TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 384.344 | Formula: C21H12N4O4
H donors: 1 H acceptors: 4 LogP: 3.51 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1)Nc1nnc(o1)c1nc2ccc3c(c2oc1=O)cccc3
InChi: 1S/C21H12N4O4/c26-18(13-7-2-1-3-8-13)23-21-25-24-19(29-21)16-20(27)28-17-14-9-5-4-6-12(14)10-11-15(17)22-16/h1-11H,(H,23,25,26)
InChiKey: CRMRWPITKDWNEV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0258	0.26	0.2724
Echinococcus multilocularis	NCK adaptor protein	0.0169	0.1228	0.1286
Schistosoma mansoni	SH2A	0.0169	0.1228	0.1228
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0169	0.1228	0.1228
Brugia malayi	Tyrosine-protein kinase abl-1	0.0258	0.26	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0187	0.1504	0.1504
Loa Loa (eye worm)	tyrosinase 1	0.0092	0.004	0.0042
Onchocerca volvulus		0.0258	0.26	1
Brugia malayi	hypothetical protein	0.0169	0.1228	0.1286
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0169	0.1228	0.1286
Schistosoma mansoni	tyrosine kinase	0.0258	0.26	0.26
Schistosoma mansoni	signal transduction protein lnk-related	0.0169	0.1228	0.1228
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.26	0.2724
Echinococcus granulosus	growth factor receptor bound protein 2	0.0169	0.1228	0.1286
Echinococcus granulosus	SHC transforming protein 3	0.0169	0.1228	0.1286
Echinococcus granulosus	signal transduction protein lnk realted	0.0169	0.1228	0.1286
Echinococcus granulosus	tyrosine protein kinase shark	0.0258	0.26	0.2724
Brugia malayi	Protein kinase domain containing protein	0.0258	0.26	0.2724
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0258	0.26	0.2724
Loa Loa (eye worm)	SH2 domain-containing protein	0.0169	0.1228	0.1286
Trypanosoma brucei	ornithine decarboxylase	0.025	0.2476	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Echinococcus multilocularis	c src tyrosine kinase	0.0258	0.26	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Brugia malayi	RhoGAP domain containing protein	0.0169	0.1228	0.1286
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0169	0.1228	0.1286
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0709	0.9545	1
Brugia malayi	Protein kinase domain containing protein	0.0258	0.26	0.2724
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0258	0.26	0.2724
Entamoeba histolytica	protein kinase, putative	0.0093	0.0062	0.024
Echinococcus multilocularis	tensin	0.0169	0.1228	0.1286
Echinococcus multilocularis	SH2 motif	0.0169	0.1228	0.1286
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0169	0.1228	0.1286
Echinococcus multilocularis	tensin	0.0169	0.1228	0.1286
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0169	0.1228	0.1228
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0258	0.26	0.2724
Loa Loa (eye worm)	STAT protein	0.0169	0.1228	0.1286
Plasmodium falciparum	S-adenosylmethionine decarboxylase/ornithine decarboxylase	0.025	0.2476	1
Brugia malayi	Variant SH3 domain containing protein	0.0169	0.1228	0.1286
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0258	0.26	0.2724
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0187	0.1504	0.1576
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0169	0.1228	0.1286
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0169	0.1228	0.1286
Loa Loa (eye worm)	SRC-1	0.0258	0.26	0.2724
Onchocerca volvulus		0.0258	0.26	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0709	0.9545	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0258	0.26	0.2724
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0258	0.26	0.2724
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0258	0.26	0.2724
Mycobacterium leprae	PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP DECARBOXYLASE)	0.0096	0.0112	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0169	0.1228	0.1228
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0089	0	0.5
Brugia malayi	SH2 domain containing protein	0.0169	0.1228	0.1286
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0258	0.26	0.2724
Onchocerca volvulus		0.0169	0.1228	0.4722
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.26	0.2724
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0169	0.1228	0.1286
Schistosoma mansoni	tensin	0.0169	0.1228	0.1228
Onchocerca volvulus		0.0169	0.1228	0.4722
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0709	0.9545	1
Entamoeba histolytica	SH2 domain containing protein	0.0169	0.1228	0.4722
Schistosoma mansoni	hypothetical protein	0.0169	0.1228	0.1228
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.26	0.2724
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0187	0.1504	0.1576
Echinococcus multilocularis	tyrosine protein kinase shark	0.0258	0.26	0.2724
Echinococcus multilocularis	tyrosine kinase	0.0258	0.26	0.2724
Mycobacterium ulcerans	diaminopimelate decarboxylase LysA	0.025	0.2476	0.5
Schistosoma mansoni	GTPase activating protein	0.0169	0.1228	0.1228
Echinococcus multilocularis	SHC transforming protein 3	0.0169	0.1228	0.1286
Schistosoma mansoni	tyrosine kinase	0.0258	0.26	0.26
Schistosoma mansoni	shc transforming protein	0.0169	0.1228	0.1228
Onchocerca volvulus		0.0169	0.1228	0.4722
Schistosoma mansoni	growth factor receptor-bound protein	0.0169	0.1228	0.1228
Echinococcus granulosus	SH2 motif	0.0169	0.1228	0.1286
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.26	0.2724
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0169	0.1228	0.4722
Brugia malayi	SH2 domain containing protein	0.0169	0.1228	0.1286
Schistosoma mansoni	suppressor of cytokine signaling	0.0169	0.1228	0.1228
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0258	0.26	0.2724
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0169	0.1228	0.1228
Onchocerca volvulus		0.0092	0.004	0.0155
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0169	0.1228	0.1286
Trypanosoma cruzi	protein kinase, putative	0.0089	0	0.5
Brugia malayi	SH2 domain containing protein	0.0258	0.26	0.2724
Plasmodium vivax	S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative	0.025	0.2476	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0258	0.26	0.2724
Schistosoma mansoni	tyrosinase precursor	0.0092	0.004	0.004
Brugia malayi	Protein kinase domain containing protein	0.0258	0.26	0.2724
Loa Loa (eye worm)	SH2 domain-containing protein	0.0169	0.1228	0.1286
Brugia malayi	protein-tyrosine kinase	0.0258	0.26	0.2724
Schistosoma mansoni	tyrosinase precursor	0.0092	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0709	0.9545	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.26	0.26
Schistosoma mansoni	tensin	0.0169	0.1228	0.1228
Brugia malayi	Sex muscle abnormal protein 5	0.0169	0.1228	0.1286
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0258	0.26	0.2724
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.26	0.2724
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.26	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0187	0.1504	0.1576
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0169	0.1228	0.1286
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0169	0.1228	0.1286
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0258	0.26	0.2724
Schistosoma mansoni	tyrosine kinase	0.0258	0.26	0.26
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0258	0.26	0.2724
Trichomonas vaginalis	diaminopimelate decarboxylase, putative	0.025	0.2476	1
Echinococcus granulosus	tyrosine kinase	0.0258	0.26	0.2724
Echinococcus granulosus	expressed conserved protein	0.0169	0.1228	0.1286
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0169	0.1228	0.1286
Brugia malayi	SRC-1	0.0258	0.26	0.2724
Trichomonas vaginalis	diaminopimelate decarboxylase, putative	0.025	0.2476	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0258	0.26	0.26
Onchocerca volvulus		0.025	0.2476	0.9522
Brugia malayi	SH2 domain containing protein	0.0169	0.1228	0.1286
Echinococcus multilocularis		0.0169	0.1228	0.1286
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.26	0.2724
Loa Loa (eye worm)	pyridoxal-dependent decarboxylase	0.025	0.2476	0.2594
Entamoeba histolytica	protein kinase, putative	0.0169	0.1228	0.4722
Entamoeba histolytica	hypothetical protein	0.0093	0.0062	0.024
Echinococcus multilocularis	SH2 domain containing protein 7	0.0169	0.1228	0.1286
Echinococcus multilocularis	N chimaerin	0.0169	0.1228	0.1286
Loa Loa (eye worm)	TK/ABL protein kinase	0.0258	0.26	0.2724
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0092	0.004	0.0042
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0169	0.1228	0.1286
Brugia malayi	SH2 domain containing protein	0.0169	0.1228	0.1286
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.26	0.2724
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0258	0.26	0.2724
Loa Loa (eye worm)	TK protein kinase	0.0258	0.26	0.2724
Onchocerca volvulus		0.0092	0.004	0.0155
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0169	0.1228	0.1228
Entamoeba histolytica	hypothetical protein	0.0093	0.0062	0.024
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0169	0.1228	0.1286
Echinococcus granulosus	N chimaerin	0.0169	0.1228	0.1286
Echinococcus granulosus	SH2 motif	0.0169	0.1228	0.1286
Echinococcus granulosus	NCK adaptor protein	0.0169	0.1228	0.1286
Brugia malayi	Common central domain of tyrosinase family protein	0.0092	0.004	0.0042
Trichomonas vaginalis	pyridoxal-dependent decarboxylase, putative	0.025	0.2476	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0258	0.26	0.2724
Onchocerca volvulus		0.0169	0.1228	0.4722
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Brugia malayi	SH2 domain containing protein	0.0258	0.26	0.2724
Brugia malayi	Variant SH3 domain containing protein	0.0169	0.1228	0.1286
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.26	0.2724
Trichomonas vaginalis	ornithine decarboxylase, putative	0.025	0.2476	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0258	0.26	0.2724
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0093	0.0062	0.024
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0089	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0258	0.26	0.2724
Echinococcus granulosus	tensin	0.0169	0.1228	0.1286
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0169	0.1228	0.1286
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0092	0.004	0.0042
Trypanosoma cruzi	protein kinase, putative	0.0089	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Echinococcus granulosus	c src tyrosine kinase	0.0258	0.26	0.2724
Schistosoma mansoni	hypothetical protein	0.0169	0.1228	0.1228
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0258	0.26	0.2724
Echinococcus granulosus	tyrosine kinase	0.0258	0.26	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0258	0.26	0.2724
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0709	0.9545	0.9545
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0169	0.1228	0.1286
Loa Loa (eye worm)	ShTK domain-containing protein	0.0092	0.004	0.0042
Toxoplasma gondii	diaminopimelate decarboxylase	0.025	0.2476	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0169	0.1228	0.1286
Echinococcus multilocularis	SH2 motif	0.0169	0.1228	0.1286
Mycobacterium tuberculosis	Diaminopimelate decarboxylase LysA (DAP decarboxylase)	0.025	0.2476	0.5
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0169	0.1228	0.4722
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0258	0.26	1
Entamoeba histolytica	hypothetical protein	0.0093	0.0062	0.024
Entamoeba histolytica	ornithine decarboxylase, putative	0.025	0.2476	0.9522
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0258	0.26	0.2724
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0092	0.004	0.0042
Loa Loa (eye worm)	ShTK domain-containing protein	0.0092	0.004	0.0042
Echinococcus granulosus	hypothetical protein	0.0169	0.1228	0.1286
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Brugia malayi	Variant SH3 domain containing protein	0.0169	0.1228	0.1286
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0092	0.004	0.0042
Brugia malayi	SH2 domain containing protein	0.0169	0.1228	0.1286
Loa Loa (eye worm)	hypothetical protein	0.0092	0.004	0.0042
Schistosoma mansoni	adapter molecule crk	0.0169	0.1228	0.1228
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0169	0.1228	0.1286
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0258	0.26	0.2724
Giardia lamblia	Ornithine decarboxylase	0.025	0.2476	1
Leishmania major	ornithine decarboxylase, putative	0.025	0.2476	1
Brugia malayi	hypothetical protein	0.0258	0.26	0.2724
Trichomonas vaginalis	conserved hypothetical protein	0.0096	0.0112	0.0454
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0169	0.1228	0.1286
Onchocerca volvulus		0.0258	0.26	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0169	0.1228	0.1286
Onchocerca volvulus		0.0092	0.004	0.0155
Brugia malayi	Protein kinase domain containing protein	0.0258	0.26	0.2724
Brugia malayi	SH2 domain containing protein	0.0169	0.1228	0.1286
Onchocerca volvulus		0.0258	0.26	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0187	0.1504	0.1576
Brugia malayi	Protein kinase domain containing protein	0.0258	0.26	0.2724
Schistosoma mansoni	tensin	0.0169	0.1228	0.1228
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0258	0.26	0.2724
Schistosoma mansoni	tyrosine kinase	0.0258	0.26	0.26
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0258	0.26	0.2724
Onchocerca volvulus		0.0169	0.1228	0.4722
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0169	0.1228	0.1286
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0169	0.1228	0.1286
Echinococcus granulosus	tyrosine protein kinase Srms	0.0258	0.26	0.2724
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0258	0.26	0.2724
Schistosoma mansoni	tensin-related	0.0169	0.1228	0.1228
Schistosoma mansoni	vav2	0.0169	0.1228	0.1228
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0169	0.1228	0.1286
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0258	0.26	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0092	0.004	0.0042
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0169	0.1228	0.1286
Loa Loa (eye worm)	SH2 domain-containing protein	0.0169	0.1228	0.1286
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0258	0.26	0.2724
Brugia malayi	SH2 domain containing protein	0.0169	0.1228	0.1286
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0258	0.26	0.2724
Echinococcus granulosus	SH2 domain containing protein 7	0.0169	0.1228	0.1286
Onchocerca volvulus		0.0169	0.1228	0.4722
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Trichomonas vaginalis	ornithine decarboxylase, putative	0.0089	0.0002	0.0008
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0169	0.1228	0.1286
Brugia malayi	ShTK domain containing protein	0.0092	0.004	0.0042
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0169	0.1228	0.1286
Onchocerca volvulus		0.0092	0.004	0.0155
Schistosoma mansoni	tyrosine kinase	0.0258	0.26	0.26
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0187	0.1504	0.1576
Brugia malayi	Tensin	0.0169	0.1228	0.1286
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.26	0.2724
Echinococcus granulosus	tyrosine protein kinase Blk	0.0258	0.26	0.2724
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0187	0.1504	0.1576
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0169	0.1228	0.4722
Brugia malayi	Variant SH3 domain containing protein	0.0169	0.1228	0.1286
Onchocerca volvulus		0.0258	0.26	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1228	0.1286
Echinococcus multilocularis	SH2 motif	0.0169	0.1228	0.1286
Brugia malayi	Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein	0.025	0.2476	0.2594
Schistosoma mansoni	suppressor of cytokine signaling	0.0169	0.1228	0.1228
Schistosoma mansoni	nck2/grb4	0.0169	0.1228	0.1228
Onchocerca volvulus		0.0258	0.26	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0258	0.26	0.2724
Trichomonas vaginalis	ornithine decarboxylase, putative	0.025	0.2476	1
Schistosoma mansoni	tensin-related	0.0169	0.1228	0.1228

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (ADMET)	= 90.9 ug ml-1	Cytotoxicity against human WI38 cells after 96 hrs by MTT assay	ChEMBL.	22204901
IC50 (functional)	= 96.9 ug ml-1	Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay	ChEMBL.	22204901
IC50 (functional)	= 111.4 ug ml-1	Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay	ChEMBL.	22204901

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1933236

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1601372