Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0197 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0197 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0197 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0197 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0197 | 1 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.0197 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0077 | 0.1638 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0197 | 1 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0077 | 0.1638 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0077 | 0.1638 | 0.1638 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0197 | 1 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0077 | 0.1638 | 0.1638 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0077 | 0.1638 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0077 | 0.1638 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0077 | 0.1638 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0197 | 1 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0053 | 0 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0077 | 0.1638 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0197 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0077 | 0.1638 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0077 | 0.1638 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0197 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0197 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0197 | 1 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0077 | 0.1638 | 0.5 |
Onchocerca volvulus | 0.0053 | 0 | 0.5 | |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0077 | 0.1638 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0197 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0077 | 0.1638 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
F (ADMET) | = 10 % | Oral bioavailability in DBA/2 mouse at 30 mg/kg | ChEMBL. | 22197388 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.