Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin E receptor 2 (subtype EP2) | Starlite/ChEMBL | References |
Mus musculus | prostaglandin E receptor 3 (subtype EP3) | Starlite/ChEMBL | References |
Mus musculus | prostaglandin E receptor 4 (subtype EP4) | Starlite/ChEMBL | References |
Mus musculus | prostaglandin E receptor 1 (subtype EP1) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 1 10'4nM | Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting | ChEMBL. | 22119471 |
Ki (binding) | = 0.6 nM | Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by liquid scintillation counting | ChEMBL. | 22119471 |
Ki (binding) | = 0.6 nM | Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting | ChEMBL. | 22386979 |
Ki (binding) | = 127 nM | Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting | ChEMBL. | 22119471 |
Ki (binding) | = 127 nM | Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting | ChEMBL. | 22386979 |
Ki (binding) | = 1600 nM | Displacement of [3H]-PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by liquid scintillation counting | ChEMBL. | 22119471 |
Ki (binding) | = 1600 nM | Displacement of [3H]-PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting | ChEMBL. | 22386979 |
Ki (binding) | > 10000 nM | Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 60 mins by scintillation counting | ChEMBL. | 22386979 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.