Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.016 | 0.3695 | 1 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0057 | 0.0731 | 0.0068 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.5506 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0077 | 0.1296 | 0.1115 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.016 | 0.3695 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.016 | 0.3695 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.016 | 0.3695 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0062 | 0.0876 | 0.08 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0768 | 0.0643 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.7167 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.016 | 0.3695 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0062 | 0.0876 | 0.1223 |
Brugia malayi | WGR domain containing protein | 0.0077 | 0.1296 | 0.061 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0146 | 0.3281 | 0.8584 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0768 | 0.1072 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.7167 | 1 |
Brugia malayi | WGR domain containing protein | 0.014 | 0.3122 | 0.258 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.016 | 0.3695 | 0.6178 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0731 | 0.0068 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0077 | 0.1296 | 0.1809 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0062 | 0.0876 | 0.08 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0062 | 0.0876 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.016 | 0.3695 | 0.3198 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0062 | 0.0876 | 0.1223 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2155 | 0.1594 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.016 | 0.3695 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0145 | 0.3248 | 0.2715 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.016 | 0.3695 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.016 | 0.3695 | 0.3198 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.016 | 0.3695 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.014 | 0.3122 | 0.4969 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0077 | 0.1296 | 0.1415 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0067 | 0.0996 | 0.0481 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0062 | 0.0876 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.3248 | 0.2765 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0077 | 0.1296 | 0.1491 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.016 | 0.3695 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0062 | 0.0876 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 0.3248 | 0.4268 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.016 | 0.3695 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1296 | 0.0674 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.014 | 0.3122 | 0.4085 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 0.3248 | 0.4531 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.016 | 0.3695 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0062 | 0.0876 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 0.3248 | 0.4531 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0062 | 0.0876 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0062 | 0.0876 | 0.0157 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0062 | 0.0876 | 0.5 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0077 | 0.1296 | 0.1491 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.3248 | 0.2765 |
Leishmania major | dihydroorotate dehydrogenase | 0.016 | 0.3695 | 1 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.014 | 0.3122 | 1 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.014 | 0.3122 | 0.4357 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 43 nM | Displacement of Eu-labeled VCAM-1 from human VLA alpha4 beta1 expressed in CHO-K1 cells after 60 mins by time-resolved fluorometric analysis | ChEMBL. | 22261021 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.