Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1169 | 0.3815 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0214 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.2995 | 1 | 0.5 |
Brugia malayi | WGR domain containing protein | 0.014 | 0.0327 | 0.0216 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.1169 | 0.3815 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2995 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.2995 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.2995 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2995 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.2995 | 1 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0077 | 0.0113 | 0.0035 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1169 | 0.3815 | 0.3744 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.1169 | 0.3815 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1169 | 0.3815 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.2995 | 1 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.014 | 0.0327 | 0.0251 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.2995 | 1 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.1169 | 0.3815 | 0.3744 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.2995 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1169 | 0.3815 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2995 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2995 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.1169 | 0.3815 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.2995 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.1169 | 0.3815 | 0.5 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0077 | 0.0113 | 0.0297 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.014 | 0.0327 | 0.0578 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.2995 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1169 | 0.3815 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.2995 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0113 | 0.423 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.014 | 0.0327 | 0.0858 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.1169 | 0.3815 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.1169 | 0.3815 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1169 | 0.3815 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
RBA (binding) | = 4 | Displacement of [3H]-estradiol from human ERRalpha LBD expressed in Escherichia coli at 1 uM to 1 pM relative to estradiol | ChEMBL. | 22178552 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.