TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 344.62 | Formula: C15H12Cl3NO2
H donors: 0 H acceptors: 1 LogP: 5.52 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: C=Cc1ccc(c(n1)Cl)OCCOc1ccc(cc1Cl)Cl
InChi: 1S/C15H12Cl3NO2/c1-2-11-4-6-14(15(18)19-11)21-8-7-20-13-5-3-10(16)9-12(13)17/h2-6,9H,1,7-8H2
InChiKey: LNMIMKUXSGGSCZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sphingosine-1-phosphate receptor 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0203	0.6794	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Onchocerca volvulus		0.0203	0.6794	0.5
Brugia malayi	Melatonin receptor type 1A	0.0203	0.6794	0.6614
Onchocerca volvulus		0.0203	0.6794	0.5
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus granulosus	Tubulin beta 2C chain	0.0291	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0203	0.6794	0.5
Brugia malayi	RE15519p	0.0203	0.6794	0.6614
Brugia malayi	follicle stimulating hormone receptor	0.0203	0.6794	0.6614
Brugia malayi	hypothetical protein	0.0203	0.6794	0.6614
Brugia malayi	neuropeptide F receptor	0.0203	0.6794	0.6614
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0203	0.6794	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0203	0.6794	0.6479
Trypanosoma brucei	beta tubulin	0.0291	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Giardia lamblia	Beta tubulin	0.0291	1	1
Leishmania major	beta tubulin	0.0291	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Echinococcus granulosus	beta tubulin	0.0291	1	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Entamoeba histolytica	tubulin family protein	0.0291	1	0.5
Toxoplasma gondii	beta tubulin	0.0291	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0203	0.6794	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0203	0.6794	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Onchocerca volvulus		0.0203	0.6794	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Echinococcus multilocularis	G protein coupled receptor 139	0.0203	0.6794	0.6479
Entamoeba histolytica	tubulin family protein	0.0291	1	0.5
Echinococcus granulosus	fmrfamide receptor	0.0203	0.6794	0.6479
Echinococcus multilocularis	Tubulin beta 2C chain	0.0291	1	1
Onchocerca volvulus		0.0203	0.6794	0.5
Onchocerca volvulus		0.0203	0.6794	0.5
Echinococcus multilocularis	tubulin beta 1 chain	0.0291	1	1
Trypanosoma brucei	beta tubulin	0.0291	1	1
Echinococcus granulosus	neuropeptide receptor	0.0203	0.6794	0.6479
Onchocerca volvulus		0.0203	0.6794	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0203	0.6794	0.6479
Leishmania major	beta tubulin	0.0291	1	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0291	1	1
Loa Loa (eye worm)	TYRA-2 protein	0.0203	0.6794	0.6614
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0203	0.6794	0.6479
Brugia malayi	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus granulosus	7tm_1 domain containing protein	0.0203	0.6794	0.6479
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0203	0.6794	0.6479
Brugia malayi	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus granulosus	Tubulin beta 2C chain	0.0291	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0164	0.0164
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0203	0.6794	0.6479
Trypanosoma brucei	unspecified product	0.0035	0.0653	0.0653
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0894	0.0894
Echinococcus granulosus	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Echinococcus granulosus	neuropeptide Y receptor	0.0203	0.6794	0.6479
Echinococcus granulosus	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus multilocularis	g protein coupled receptor	0.0203	0.6794	0.6479
Loa Loa (eye worm)	G-protein coupled receptor	0.0203	0.6794	0.6614
Echinococcus multilocularis	beta tubulin	0.0291	1	1
Loa Loa (eye worm)	tubulin beta chain	0.0291	1	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0203	0.6794	0.6479
Echinococcus multilocularis	Tubulin beta 2C chain	0.0291	1	1
Leishmania major	beta tubulin	0.0291	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0291	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0291	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0203	0.6794	0.6479
Onchocerca volvulus		0.0203	0.6794	0.5
Leishmania major	beta tubulin	0.0291	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.0203	0.6794	0.6479
Trypanosoma brucei	beta tubulin	0.0291	1	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus multilocularis	dro:myosuppressin receptor	0.0203	0.6794	0.6479
Echinococcus multilocularis	neuropeptide receptor A26	0.0203	0.6794	0.6479
Echinococcus granulosus	7TM GPCR rhodopsin	0.0203	0.6794	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Schistosoma mansoni	tubulin subunit beta	0.0291	1	1
Schistosoma mansoni	tubulin subunit beta	0.0291	1	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Onchocerca volvulus		0.0203	0.6794	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0203	0.6794	0.6479
Schistosoma mansoni	tubulin subunit beta	0.0291	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0203	0.6794	0.6614
Echinococcus multilocularis	g-protein coupled receptor	0.0203	0.6794	0.6479
Brugia malayi	hypothetical protein	0.0203	0.6794	0.6614
Brugia malayi	G-protein coupled receptor	0.0203	0.6794	0.6614
Brugia malayi	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus multilocularis	serotonin receptor	0.0203	0.6794	0.6479
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0203	0.6794	0.6614
Onchocerca volvulus		0.0203	0.6794	0.5
Brugia malayi	hypothetical protein	0.0203	0.6794	0.6614
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0203	0.6794	0.6614
Brugia malayi	Dopamine receptor	0.0203	0.6794	0.6614
Echinococcus granulosus	g protein coupled receptor	0.0203	0.6794	0.6479
Schistosoma mansoni	tubulin subunit beta	0.0291	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0291	1	1
Onchocerca volvulus		0.0203	0.6794	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0203	0.6794	0.6479
Echinococcus granulosus	sex peptide receptor	0.0203	0.6794	0.6479
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Echinococcus granulosus	Tubulin beta 2C chain	0.0291	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Brugia malayi	G-protein coupled receptor	0.0203	0.6794	0.6614
Brugia malayi	Dopamine receptor protein 2	0.0203	0.6794	0.6614
Brugia malayi	Dopamine receptor protein 1	0.0203	0.6794	0.6614
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0203	0.6794	0.6614
Leishmania major	beta tubulin	0.0291	1	1
Echinococcus multilocularis	beta tubulin	0.0291	1	1
Leishmania major	beta tubulin	0.0291	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0203	0.6794	0.6479
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0894	0.0894
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0203	0.6794	0.6479
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0203	0.6794	0.6479
Onchocerca volvulus		0.0203	0.6794	0.5
Onchocerca volvulus		0.0203	0.6794	0.5
Echinococcus multilocularis	serotonin receptor	0.0203	0.6794	0.6479
Brugia malayi	putative neuropeptide receptor NPR1	0.0203	0.6794	0.6614
Echinococcus granulosus	tm gpcr rhodopsin	0.0203	0.6794	0.6479
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0203	0.6794	0.6479
Trichomonas vaginalis	tubulin gamma chain, putative	0.0291	1	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus multilocularis	neuropeptide Y receptor	0.0203	0.6794	0.6479
Echinococcus granulosus	neuropeptide s receptor	0.0203	0.6794	0.6479
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0894	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus multilocularis	Tubulin beta 2C chain	0.0291	1	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Onchocerca volvulus		0.0203	0.6794	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0203	0.6794	0.6479
Brugia malayi	neuropeptide F receptor	0.0203	0.6794	0.6614
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0203	0.6794	0.6614
Loa Loa (eye worm)	tubulin beta-2A chain	0.0291	1	1
Echinococcus granulosus	hypothetical protein	0.0203	0.6794	0.6479
Echinococcus multilocularis	sex peptide receptor	0.0203	0.6794	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Loa Loa (eye worm)	BEN-1 protein	0.0291	1	1
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.0894	0.5
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0291	1	1
Brugia malayi	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus granulosus	beta tubulin	0.0291	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Echinococcus granulosus	neuropeptide Y receptor	0.0203	0.6794	0.6479
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0203	0.6794	0.6614
Echinococcus granulosus	allatostatin A receptor	0.0203	0.6794	0.6479
Loa Loa (eye worm)	melatonin receptor type 1A	0.0203	0.6794	0.6614
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0203	0.6794	0.6479
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0894	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus multilocularis	allatostatin A receptor	0.0203	0.6794	0.6479
Trichomonas vaginalis	tubulin alpha chain, putative	0.0291	1	1
Brugia malayi	ORL1-like opioid receptor	0.0203	0.6794	0.6614
Echinococcus granulosus	tubulin beta 4A class IVa	0.0291	1	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus granulosus	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Leishmania major	beta tubulin	0.0291	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0203	0.6794	0.6614
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0894	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus multilocularis	neuropeptides capa receptor	0.0203	0.6794	0.6479
Echinococcus granulosus	g protein coupled receptor	0.0203	0.6794	0.6479
Leishmania major	beta tubulin	0.0291	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0203	0.6794	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus multilocularis	Tubulin beta 2C chain	0.0291	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0291	1	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Onchocerca volvulus		0.0203	0.6794	0.5
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0894	0.0894
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0203	0.6794	0.6614
Trypanosoma brucei	beta tubulin	0.0291	1	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0894	0.0894
Loa Loa (eye worm)	beta-tubulin	0.0291	1	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0203	0.6794	0.6614
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0203	0.6794	0.6479
Echinococcus granulosus	tubulin subunit beta	0.0291	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0203	0.6794	0.6479
Leishmania major	beta tubulin	0.0291	1	1
Brugia malayi	hypothetical protein	0.0203	0.6794	0.6614
Leishmania major	beta tubulin	0.0291	1	1
Trichomonas vaginalis	tubulin, putative	0.0291	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0203	0.6794	0.6479
Schistosoma mansoni	tubulin subunit beta	0.0291	1	1
Onchocerca volvulus		0.0203	0.6794	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0203	0.6794	0.6479
Trypanosoma cruzi	beta tubulin, putative	0.0291	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Echinococcus granulosus	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0203	0.6794	0.6614
Brugia malayi	beta-tubulin, identical	0.0291	1	1
Brugia malayi	larval opioid receptor	0.0203	0.6794	0.6614
Echinococcus multilocularis	neuropeptide receptor	0.0203	0.6794	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0894	0.0894
Giardia lamblia	Beta tubulin	0.0291	1	1
Echinococcus granulosus	orexin receptor type 2	0.0203	0.6794	0.6479
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0203	0.6794	0.6479
Leishmania major	beta tubulin	0.0291	1	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus granulosus	biogenic amine 5HT receptor	0.0203	0.6794	0.6479
Brugia malayi	AKH receptor	0.0203	0.6794	0.6614
Echinococcus granulosus	neuropeptides capa receptor	0.0203	0.6794	0.6479
Echinococcus granulosus	g-protein coupled receptor	0.0203	0.6794	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Leishmania major	beta tubulin	0.0291	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0894	0.0894
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0894	0.0894
Echinococcus granulosus	tubulin beta 1 chain	0.0291	1	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0203	0.6794	0.6479
Loa Loa (eye worm)	G-protein coupled receptor	0.0203	0.6794	0.6614
Brugia malayi	sulfakinin receptor protein	0.0203	0.6794	0.6614
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0203	0.6794	0.6479
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0203	0.6794	0.6479
Trypanosoma brucei	DNA polymerase kappa, putative	0.0031	0.053	0.053
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0203	0.6794	0.6479
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0203	0.6794	0.6479
Brugia malayi	putative neuropeptide receptor	0.0203	0.6794	0.6614
Toxoplasma gondii	beta-tubulin, putative	0.0291	1	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0203	0.6794	0.6479
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0203	0.6794	0.6614
Echinococcus granulosus	somatostatin receptor	0.0203	0.6794	0.6479
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0203	0.6794	0.6479
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0291	1	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0203	0.6794	0.6479
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0203	0.6794	0.6614
Leishmania major	beta tubulin	0.0291	1	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Plasmodium falciparum	tubulin beta chain	0.0291	1	0.5
Echinococcus granulosus	g protein coupled receptor	0.0203	0.6794	0.6479
Echinococcus multilocularis	neuropeptides capa receptor	0.0203	0.6794	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus granulosus	tm gpcr rhodopsin	0.0203	0.6794	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Plasmodium vivax	tubulin beta chain, putative	0.0291	1	0.5
Echinococcus multilocularis	somatostatin receptor	0.0203	0.6794	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus granulosus	neuropeptides capa receptor	0.0203	0.6794	0.6479
Leishmania major	beta tubulin	0.0291	1	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0203	0.6794	0.6479
Brugia malayi	hypothetical protein	0.0203	0.6794	0.6614
Brugia malayi	G protein-coupled receptor F59B2.13	0.0203	0.6794	0.6614
Brugia malayi	GnHR receptor homolog	0.0203	0.6794	0.6614
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus multilocularis	tubulin subunit beta	0.0291	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0203	0.6794	0.6479
Brugia malayi	G protein-coupled receptor	0.0203	0.6794	0.6614
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0894	0.0894
Giardia lamblia	Beta tubulin	0.0291	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0291	1	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Leishmania major	beta tubulin	0.0291	1	1
Leishmania major	beta tubulin	0.0291	1	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0291	1	1
Echinococcus granulosus	neuropeptide receptor	0.0203	0.6794	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0164	0.5
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Brugia malayi	Serotonin receptor	0.0203	0.6794	0.6614
Toxoplasma gondii	beta-1 tubulin, putative	0.0291	1	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0203	0.6794	0.6479
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.0894	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0203	0.6794	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus granulosus	neuropeptide FF receptor 2	0.0203	0.6794	0.6479
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0203	0.6794	0.6614
Trypanosoma brucei	DNA polymerase kappa, putative	0.0031	0.053	0.053
Loa Loa (eye worm)	BEN-1 protein	0.0291	1	1
Leishmania major	beta tubulin	0.0291	1	1
Echinococcus multilocularis	orexin receptor type 2	0.0203	0.6794	0.6479
Onchocerca volvulus		0.0203	0.6794	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0203	0.6794	0.6479
Brugia malayi	Serotonin receptor	0.0203	0.6794	0.6614
Trypanosoma brucei	DNA polymerase IV, putative	0.0035	0.0653	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus granulosus	G protein coupled receptor 139	0.0203	0.6794	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Echinococcus granulosus	serotonin receptor	0.0203	0.6794	0.6479
Schistosoma mansoni	tubulin subunit beta	0.0291	1	1
Leishmania major	beta tubulin	0.0291	1	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614
Brugia malayi	hypothetical protein	0.0203	0.6794	0.6614
Loa Loa (eye worm)	hypothetical protein	0.0203	0.6794	0.6614

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 658 nM	Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay	ChEMBL.	22119461

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1933159

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1600555