Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0533 | 0.3827 | 1 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0101 | 0.0625 | 0.0625 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0533 | 0.3827 | 0.3827 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1364 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0533 | 0.3827 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1364 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1364 | 1 | 1 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0118 | 0.075 | 0.196 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0118 | 0.075 | 0.196 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0118 | 0.075 | 0.075 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0533 | 0.3827 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0533 | 0.3827 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0533 | 0.3827 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1364 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.1364 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0118 | 0.075 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1364 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0533 | 0.3827 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0533 | 0.3827 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0533 | 0.3827 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1364 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1364 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0533 | 0.3827 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1364 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1364 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0533 | 0.3827 | 1 |
Giardia lamblia | Kinase, AGC AKT | 0.0101 | 0.0625 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1364 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1364 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1364 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1364 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0533 | 0.3827 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | Inhibition of human RSK2 | ChEMBL. | 22056746 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.