Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.5768 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.5768 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.5768 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.5768 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.5768 | 1 | 1 |
Brugia malayi | Inositol-1 | 0.002 | 0.0022 | 0.0022 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.5768 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.002 | 0.0022 | 0.0022 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2252 | 0.3898 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.002 | 0.0022 | 0.1044 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.5768 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0129 | 0.0213 | 0.0213 |
Leishmania major | dihydroorotate dehydrogenase | 0.5768 | 1 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0246 | 0.0415 | 0.1065 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.5768 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.5768 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.5768 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.2252 | 0.3898 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.5768 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0213 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2252 | 0.3898 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.002 | 0.0022 | 0.0022 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.002 | 0.0022 | 0.0057 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.2252 | 0.3898 | 0.3898 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.2252 | 0.3898 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.002 | 0.0022 | 0.0022 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.5768 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2252 | 0.3898 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2252 | 0.3898 | 0.3884 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.2252 | 0.3898 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2252 | 0.3898 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.2252 | 0.3898 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.002 | 0.0022 | 0.0057 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2252 | 0.3898 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.0246 | 0.0415 | 0.1065 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.2252 | 0.3898 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.5768 | 1 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.0129 | 0.0213 | 0.0213 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.2252 | 0.3898 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0246 | 0.0415 | 0.1065 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0246 | 0.0415 | 0.1065 |
Onchocerca volvulus | Arrow homolog | 0.0007 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.41 uM | Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay | ChEMBL. | 22119125 |
IC50 (functional) | = 2.22 uM | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei 427 after 48 hrs by MTS assay | ChEMBL. | 22850214 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 22850214 | ||
Trypanosoma brucei | ChEMBL23 | 22850214 | |
Homo sapiens | ChEMBL23 | 22119125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.