Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MET proto-oncogene, receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase | 0.0167 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0167 | 1 | 1 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0005 | 0 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0167 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0167 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0167 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0167 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0167 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0167 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0167 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0167 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0167 | 1 | 1 |
Echinococcus granulosus | plexin a4 | 0.0025 | 0.1221 | 0.1006 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0167 | 1 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0005 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0167 | 1 | 1 |
Brugia malayi | Plexin repeat family protein | 0.0021 | 0.0986 | 0.0765 |
Schistosoma mansoni | plexin | 0.0012 | 0.0449 | 0.0216 |
Loa Loa (eye worm) | plexin A | 0.0025 | 0.1221 | 0.1006 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0167 | 1 | 0.5 |
Brugia malayi | plexin A | 0.0025 | 0.1221 | 0.1006 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0449 | 0.0216 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0167 | 1 | 0.5 |
Schistosoma mansoni | plexin | 0.0021 | 0.0986 | 0.0765 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0167 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0167 | 1 | 0.5 |
Onchocerca volvulus | 0.0021 | 0.0986 | 1 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0167 | 1 | 0.5 |
Echinococcus multilocularis | plexin a4 | 0.0025 | 0.1221 | 0.1006 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0986 | 0.0765 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0449 | 0.0216 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0167 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.39 uM | Inhibition of 6-His-tagged human recombinant c-met using 5FAM-KKKSPGEYVNIGFG-NH2 as substrate after overnight incubation by TR-FRET assay | ChEMBL. | 22381355 |
IC50 (binding) | = 140 uM | Inhibition of c-Met phosphorylation in human MKN45 cells after 1 hr by Western blot analysis | ChEMBL. | 22381355 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.