.5295
Echinococcus multilocularis fmrfamide receptor 0.0943 0.5296 0.5295
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Echinococcus multilocularis tyrosine protein kinase Srms 0.0079 0.0364 0.0362
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0943 0.5296 0.5295
Trypanosoma brucei beta tubulin 0.1768 1 1
Schistosoma mansoni hypothetical protein 0.1682 0.9509 0.9509
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0041 0.0039
Onchocerca volvulus 0.002 0.0025 0.0017
Brugia malayi Sex muscle abnormal protein 5 0.0029 0.008 0.0078
Echinococcus multilocularis deoxyribonuclease ii 0.0069 0.0308 0.0306
Schistosoma mansoni opsin-like receptor 0.0943 0.5296 0.5295
Echinococcus granulosus tubulin subunit beta 0.1768 1 1
Entamoeba histolytica tubulin family protein 0.1768 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1136 0.1125
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0943 0.5296 0.5295
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0943 0.5296 0.5295
Echinococcus granulosus beta tubulin 0.1768 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0183 0.0181
Loa Loa (eye worm) endoprotease bli-4 0.1021 0.5738 0.5737
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Echinococcus granulosus g protein coupled receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.1061 0.5968 0.5967
Onchocerca volvulus 0.0943 0.5296 0.6896
Echinococcus granulosus rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Echinococcus granulosus nardilysin 0.0024 0.0047 0.0045
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0021 0.0019
Echinococcus multilocularis epidermal growth factor receptor 0.014 0.0709 0.0707
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.001
Schistosoma mansoni hypothetical protein 0.0943 0.5296 0.5295
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0114 0.0561 0.0524
Brugia malayi hypothetical protein 0.0035 0.0115 0.0113
Schistosoma mansoni site-1 peptidase (S08 family) 0.0047 0.0183 0.0181
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0943 0.5296 0.5295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0943 0.5296 0.5295
Loa Loa (eye worm) SRC-1 0.0094 0.0446 0.0444
Echinococcus multilocularis rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0161 0.0148
Echinococcus multilocularis tyrosine protein kinase shark 0.0019 0.0021 0.0019
Trichomonas vaginalis tubulin gamma chain, putative 0.1768 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1136 0.1125
Brugia malayi polk-prov protein 0.0033 0.01 0.0098
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0017 0.0012 0.001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0943 0.5296 0.5295
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0214 0.1136 0.1125
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1136 0.1125
Echinococcus granulosus dihydrofolate reductase 0.0415 0.2281 0.2279
Loa Loa (eye worm) hypothetical protein 0.0029 0.008 0.0078
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0041 0.0039
Brugia malayi Protein kinase domain containing protein 0.0019 0.0021 0.0019
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0114 0.0561 0.0517
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0034 0.0104 0.0102
Loa Loa (eye worm) hypothetical protein 0.1021 0.5738 0.5737
Brugia malayi neuropeptide F receptor 0.0943 0.5296 0.5295
Onchocerca volvulus 0.0943 0.5296 0.6896
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0114 0.0561 0.0517
Loa Loa (eye worm) neuropeptide F receptor 0.0943 0.5296 0.5295
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0161 0.0148
Brugia malayi hypothetical protein 0.0943 0.5296 0.5295
Schistosoma mansoni nck2/grb4 0.0029 0.008 0.0078
Loa Loa (eye worm) tubulin beta-1 chain 0.1768 1 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0114 0.0561 0.0517
Echinococcus granulosus tyrosine protein kinase Srms 0.0019 0.0021 0.0019
Schistosoma mansoni deoxyribonuclease II-related 0.0069 0.0308 0.0306
Schistosoma mansoni tyrosine kinase 0.0019 0.0021 0.0019
Echinococcus multilocularis G-protein coupled receptor, putative 0.0943 0.5296 0.5295
Echinococcus multilocularis neuropeptide Y receptor 0.0943 0.5296 0.5295
Onchocerca volvulus 0.0943 0.5296 0.6896
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0943 0.5296 0.5295
Toxoplasma gondii subtilisin SUB2 0.0047 0.0183 0.0171
Toxoplasma gondii subtilisin SUB10 0.0047 0.0183 0.0171
Schistosoma mansoni neuropeptide receptor 0.0943 0.5296 0.5295
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0159 0.0818 0.0775
Echinococcus granulosus sex peptide receptor 0.0943 0.5296 0.5295
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Echinococcus multilocularis neuropeptides capa receptor 0.0943 0.5296 0.5295
Schistosoma mansoni serine-type protease inhibitor 0.0865 0.485 0.4849
Echinococcus multilocularis Tubulin beta 2C chain 0.1768 1 1
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.001
Schistosoma mansoni amine GPCR 0.0943 0.5296 0.5295
Schistosoma mansoni peptide (allatostatin)-like receptor 0.136 0.7674 0.7674
Echinococcus granulosus growth factor receptor bound protein 2 0.0029 0.008 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0183 0.0171
Echinococcus granulosus tyrosine protein kinase Fyn 0.0094 0.0446 0.0444
Brugia malayi insulin-degrading enzyme 0.0024 0.0047 0.0045
Schistosoma mansoni biogenic amine receptor 0.0943 0.5296 0.5295
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0943 0.5296 0.5295
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0943 0.5296 0.5295
Onchocerca volvulus 0.0052 0.0211 0.026
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0161 0.0148
Leishmania major subtilisin-like serine peptidase 0.0047 0.0183 0.0144
Brugia malayi proprotein convertase 2 0.0652 0.3631 0.3629
Loa Loa (eye worm) TK protein kinase 0.0064 0.0279 0.0277
Schistosoma mansoni growth factor receptor-bound protein 0.0029 0.008 0.0078
Onchocerca volvulus 0.0943 0.5296 0.6896
Echinococcus multilocularis growth factor receptor bound protein 2 0.0029 0.008 0.0078
Brugia malayi putative neuropeptide receptor NPR1 0.0943 0.5296 0.5295
Echinococcus granulosus rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Schistosoma mansoni neuropeptide F-like receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Brugia malayi Subtilase family protein 0.0047 0.0183 0.0181
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0943 0.5296 0.5295
Schistosoma mansoni opsin-like receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0028 0.0071 0.0069
Onchocerca volvulus 0.0019 0.0021 0.0012
Echinococcus granulosus neuropeptides capa receptor 0.0943 0.5296 0.5295
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0058 0.0242 0.0196
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0161 0.0114
Echinococcus multilocularis neuropeptide Y receptor 0.0943 0.5296 0.5295
Trichomonas vaginalis tubulin epsilon chain, putative 0.1768 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0161 0.0114
Onchocerca volvulus 0.0943 0.5296 0.6896
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1136 0.1125
Echinococcus granulosus rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0943 0.5296 0.5295
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0183 0.0171
Echinococcus multilocularis discoidin domain receptor 0.0017 0.0012 0.001
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0106 0.0104
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0159 0.0818 0.0806
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0161 0.0148
Echinococcus multilocularis g protein coupled receptor 0.0943 0.5296 0.5295
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0943 0.5296 0.5295
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0161 0.0114
Brugia malayi Dopamine receptor protein 2 0.0943 0.5296 0.5295
Toxoplasma gondii sporozoite developmental protein 0.0024 0.0047 0.0035
Leishmania major beta tubulin 0.1768 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0196 0.0194
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0094 0.0446 0.0444
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0262 0.1407 0.1396
Echinococcus granulosus Furin 1 0.0262 0.1407 0.1405
Brugia malayi Furin-like cysteine rich region family protein 0.014 0.0709 0.0707
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0056 0.0231 0.0228
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0094 0.0446 0.0444
Onchocerca volvulus 0.0943 0.5296 0.6896
Echinococcus multilocularis neuropeptide receptor 0.0943 0.5296 0.5295
Echinococcus multilocularis serotonin receptor 0.1061 0.5968 0.5967
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Echinococcus granulosus 3'partial|nardilysin 0.0024 0.0047 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1136 0.1125
Echinococcus granulosus MAM 0.0022 0.004 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1136 0.1125
Loa Loa (eye worm) TK/ALK protein kinase 0.0027 0.0064 0.0062
Leishmania major beta tubulin 0.1768 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0075 0.034 0.0338
Echinococcus granulosus neuropeptides capa receptor 0.0943 0.5296 0.5295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Echinococcus multilocularis somatostatin receptor 0.0943 0.5296 0.5295
Brugia malayi G protein-coupled receptor F59B2.13 0.0943 0.5296 0.5295
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0943 0.5296 0.5295
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.004 0.0122
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0126 0.0124
Echinococcus multilocularis serotonin receptor 0.1061 0.5968 0.5967
Trichomonas vaginalis deoxyribonuclease II, putative 0.0069 0.0308 0.0297
Loa Loa (eye worm) tubulin beta chain 0.1768 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0415 0.2281 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0094 0.0446 0.0444
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0943 0.5296 0.5295
Plasmodium falciparum subtilisin-like protease 2 0.0047 0.0183 0.0171
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Echinococcus multilocularis dro:myosuppressin receptor 0.0943 0.5296 0.5295
Echinococcus multilocularis discoidin domain containing receptor 2 0.0017 0.0012 0.001
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0159 0.0818 0.0807
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0161 0.0148
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Echinococcus granulosus tyrosine protein kinase HCK 0.0064 0.0279 0.0277
Loa Loa (eye worm) deoxyribonuclease II family protein 0.0069 0.0308 0.0306
Echinococcus granulosus tyrosine protein kinase Src42A 0.0075 0.034 0.0338
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0114 0.0561 0.055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Schistosoma mansoni amine GPCR 0.0943 0.5296 0.5295
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0019 0.0021 0.0019
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0056 0.0231 0.0228
Echinococcus multilocularis MAM 0.0022 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.004 0.0038
Toxoplasma gondii subtilisin SUB1 0.0047 0.0183 0.0171
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0943 0.5296 0.5295
Brugia malayi Protein kinase domain containing protein 0.0019 0.0021 0.0019
Trypanosoma brucei beta tubulin 0.1768 1 1
Loa Loa (eye worm) proprotein convertase 2 0.0262 0.1407 0.1405
Onchocerca volvulus 0.0943 0.5296 0.6896
Loa Loa (eye worm) hypothetical protein 0.0022 0.004 0.0038
Leishmania major beta tubulin 0.1768 1 1
Loa Loa (eye worm) tubulin beta-2A chain 0.1768 1 1
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Entamoeba histolytica hypothetical protein 0.0035 0.0115 0.0115
Onchocerca volvulus 0.0019 0.0021 0.0012
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1021 0.5738 0.5737
Echinococcus multilocularis tyrosine kinase 0.0019 0.0021 0.0019
Schistosoma mansoni hypothetical protein 0.0056 0.0231 0.0228
Schistosoma mansoni opsin-like receptor 0.0943 0.5296 0.5295
Echinococcus granulosus g protein coupled receptor 0.0943 0.5296 0.5295
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0115 0.0113
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0183 0.0171
Loa Loa (eye worm) hypothetical protein 0.1194 0.6724 0.6724
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Loa Loa (eye worm) TK/EGFR protein kinase 0.014 0.0709 0.0707
Echinococcus granulosus neuroendocrine convertase 2 0.0652 0.3631 0.3629
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.004 0.0027
Giardia lamblia Beta tubulin 0.1768 1 1
Toxoplasma gondii subtilisin SUB7 0.0047 0.0183 0.0171
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0943 0.5296 0.5295
Schistosoma mansoni biogenic amine receptor 0.0943 0.5296 0.5295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0019 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0115 0.0113
Trypanosoma brucei unspecified product 0.0037 0.0121 0.0108
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Schistosoma mansoni tubulin subunit beta 0.1768 1 1
Brugia malayi SH2 domain containing protein 0.0052 0.0211 0.0209
Schistosoma mansoni myosin xvIII 0.0943 0.5296 0.5295
Entamoeba histolytica hypothetical protein 0.0035 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0022 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.004 0.0038
Echinococcus multilocularis orexin receptor type 2 0.0943 0.5296 0.5295
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0943 0.5296 0.6896
Echinococcus multilocularis neuropeptide receptor A26 0.0943 0.5296 0.5295
Echinococcus granulosus biogenic amine 5HT receptor 0.1061 0.5968 0.5967
Onchocerca volvulus 0.0019 0.0021 0.0012
Echinococcus granulosus tyrosine protein kinase Blk 0.0079 0.0364 0.0362
Schistosoma mansoni hypothetical protein 0.0214 0.1136 0.1134
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0079 0.0364 0.0362
Brugia malayi hypothetical protein 0.0943 0.5296 0.5295
Schistosoma mansoni tyrosine kinase 0.0094 0.0446 0.0444
Loa Loa (eye worm) TK protein kinase 0.0079 0.0364 0.0362
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0159 0.0818 0.0807
Loa Loa (eye worm) TK/CSK protein kinase 0.0038 0.0126 0.0124
Plasmodium falciparum subtilisin-like protease 1 0.0047 0.0183 0.0171
Echinococcus granulosus somatostatin receptor 0.0943 0.5296 0.5295
Schistosoma mansoni hypothetical protein 0.0056 0.0231 0.0228
Echinococcus multilocularis discoidin domain containing receptor 2 0.0017 0.0012 0.001
Leishmania major beta tubulin 0.1768 1 1
Trypanosoma brucei hypothetical protein 0.0114 0.0561 0.055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0943 0.5296 0.5295
Toxoplasma gondii beta tubulin 0.1768 1 1
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Brugia malayi neuropeptide F receptor 0.0943 0.5296 0.5295
Schistosoma mansoni neuropeptide F-like receptor 0.0943 0.5296 0.5295
Trichomonas vaginalis tubulin beta chain, putative 0.1768 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0943 0.5296 0.5295
Entamoeba histolytica tubulin family protein 0.1768 1 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1768 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0943 0.5296 0.5295
Entamoeba histolytica hypothetical protein 0.0035 0.0115 0.0115
Echinococcus multilocularis beta tubulin 0.1768 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.1768 1 1
Echinococcus multilocularis neuropeptide receptor 0.0943 0.5296 0.5295
Echinococcus granulosus tyrosine kinase 0.0079 0.0364 0.0362
Echinococcus granulosus membrane bound transcription factor site 1 0.0047 0.0183 0.0181
Loa Loa (eye worm) hypothetical protein 0.005 0.0196 0.0194
Trichomonas vaginalis deoxyribonuclease II precursor, putative 0.0069 0.0308 0.0297
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Schistosoma mansoni biogenic amine (5HT) receptor 0.1061 0.5968 0.5967
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0114 0.0561 0.055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0159 0.0818 0.0807
Echinococcus granulosus tyrosine protein kinase csk 0.0038 0.0126 0.0124
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1308 0.7374 0.7373
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0631 0.3514 0.3512
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Brugia malayi hypothetical protein 0.0943 0.5296 0.5295
Chlamydia trachomatis dihydrofolate reductase 0.0415 0.2281 1
Echinococcus granulosus tyrosine protein kinase csk 0.0038 0.0126 0.0124
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0698 0.3898 0.3896
Echinococcus multilocularis membrane bound transcription factor site 1 0.0047 0.0183 0.0181
Trypanosoma brucei RNA helicase, putative 0.0102 0.0494 0.0482
Brugia malayi GnHR receptor homolog 0.0943 0.5296 0.5295
Toxoplasma gondii subtilisin SUB8 0.0047 0.0183 0.0171
Schistosoma mansoni tyrosine kinase 0.0221 0.1175 0.1173
Trypanosoma brucei beta tubulin 0.1768 1 1
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0056 0.0231 0.0228
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0415 0.2281 1
Echinococcus granulosus furin 0.1021 0.5738 0.5737
Schistosoma mansoni amine GPCR 0.0943 0.5296 0.5295
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0094 0.0446 0.0444
Leishmania major beta tubulin 0.1768 1 1
Schistosoma mansoni neuropeptide receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) BEN-1 protein 0.1768 1 1
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Toxoplasma gondii insulysin, putative 0.0022 0.004 0.0028
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0047 0.0183 0.0752
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0943 0.5296 0.5295
Loa Loa (eye worm) BEN-1 protein 0.1768 1 1
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0024 0.0047 0.0045
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0114 0.0561 0.055
Echinococcus multilocularis Tubulin beta 2C chain 0.1768 1 1
Schistosoma mansoni discoidin domain receptor 0.0017 0.0012 0.001
Schistosoma mansoni hypothetical protein 0.0056 0.0231 0.0228
Echinococcus multilocularis nardilysin 0.0024 0.0047 0.0045
Echinococcus multilocularis tyrosine protein kinase Abl 0.0117 0.0577 0.0575
Schistosoma mansoni tubulin subunit beta 0.1768 1 1
Brugia malayi putative neuropeptide receptor 0.0943 0.5296 0.5295
Echinococcus granulosus G protein coupled receptor 139 0.0943 0.5296 0.5295
Brugia malayi Dihydrofolate reductase 0.0415 0.2281 0.2279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0161 0.0114
Trypanosoma brucei calpain, putative 0.0114 0.0561 0.055
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0034 0.0104 0.0102
Echinococcus granulosus tyrosine protein kinase shark 0.0019 0.0021 0.0019
Schistosoma mansoni adenoreceptor 0.0943 0.5296 0.5295
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0047 0.0183 0.0752
Trypanosoma cruzi beta tubulin, putative 0.1768 1 1
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Echinococcus granulosus Tubulin beta 2C chain 0.1768 1 1
Schistosoma mansoni tyrosine kinase 0.0094 0.0446 0.0444
Schistosoma mansoni tyrosine kinase 0.0067 0.0294 0.0292
Onchocerca volvulus 0.0943 0.5296 0.6896
Entamoeba histolytica protein kinase, putative 0.0064 0.0279 0.0279
Brugia malayi RE15519p 0.0943 0.5296 0.5295
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0126 0.0124
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Brugia malayi protein-tyrosine kinase 0.0079 0.0364 0.0362
Brugia malayi Tyrosine-protein kinase abl-1 0.0117 0.0577 0.0575
Loa Loa (eye worm) hypothetical protein 0.136 0.7674 0.7674
Onchocerca volvulus 0.0943 0.5296 0.6896
Echinococcus granulosus neuropeptide receptor A26 0.0943 0.5296 0.5295
Echinococcus multilocularis Furin 1 0.0262 0.1407 0.1405
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Loa Loa (eye worm) beta-tubulin 0.1768 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Trichomonas vaginalis tubulin epsilon chain, putative 0.1768 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0262 0.1407 0.1396
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.01 0.0088
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0021 0.0019
Brugia malayi Deoxyribonuclease II family protein 0.0069 0.0308 0.0306
Toxoplasma gondii subtilisin SUB4 0.0047 0.0183 0.0171
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0114 0.0561 0.055
Leishmania major beta tubulin 0.1768 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0021 0.0019
Schistosoma mansoni tubulin subunit beta 0.1768 1 1
Schistosoma mansoni tyrosine kinase 0.0034 0.0104 0.0102
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0943 0.5296 0.5295
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0033 0.01 0.0098
Schistosoma mansoni hypothetical protein 0.0035 0.0115 0.0113
Echinococcus granulosus rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0047 0.0183 0.0181
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0196 0.0194
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0188 0.0983 0.0981
Schistosoma mansoni nardilysin (M16 family) 0.0024 0.0047 0.0045
Schistosoma mansoni discoidin domain receptor 0.0017 0.0012 0.001
Schistosoma mansoni apoptosis regulator bax 0.0056 0.0231 0.0228
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0047 0.0183 0.0104
Onchocerca volvulus 0.0943 0.5296 0.6896
Plasmodium vivax subtilisin-like protease 1 0.0047 0.0183 0.0171
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0021 0.0019
Echinococcus granulosus Tubulin beta 2C chain 0.1768 1 1
Brugia malayi hypothetical protein 0.0943 0.5296 0.5295
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0943 0.5296 0.5295
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0021 0.0019
Echinococcus granulosus g-protein coupled receptor 0.0943 0.5296 0.5295
Brugia malayi G protein-coupled receptor 0.0943 0.5296 0.5295
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.01 0.0088
Brugia malayi hypothetical protein 0.0019 0.0021 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0183 0.0171
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Echinococcus granulosus dna polymerase kappa 0.0044 0.0161 0.0159
Loa Loa (eye worm) hypothetical protein 0.0034 0.0106 0.0104
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0943 0.5296 0.5295
Echinococcus multilocularis g-protein coupled receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.1392 0.7856 0.7856
Brugia malayi Protein kinase domain containing protein 0.0019 0.0021 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0047 0.0183 0.0181
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0017 0.0012 0.001
Echinococcus granulosus dro:myosuppressin receptor 0.0943 0.5296 0.5295
Schistosoma mansoni neuropeptide receptor 0.0943 0.5296 0.5295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Brugia malayi Variant SH3 domain containing protein 0.0029 0.008 0.0078
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Echinococcus granulosus neuropeptide s receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.039 0.2136 0.2135
Onchocerca volvulus 0.0943 0.5296 0.6896
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0943 0.5296 0.5295
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0017 0.0012 0.001
Schistosoma mansoni tubulin subunit beta 0.1768 1 1
Brugia malayi Serotonin receptor 0.1389 0.7836 0.7835
Schistosoma mansoni septate junction protein 0.0017 0.0012 0.001
Onchocerca volvulus 0.0022 0.0036 0.0031
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0943 0.5296 0.5295
Onchocerca volvulus 0.136 0.7674 1
Echinococcus multilocularis neuropeptide s receptor 0.0943 0.5296 0.5295
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0114 0.0561 0.055
Echinococcus granulosus 7tm_1 domain containing protein 0.0943 0.5296 0.5295
Loa Loa (eye worm) TYRA-2 protein 0.0943 0.5296 0.5295
Brugia malayi hypothetical protein 0.0943 0.5296 0.5295
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0631 0.3514 0.3506
Echinococcus granulosus tm gpcr rhodopsin 0.1745 0.9868 0.9868
Echinococcus multilocularis 0.0806 0.4514 0.4513
Trichomonas vaginalis tubulin alpha chain, putative 0.1768 1 1
Brugia malayi G-protein coupled receptor 0.0943 0.5296 0.5295
Brugia malayi Tachykinin-like peptides receptor 99D 0.1392 0.7856 0.7856
Echinococcus multilocularis beta tubulin 0.1768 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1745 0.9868 0.9868
Brugia malayi larval opioid receptor 0.0943 0.5296 0.5295
Brugia malayi Melatonin receptor type 1A 0.0943 0.5296 0.5295
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0047 0.0183 0.0104
Echinococcus granulosus orexin receptor type 2 0.0943 0.5296 0.5295
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0047 0.0183 0.0752
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1136 0.1125
Trypanosoma brucei subtilisin peptidase 0.0047 0.0183 0.017
Echinococcus multilocularis neuropeptides capa receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) dihydrofolate reductase 0.0415 0.2281 0.2279
Echinococcus granulosus epidermal growth factor receptor 0.014 0.0709 0.0707
Loa Loa (eye worm) insulin-degrading enzyme 0.0024 0.0047 0.0045
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0094 0.0446 0.0444
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0943 0.5296 0.5295
Toxoplasma gondii subtilisin SUB6 0.0047 0.0183 0.0171
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0943 0.5296 0.5295
Echinococcus granulosus beta tubulin 0.1768 1 1
Leishmania major beta tubulin 0.1768 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Echinococcus granulosus discoidin domain receptor 0.0017 0.0012 0.001
Onchocerca volvulus 0.0022 0.004 0.0037
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0047 0.0183 0.0137
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0029 0.008 0.0078
Leishmania major beta tubulin 0.1768 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0048 0.0187 0.0185
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0262 0.1407 0.1396
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0161 0.0148
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0094 0.0446 0.0444
Echinococcus multilocularis nardilysin 0.0024 0.0047 0.0045
Echinococcus granulosus discoidin domain containing receptor 2 0.0017 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0188 0.0983 0.0981
Echinococcus granulosus deoxyribonuclease ii 0.0069 0.0308 0.0306
Mycobacterium leprae Possible secreted protease 0.0047 0.0183 0.0752
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0021 0.0019
Schistosoma mansoni hypothetical protein 0.0102 0.0494 0.0492
Echinococcus multilocularis neuropeptide FF receptor 2 0.1392 0.7856 0.7856
Echinococcus multilocularis Tubulin beta 2C chain 0.1768 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0943 0.5296 0.5295
Giardia lamblia Beta tubulin 0.1768 1 1
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0943 0.5296 0.5295
Schistosoma mansoni tyrosine kinase 0.0019 0.0021 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Echinococcus granulosus Tubulin beta 2C chain 0.1768 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0029 0.008 0.0078
Schistosoma mansoni adapter molecule crk 0.0029 0.008 0.0078
Brugia malayi AKH receptor 0.0943 0.5296 0.5295
Plasmodium falciparum subtilisin-like protease 3 0.0047 0.0183 0.0171
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0094 0.0446 0.0444
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0943 0.5296 0.5295
Onchocerca volvulus 0.0022 0.004 0.0037
Plasmodium vivax subtilisin-like serine protease, putative 0.0047 0.0183 0.0171
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0943 0.5296 0.5295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0943 0.5296 0.5295
Echinococcus granulosus discoidin domain containing receptor 2 0.0017 0.0012 0.001
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0056 0.0231 0.0228
Onchocerca volvulus 0.0943 0.5296 0.6896
Echinococcus granulosus neuropeptide Y receptor 0.0943 0.5296 0.5295
Brugia malayi G-protein coupled receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0161 0.0149
Echinococcus multilocularis tyrosine protein kinase HCK 0.0064 0.0279 0.0277
Loa Loa (eye worm) tubulin beta-4 chain 0.1768 1 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0236 0.126 0.1258
Echinococcus granulosus rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Loa Loa (eye worm) TK/ABL protein kinase 0.0236 0.126 0.1258
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Schistosoma mansoni dock 0.0017 0.0012 0.001
Brugia malayi hypothetical protein 0.0943 0.5296 0.5295
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0214 0.1136 0.1125
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0183 0.0171
Leishmania major beta tubulin 0.1768 1 1
Echinococcus granulosus dnaJ subfamily B 0.1682 0.9509 0.9509
Trichomonas vaginalis DNAse2-prov protein, putative 0.0069 0.0308 0.0297
Echinococcus multilocularis sex peptide receptor 0.0943 0.5296 0.5295
Schistosoma mansoni tyrosine kinase 0.014 0.0709 0.0707
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0024 0.0047 0.0045
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0415 0.2281 1
Toxoplasma gondii beta-1 tubulin, putative 0.1768 1 1
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0047 0.0183 0.0181
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0115 0.0113
Echinococcus granulosus neuropeptide receptor 0.0943 0.5296 0.5295
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Schistosoma mansoni hypothetical protein 0.0022 0.004 0.0038
Schistosoma mansoni alpha-1 adrenergic receptor 0.0943 0.5296 0.5295
Echinococcus granulosus Tubulin beta 2C chain 0.1768 1 1
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Loa Loa (eye worm) melatonin receptor type 1A 0.0943 0.5296 0.5295
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0943 0.5296 0.5295
Echinococcus multilocularis G protein coupled receptor 139 0.0943 0.5296 0.5295
Loa Loa (eye worm) apoptosis regulator protein 0.0056 0.0231 0.0228
Echinococcus granulosus alpha 1A adrenergic receptor 0.0943 0.5296 0.5295
Echinococcus multilocularis Tubulin beta 2C chain 0.1768 1 1
Schistosoma mansoni hypothetical protein 0.0943 0.5296 0.5295
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1136 0.1125
Brugia malayi follicle stimulating hormone receptor 0.0943 0.5296 0.5295
Echinococcus granulosus tyrosine protein kinase Fyn 0.0094 0.0446 0.0444
Loa Loa (eye worm) hypothetical protein 0.1061 0.5968 0.5967
Brugia malayi Variant SH3 domain containing protein 0.0029 0.008 0.0078
Echinococcus granulosus tubulin beta 1 chain 0.1768 1 1
Leishmania major beta tubulin 0.1768 1 1
Echinococcus granulosus allatostatin A receptor 0.136 0.7674 0.7674
Echinococcus multilocularis dnaJ subfamily B 0.1682 0.9509 0.9509
Toxoplasma gondii subtilisin SUB11 0.0047 0.0183 0.0171
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0943 0.5296 0.5295
Schistosoma mansoni tubulin subunit beta 0.1768 1 1
Trichomonas vaginalis tubulin, putative 0.1768 1 1
Brugia malayi Dopamine receptor 0.0943 0.5296 0.5295
Echinococcus granulosus serotonin receptor 0.0943 0.5296 0.5295
Leishmania major beta tubulin 0.1768 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0943 0.5296 0.5295
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0025 0.0023
Onchocerca volvulus Neuropeptide F receptor homolog 0.0943 0.5296 0.6896
Echinococcus multilocularis g protein coupled receptor 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Echinococcus multilocularis dihydrofolate reductase 0.0415 0.2281 0.2279
Echinococcus multilocularis tyrosine protein kinase Blk 0.0079 0.0364 0.0362
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0047 0.0183 0.0752
Echinococcus multilocularis g protein coupled receptor 0.0943 0.5296 0.5295
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0047 0.0183 0.0181
Brugia malayi endoprotease bli-4 precursor 0.1021 0.5738 0.5737
Echinococcus granulosus 7TM GPCR rhodopsin 0.0943 0.5296 0.5295
Brugia malayi celfurPC protein 0.0806 0.4514 0.4513
Giardia lamblia High cysteine membrane protein Group 2 0.0369 0.2019 0.1987
Schistosoma mansoni amine GPCR 0.0943 0.5296 0.5295
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0126 0.0124
Schistosoma mansoni neuropeptide f receptor 76f 0.0943 0.5296 0.5295
Schistosoma mansoni btb and poz domain-containing protein 0.0017 0.0012 0.001
Schistosoma mansoni biogenic amine receptor 0.0943 0.5296 0.5295
Echinococcus multilocularis c src tyrosine kinase 0.0067 0.0294 0.0292
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0943 0.5296 0.5295
Leishmania major beta tubulin 0.1768 1 1
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Trypanosoma brucei beta tubulin 0.1768 1 1
Onchocerca volvulus 0.0047 0.0183 0.0223
Echinococcus granulosus tyrosine protein kinase Src42A 0.0094 0.0446 0.0444
Leishmania major beta tubulin 0.1768 1 1
Echinococcus granulosus tyrosine kinase 0.0019 0.0021 0.0019
Brugia malayi Tyrosine-protein kinase abl-1 0.0134 0.0677 0.0675
Trypanosoma brucei peptidase, putative 0.0024 0.0047 0.0034
Schistosoma mansoni nardilysin (M16 family) 0.0024 0.0047 0.0045
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Schistosoma mansoni furin-1 (S08 family) 0.0437 0.2407 0.2405
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0943 0.5296 0.5295
Leishmania major beta tubulin 0.1768 1 1
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0114 0.0561 0.0517
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0943 0.5296 0.5295
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0047 0.0183 0.0104
Brugia malayi Protein kinase domain containing protein 0.0022 0.0036 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0943 0.5296 0.5295
Loa Loa (eye worm) hypothetical protein 0.0943 0.5296 0.5295
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0029 0.008 0.0078
Echinococcus multilocularis tubulin beta 1 chain 0.1768 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0262 0.1407 0.1396
Giardia lamblia Beta tubulin 0.1768 1 1
Plasmodium vivax tubulin beta chain, putative 0.1768 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.0115 0.0115
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0114 0.0561 0.0517
Echinococcus granulosus c src tyrosine kinase 0.0067 0.0294 0.0292
Brugia malayi Protein kinase domain containing protein 0.0019 0.0021 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0262 0.1407 0.1396
Giardia lamblia Furin precursor putative serine protease 0.0214 0.1136 0.1101
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0034 0.0104 0.0102
Plasmodium falciparum tubulin beta chain 0.1768 1 1
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0214 0.1136 0.1125
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0161 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0161 0.0148
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0047 0.0183 0.0752
Echinococcus granulosus g protein coupled receptor 0.0943 0.5296 0.5295
Schistosoma mansoni biogenic amine (5HT) receptor 0.1308 0.7374 0.7373
Echinococcus granulosus biogenic amine 5HT receptor 0.1308 0.7374 0.7373
Echinococcus granulosus rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Echinococcus multilocularis tubulin subunit beta 0.1768 1 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0114 0.0561 0.0524
Brugia malayi hypothetical protein 0.0943 0.5296 0.5295
Leishmania major beta tubulin 0.1768 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Loa Loa (eye worm) G-protein coupled receptor 0.0943 0.5296 0.5295
Schistosoma mansoni hypothetical protein 0.0034 0.0106 0.0104
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0058 0.0242 0.023
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0058 0.0242 0.0196
Loa Loa (eye worm) subtilase 0.0047 0.0183 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1136 0.1125
Echinococcus granulosus tyrosine protein kinase ABL1 0.0236 0.126 0.1258
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0943 0.5296 0.5295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0943 0.5296 0.5295
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1136 0.1125
Onchocerca volvulus 0.0019 0.0021 0.0012
Brugia malayi dihydrofolate reductase family protein 0.0415 0.2281 0.2279
Echinococcus granulosus insulin degrading enzyme 0.0024 0.0047 0.0045
Schistosoma mansoni serine-type protease inhibitor 0.0865 0.485 0.4849
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Echinococcus multilocularis insulin degrading enzyme 0.0024 0.0047 0.0045
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Schistosoma mansoni site-1 peptidase (S08 family) 0.0047 0.0183 0.0181
Echinococcus granulosus discoidin domain containing receptor 2 0.0017 0.0012 0.001
Trypanosoma cruzi subtilisin peptidase 0.0047 0.0183 0.0137
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0047 0.0183 0.0181
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0047 0.0183 0.0171
Loa Loa (eye worm) neuropeptide F receptor 0.0943 0.5296 0.5295
Schistosoma mansoni hypothetical protein 0.0943 0.5296 0.5295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0943 0.5296 0.5295
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0161 0.0148

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.76 nM Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spectrophotometry ChEMBL. 21831637
Ki (binding) = 11.1 nM Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spectrophotometry ChEMBL. 21831637
MIC (functional) = 32 ug ml-1 Antibacterial activity against Escherichia coli ATCC 35218 by CLSI microdilution method ChEMBL. 21831637

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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