TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 416.554 | Formula: C24H36N2O4
H donors: 4 H acceptors: 2 LogP: 4.1 Rotable bonds: 15
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1O)CNCCCCCCCCNCc1ccc(c(c1)O)OC
InChi: 1S/C24H36N2O4/c1-29-23-11-9-19(15-21(23)27)17-25-13-7-5-3-4-6-8-14-26-18-20-10-12-24(30-2)22(28)16-20/h9-12,15-16,25-28H,3-8,13-14,17-18H2,1-2H3
InChiKey: NECSKTHREYMJLH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	larval opioid receptor	0.01393	0.259257	0.311757
Loa Loa (eye worm)	hypothetical protein	0.00743494	0.122979	0.100556
Echinococcus multilocularis	allatostatin A receptor	0.01393	0.259257	0.250312
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.01393	0.259257	0.311757
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Loa Loa (eye worm)	neuropeptide F receptor	0.01393	0.259257	0.240317
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.01393	0.259257	0.240317
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.01393	0.259257	0.311757
Loa Loa (eye worm)	tryptophan hydroxylase 1	0.0214969	0.418024	0.403144
Loa Loa (eye worm)	hypothetical protein	0.0491016	0.99722	0.997149
Echinococcus multilocularis	G protein coupled receptor 139	0.01393	0.259257	0.250312
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Brugia malayi	sulfakinin receptor protein	0.01393	0.259257	0.311757
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.00321807	0.0345018	0.00981579
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.00321807	0.0345018	0.0414885
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Onchocerca volvulus		0.01393	0.259257	1
Echinococcus multilocularis	fmrfamide receptor	0.01393	0.259257	0.250312
Brugia malayi	Dopamine receptor protein 1	0.0412081	0.831599	1
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Trypanosoma cruzi	trypanothione reductase, putative	0.0061823	0.0966966	0.10624
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Schistosoma mansoni	growth hormone secretagogue receptor	0.01393	0.259257	0.250312
Schistosoma mansoni	amine GPCR	0.01393	0.259257	0.250312
Loa Loa (eye worm)	solute carrier family 6 member 4	0.00743494	0.122979	0.100556
Echinococcus granulosus	tachykinin peptides receptor 99D	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Echinococcus multilocularis	neuropeptides capa receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.00743494	0.122979	0.112389
Trichomonas vaginalis	CMGC family protein kinase	0.0210185	0.407986	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.00703535	0.114595	0.0919569
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.01393	0.259257	0.250312
Echinococcus granulosus	neuropeptide Y receptor	0.01393	0.259257	0.250312
Echinococcus granulosus	neuropeptides capa receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0491016	0.99722	0.997186
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.01393	0.259257	0.311757
Echinococcus granulosus	serotonin transporter	0.00743494	0.122979	0.112389
Brugia malayi	neuropeptide F receptor	0.01393	0.259257	0.311757
Echinococcus granulosus	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Loa Loa (eye worm)	G-protein coupled receptor	0.01393	0.259257	0.240317
Brugia malayi	Melatonin receptor type 1A	0.01393	0.259257	0.311757
Echinococcus granulosus	neuropeptide receptor	0.01393	0.259257	0.250312
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.00295208	0.0289208	0.042897
Brugia malayi	hypothetical protein	0.00743494	0.122979	0.147883
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.0492341	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.01393	0.259257	0.250312
Echinococcus granulosus	neuropeptide receptor A26	0.01393	0.259257	0.250312
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0210185	0.407986	0.496391
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.00321807	0.0345018	0.0228431
Loa Loa (eye worm)	neuropeptide F receptor	0.01393	0.259257	0.240317
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Brugia malayi	G-protein coupled receptor	0.01393	0.259257	0.311757
Echinococcus granulosus	serotonin receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	neuropeptide receptor	0.01393	0.259257	0.250312
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0210185	0.407986	0.496391
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.00743494	0.122979	0.112389
Loa Loa (eye worm)	glutathione reductase	0.0061823	0.0966966	0.0736008
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.00743494	0.122979	0.100556
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.01393	0.259257	0.250312
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.01393	0.259257	0.250312
Schistosoma mansoni	amine GPCR	0.01393	0.259257	0.250312
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.01393	0.259257	0.250312
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.00214235	0.0119312	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.01393	0.259257	0.250312
Echinococcus granulosus	sodium and chloride dependent glycine	0.00743494	0.122979	0.112389
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Echinococcus multilocularis	dro:myosuppressin receptor	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Echinococcus multilocularis	neuropeptide s receptor	0.01393	0.259257	0.250312
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.00214235	0.0119312	0.5
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.00743494	0.122979	0.112389
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Echinococcus granulosus	G protein coupled receptor 139	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Schistosoma mansoni	opsin-like receptor	0.01393	0.259257	0.250312
Brugia malayi	G-protein coupled receptor	0.01393	0.259257	0.311757
Schistosoma mansoni	voltage-gated potassium channel	0.00354798	0.0414239	0.0298488
Onchocerca volvulus		0.01393	0.259257	1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0210185	0.407986	0.496391
Echinococcus granulosus	7tm_1 domain containing protein	0.01393	0.259257	0.250312
Echinococcus multilocularis	mitogen activated protein kinase	0.0210185	0.407986	0.400837
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01393	0.259257	0.250312
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.00743494	0.122979	0.112389
Loa Loa (eye worm)	melatonin receptor type 1A	0.01393	0.259257	0.240317
Brugia malayi	hypothetical protein	0.01393	0.259257	0.311757
Schistosoma mansoni	sodium-dependent amino acid transporter	0.00743494	0.122979	0.112389
Loa Loa (eye worm)	hypothetical protein	0.0412081	0.831599	0.827293
Loa Loa (eye worm)	hypothetical protein	0.00743494	0.122979	0.100556
Echinococcus granulosus	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Brugia malayi	hypothetical protein	0.01393	0.259257	0.311757
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Brugia malayi	Serotonin receptor	0.01393	0.259257	0.311757
Echinococcus granulosus	biogenic amine 5HT receptor	0.0492341	1	1
Schistosoma mansoni	neuropeptide receptor	0.01393	0.259257	0.250312
Onchocerca volvulus		0.01393	0.259257	1
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.01393	0.259257	0.250312
Schistosoma mansoni	tyrosine 3-monooxygenase	0.0214969	0.418024	0.410996
Trichomonas vaginalis	CMGC family protein kinase	0.0210185	0.407986	1
Loa Loa (eye worm)	hypothetical protein	0.0491016	0.99722	0.997149
Loa Loa (eye worm)	TYRA-2 protein	0.01393	0.259257	0.240317
Schistosoma mansoni	neuropeptide F-like receptor	0.01393	0.259257	0.250312
Echinococcus granulosus	tm gpcr rhodopsin	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.00743494	0.122979	0.100556
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.01393	0.259257	0.250312
Brugia malayi	hypothetical protein	0.01393	0.259257	0.311757
Echinococcus granulosus	hypothetical protein	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Schistosoma mansoni	opsin-like receptor	0.01393	0.259257	0.250312
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.01393	0.259257	0.250312
Brugia malayi	follicle stimulating hormone receptor	0.01393	0.259257	0.311757
Onchocerca volvulus		0.01393	0.259257	1
Onchocerca volvulus		0.01393	0.259257	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.01393	0.259257	0.250312
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.00743494	0.122979	0.280386
Trichomonas vaginalis	CMGC family protein kinase	0.0210185	0.407986	1
Toxoplasma gondii	hypothetical protein	0.00743494	0.122979	0.280386
Schistosoma mansoni	opsin-like receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	orexin receptor type 2	0.01393	0.259257	0.250312
Schistosoma mansoni	amine GPCR	0.01393	0.259257	0.250312
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0210185	0.407986	0.496391
Onchocerca volvulus		0.01393	0.259257	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0210185	0.407986	1
Schistosoma mansoni	adenoreceptor	0.01393	0.259257	0.250312
Toxoplasma gondii	aromatic amino acid hydrolase AAH1	0.00703535	0.114595	0.259216
Schistosoma mansoni	sodium/chloride dependent transporter	0.00743494	0.122979	0.112389
Echinococcus granulosus	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Echinococcus granulosus	somatostatin receptor	0.01393	0.259257	0.250312
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.00743494	0.122979	0.112389
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0492341	1	1
Onchocerca volvulus		0.01393	0.259257	1
Echinococcus multilocularis	g protein coupled receptor	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Echinococcus multilocularis	neuropeptide Y receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Brugia malayi	glutathione reductase	0.0061823	0.0966966	0.116278
Schistosoma mansoni	neuropeptide receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	somatostatin receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.01393	0.259257	0.250312
Schistosoma mansoni	hypothetical protein	0.01393	0.259257	0.250312
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Schistosoma mansoni	serine/threonine protein kinase	0.0210185	0.407986	0.400837
Echinococcus multilocularis	neuropeptide receptor	0.01393	0.259257	0.250312
Schistosoma mansoni	amine GPCR	0.01393	0.259257	0.250312
Echinococcus granulosus	g protein coupled receptor	0.01393	0.259257	0.250312
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.00743494	0.122979	0.280386
Schistosoma mansoni	biogenic amine receptor	0.01393	0.259257	0.250312
Trichomonas vaginalis	CMGC family protein kinase	0.0210185	0.407986	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.01393	0.259257	0.250312
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.01393	0.259257	1
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Schistosoma mansoni	sodium/chloride dependent transporter	0.00762512	0.126969	0.116427
Schistosoma mansoni	voltage-gated potassium channel	0.00354798	0.0414239	0.0298488
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Echinococcus granulosus	neuropeptides capa receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.01393	0.259257	0.250312
Echinococcus multilocularis	sodium and chloride dependent glycine	0.00743494	0.122979	0.112389
Brugia malayi	Serotonin receptor	0.01393	0.259257	0.311757
Brugia malayi	hypothetical protein	0.01393	0.259257	0.311757
Brugia malayi	RE15519p	0.01393	0.259257	0.311757
Plasmodium falciparum	amino acid transporter, putative	0.00743494	0.122979	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0210185	0.407986	0.400837
Onchocerca volvulus		0.01393	0.259257	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.01393	0.259257	0.250312
Echinococcus multilocularis	neuropeptide Y receptor	0.01393	0.259257	0.250312
Schistosoma mansoni	biogenic amine receptor	0.01393	0.259257	0.250312
Leishmania major	C-8 sterol isomerase-like protein	0.040169	0.809799	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.00743494	0.122979	0.147883
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.00321807	0.0345018	0.0228431
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.00743494	0.122979	1
Echinococcus granulosus	tm gpcr rhodopsin	0.01393	0.259257	0.250312
Schistosoma mansoni	hypothetical protein	0.01393	0.259257	0.250312
Echinococcus granulosus	g-protein coupled receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	serotonin receptor	0.0492341	1	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.01393	0.259257	0.250312
Echinococcus granulosus	7TM GPCR rhodopsin	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.00743494	0.122979	0.100556
Trypanosoma brucei	C-8 sterol isomerase, putative	0.040169	0.809799	1
Onchocerca volvulus		0.01393	0.259257	1
Schistosoma mansoni	histamine h1 receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.00743494	0.122979	0.112389
Schistosoma mansoni	neuropeptide receptor	0.01393	0.259257	0.250312
Schistosoma mansoni	amine GPCR	0.01393	0.259257	0.250312
Echinococcus granulosus	g protein coupled receptor	0.01393	0.259257	0.250312
Onchocerca volvulus		0.01393	0.259257	1
Echinococcus multilocularis	serotonin receptor	0.0492341	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01393	0.259257	0.250312
Echinococcus granulosus	biogenic amine 5HT receptor	0.01393	0.259257	0.250312
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Brugia malayi	Thioredoxin reductase	0.0061823	0.0966966	0.116278
Plasmodium vivax	glutathione reductase, putative	0.0061823	0.0966966	0.763321
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.040169	0.809799	0.973785
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0061823	0.0966966	0.0857889
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.01393	0.259257	0.250312
Leishmania major	phenylalanine-4-hydroxylase,phenylalanine-4-hydroxylase, putative	0.00703535	0.114595	0.128673
Echinococcus granulosus	g protein coupled receptor	0.01393	0.259257	0.250312
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.00743494	0.122979	0.147883
Brugia malayi	Dopamine receptor protein 2	0.01393	0.259257	0.311757
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.01393	0.259257	0.250312
Onchocerca volvulus		0.01393	0.259257	1
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.00295208	0.0289208	0.042897
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01393	0.259257	0.250312
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.01393	0.259257	0.250312
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.01393	0.259257	0.240317
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.00743494	0.122979	0.112389
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01393	0.259257	0.250312
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.00743494	0.122979	0.147883
Brugia malayi	GnHR receptor homolog	0.01393	0.259257	0.311757
Schistosoma mansoni	sodium/chloride dependent transporter	0.00743494	0.122979	0.112389
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.00214235	0.0119312	0.5
Giardia lamblia	Kinase, CMGC MAPK	0.0210185	0.407986	1
Echinococcus granulosus	tryptophan hydroxylase	0.00703535	0.114595	0.103904
Schistosoma mansoni	neuropeptide f receptor 76f	0.01393	0.259257	0.250312
Echinococcus granulosus	allatostatin A receptor	0.01393	0.259257	0.250312
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.00743494	0.122979	0.112389
Brugia malayi	MAP kinase sur-1	0.0210185	0.407986	0.490604
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.00743494	0.122979	0.280386
Echinococcus multilocularis	serotonin transporter	0.00743494	0.122979	0.112389
Echinococcus multilocularis	neuropeptide FF receptor 2	0.01393	0.259257	0.250312
Brugia malayi	Biopterin-dependent aromatic amino acid hydroxylase family protein	0.0214969	0.418024	0.502675
Brugia malayi	putative neuropeptide receptor	0.01393	0.259257	0.311757
Echinococcus multilocularis	g protein coupled receptor	0.01393	0.259257	0.250312
Schistosoma mansoni	neuropeptide receptor	0.01393	0.259257	0.250312
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0491016	0.99722	0.997186
Onchocerca volvulus	Neuropeptide F receptor homolog	0.01393	0.259257	1
Brugia malayi	hypothetical protein	0.01393	0.259257	0.311757
Echinococcus granulosus	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0491016	0.99722	0.997186
Loa Loa (eye worm)	hypothetical protein	0.0206264	0.399759	0.384412
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.01393	0.259257	0.250312
Echinococcus granulosus	mitogen activated protein kinase 3	0.0210185	0.407986	0.400837
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Plasmodium falciparum	glutathione reductase	0.0061823	0.0966966	0.763321
Plasmodium falciparum	thioredoxin reductase	0.0061823	0.0966966	0.763321
Echinococcus granulosus	neuropeptide FF receptor 2	0.01393	0.259257	0.250312
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.01393	0.259257	0.240317
Brugia malayi	G protein-coupled receptor	0.01393	0.259257	0.311757
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.00214235	0.0119312	0.5
Echinococcus granulosus	neuropeptide s receptor	0.01393	0.259257	0.250312
Echinococcus granulosus	sex peptide receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.00743494	0.122979	0.112389
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.01393	0.259257	0.250312
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.01393	0.259257	0.250312
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Loa Loa (eye worm)	norepinephrine transporter	0.00743494	0.122979	0.100556
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Loa Loa (eye worm)	serotonin transporter b	0.00743494	0.122979	0.100556
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0491016	0.99722	0.997186
Loa Loa (eye worm)	hypothetical protein	0.00743494	0.122979	0.100556
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01393	0.259257	0.250312
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.01393	0.259257	0.250312
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Echinococcus granulosus	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Leishmania major	trypanothione reductase	0.0061823	0.0966966	0.10624
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.01393	0.259257	0.250312
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.00214235	0.0119312	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.01393	0.259257	0.250312
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.00743494	0.122979	0.112389
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.01393	0.259257	0.240317
Schistosoma mansoni	neuropeptide F-like receptor	0.01393	0.259257	0.250312
Onchocerca volvulus		0.01393	0.259257	1
Echinococcus granulosus	orexin receptor type 2	0.01393	0.259257	0.250312
Echinococcus multilocularis	neuropeptides capa receptor	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.01393	0.259257	0.250312
Brugia malayi	hypothetical protein	0.01393	0.259257	0.311757
Onchocerca volvulus		0.01393	0.259257	1
Plasmodium falciparum	transporter, putative	0.00743494	0.122979	1
Toxoplasma gondii	phenylalanine-4-hydroxylase	0.00703535	0.114595	0.259216
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.01393	0.259257	0.240317
Brugia malayi	putative neuropeptide receptor NPR1	0.01393	0.259257	0.311757
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Echinococcus granulosus	peptide allatostatin:somatostatin	0.01393	0.259257	0.250312
Echinococcus granulosus	neuropeptide Y receptor	0.01393	0.259257	0.250312
Echinococcus granulosus	thioredoxin glutathione reductase	0.0061823	0.0966966	0.0857889
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.01393	0.259257	0.250312
Echinococcus granulosus	mitogen activated protein kinase	0.0210185	0.407986	0.400837
Toxoplasma gondii	thioredoxin reductase	0.0061823	0.0966966	0.214024
Schistosoma mansoni	hypothetical protein	0.01393	0.259257	0.250312
Onchocerca volvulus		0.01393	0.259257	1
Treponema pallidum	sodium- and chloride- dependent transporter	0.00743494	0.122979	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.01393	0.259257	0.311757
Plasmodium vivax	thioredoxin reductase, putative	0.0061823	0.0966966	0.763321
Schistosoma mansoni	hypothetical protein	0.01393	0.259257	0.250312
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0210185	0.407986	0.392849
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.00743494	0.122979	0.112389
Brugia malayi	ORL1-like opioid receptor	0.01393	0.259257	0.311757
Brugia malayi	hypothetical protein	0.01393	0.259257	0.311757
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.01393	0.259257	0.311757
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Echinococcus granulosus	fmrfamide receptor	0.01393	0.259257	0.250312
Echinococcus granulosus	dro:myosuppressin receptor	0.01393	0.259257	0.250312
Onchocerca volvulus		0.01393	0.259257	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.01393	0.259257	0.250312
Brugia malayi	hypothetical protein	0.01393	0.259257	0.311757
Loa Loa (eye worm)	hypothetical protein	0.0492341	1	1
Loa Loa (eye worm)	hypothetical protein	0.040169	0.809799	0.804936
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Trypanosoma brucei	protein kinase, putative	0.0210185	0.407986	0.496391
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0491016	0.99722	0.997186
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.01393	0.259257	0.250312
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01393	0.259257	0.250312
Echinococcus multilocularis	sodium and chloride dependent glycine	0.00743494	0.122979	0.112389
Echinococcus multilocularis	tryptophan hydroxylase	0.00703535	0.114595	0.103904
Echinococcus granulosus	alpha 1A adrenergic receptor	0.01393	0.259257	0.250312
Trypanosoma brucei	trypanothione reductase	0.0061823	0.0966966	0.10624
Loa Loa (eye worm)	G-protein coupled receptor	0.01393	0.259257	0.240317
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.00743494	0.122979	0.147883
Echinococcus granulosus	neuropeptide receptor	0.01393	0.259257	0.250312
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0210185	0.407986	0.496391
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.040169	0.809799	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	g protein coupled receptor	0.01393	0.259257	0.250312
Brugia malayi	G protein-coupled receptor F59B2.13	0.01393	0.259257	0.311757
Plasmodium vivax	amine transporter, putative	0.00743494	0.122979	1
Toxoplasma gondii	aromatic amino acid hydrolase AAH2	0.00703535	0.114595	0.259216
Toxoplasma gondii	hypothetical protein	0.00743494	0.122979	0.280386
Echinococcus granulosus	sodium and chloride dependent glycine	0.00743494	0.122979	0.112389
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Plasmodium vivax	hypothetical protein, conserved	0.00743494	0.122979	1
Brugia malayi	hypothetical protein	0.01393	0.259257	0.311757
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Schistosoma mansoni	alpha-1 adrenergic receptor	0.01393	0.259257	0.250312
Onchocerca volvulus		0.01393	0.259257	1
Onchocerca volvulus		0.01393	0.259257	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.00214235	0.0119312	0.0143474
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Brugia malayi	neuropeptide F receptor	0.01393	0.259257	0.311757
Loa Loa (eye worm)	thioredoxin reductase	0.0061823	0.0966966	0.0736008
Brugia malayi	AKH receptor	0.01393	0.259257	0.311757
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.00214235	0.0119312	0.5
Loa Loa (eye worm)	hypothetical protein	0.00743494	0.122979	0.100556
Echinococcus multilocularis	g-protein coupled receptor	0.01393	0.259257	0.250312
Echinococcus multilocularis	fmrfamide receptor	0.01393	0.259257	0.250312
Brugia malayi	Dopamine receptor	0.01393	0.259257	0.311757
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.00743494	0.122979	0.100556
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.01393	0.259257	0.311757
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.01393	0.259257	0.250312
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0210185	0.407986	0.496391
Schistosoma mansoni	biogenic amine receptor	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.00743494	0.122979	0.100556
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.00743494	0.122979	0.147883
Echinococcus multilocularis	neuropeptide receptor A26	0.01393	0.259257	0.250312
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0210185	0.407986	0.496391
Schistosoma mansoni	myosin xvIII	0.01393	0.259257	0.250312
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0061823	0.0966966	1
Schistosoma mansoni	tyrosine/tryptophan monooxygenase	0.00703535	0.114595	0.103904
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.01393	0.259257	0.240317
Brugia malayi	hypothetical protein	0.01393	0.259257	0.311757
Echinococcus multilocularis	sex peptide receptor	0.01393	0.259257	0.250312
Loa Loa (eye worm)	hypothetical protein	0.00743494	0.122979	0.100556

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 5.5 uM	Antitrypanosomal activity against Trypanosoma brucei MITat 427 clone 221a trypomastigotes after 3 days by alamar blue assay	ChEMBL.	22248858
IC50 (functional)	> 10 uM	Antitrypanosomal activity against Trypanosoma cruzi clone CL-Brener epimastigotes after 14 days by alamar blue assay	ChEMBL.	22248858
IC50 (functional)	= 44.41 uM	Antileishmanial activity against Leishmania donovani S1 promastigotes after 72 hrs by alamar blue assay	ChEMBL.	22248858

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference
Trypanosoma brucei gambiense		22248858
Trypanosoma brucei	ChEMBL23	22248858
Trypanosoma cruzi	ChEMBL23	22248858

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1950473

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1600757