Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Probable isocitrate dehydrogenase | 0.0321 | 0.1154 | 0.1128 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0029 | 0.0025 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0029 | 0.0216 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0029 | 0.0029 |
Brugia malayi | hypothetical protein | 0.0039 | 0.008 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0145 | 0.0141 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0046 | 0.0106 | 0.0026 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.2644 | 1 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0107 | 0.0339 | 0.2754 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.008 | 0.0452 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0321 | 0.1154 | 0.1128 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0883 | 0.3291 | 0.3237 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.2644 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2644 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.2644 | 1 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.2644 | 1 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2644 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0136 | 0.0132 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0099 | 0.002 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0321 | 0.1154 | 0.115 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0321 | 0.1154 | 0.1083 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0029 | 0.0216 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0029 | 0.0216 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2644 | 1 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0368 | 0.1331 | 0.1261 |
Brugia malayi | CHE-14 protein | 0.0046 | 0.0106 | 0.0077 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0046 | 0.0106 | 0.0026 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2644 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0099 | 0.002 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.2644 | 1 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0029 | 0.0216 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.008 | 0.0452 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0321 | 0.1154 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0109 | 0.0345 | 0.0267 |
Echinococcus granulosus | tumor protein p63 | 0.0368 | 0.1331 | 0.1261 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0321 | 0.1154 | 0.1128 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.2644 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0029 | 0.0025 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0099 | 0.002 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.2644 | 1 | 1 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0321 | 0.1154 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0029 | 0.0029 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2644 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.2644 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0029 | 0.0216 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0321 | 0.1154 | 0.1083 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.2644 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0321 | 0.1154 | 0.1083 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0153 | 0.0514 | 0.0438 |
Echinococcus multilocularis | protein patched | 0.0046 | 0.0106 | 0.0026 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0321 | 0.1154 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0029 | 0.0216 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0029 | 0.0216 |
Schistosoma mansoni | patched 1 | 0.0046 | 0.0106 | 0.0026 |
Brugia malayi | Isocitrate dehydrogenase | 0.2644 | 1 | 1 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0321 | 0.1154 | 0.1083 |
Echinococcus granulosus | expressed conserved protein | 0.0101 | 0.0314 | 0.0236 |
Onchocerca volvulus | 0.0054 | 0.0136 | 1 | |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0321 | 0.1154 | 0.1128 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0153 | 0.0514 | 0.0438 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0106 | 0.0102 |
Echinococcus multilocularis | expressed conserved protein | 0.0101 | 0.0314 | 0.0236 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.2644 | 1 | 1 |
Schistosoma mansoni | unc-13 (munc13) | 0.0321 | 0.1154 | 0.1083 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0107 | 0.0339 | 0.0261 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.008 | 0.0452 |
Mycobacterium tuberculosis | Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) | 0.0321 | 0.1154 | 0.1154 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2644 | 1 | 0.5 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0321 | 0.1154 | 0.1083 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.1154 | 0.115 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0339 | 0.0335 |
Leishmania major | isocitrate dehydrogenase, putative | 0.0321 | 0.1154 | 0.1128 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0107 | 0.0339 | 0.0261 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.2644 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0029 | 0.0025 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0054 | 0.0136 | 0.0056 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0321 | 0.1154 | 0.1083 |
Echinococcus multilocularis | protein dispatched 1 | 0.0052 | 0.013 | 0.0051 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0029 | 0.0216 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0321 | 0.1154 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0099 | 0.002 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.008 | 0.0452 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0107 | 0.0339 | 0.0311 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0046 | 0.0106 | 0.0026 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.2644 | 1 | 0.5 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0321 | 0.1154 | 1 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0321 | 0.1154 | 0.1128 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0046 | 0.0106 | 0.0102 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0004 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity to LMP2/beta1i in human PC3 cells at 30 uM after 4 hrs by gel-fluorescence assay in presence of UK101-Lys-Cbz treated 1.5 hrs before compound treatment | ChEMBL. | 21741845 | |
Activity (binding) | Effect on LMP2/beta1i cellular distribution in human PC3 cells after 4 hrs by fluorescence microscopy analysis in presence of UK101 treated 1.5 hrs before compound treatment | ChEMBL. | 21741845 | |
Activity (binding) | Binding affinity to LMP2/beta1i in human PC3 cells after 4 hrs using typhoon imaging by gel fluorescence assay | ChEMBL. | 21741845 | |
Activity (binding) | Binding affinity to LMP2/beta1i in human PC3 cells at 30 uM after 4 hrs by fluorescence microscopy analysis in presence of UK101 treated 1.5 hrs before compound treatment | ChEMBL. | 21741845 | |
Activity (binding) | Binding affinity to LMP2/beta1i in human PC3 cells at 30 uM after 4 hrs by fluorescence microscopy analysis in presence of UK101-Lys-Cbz treated 1.5 hrs before compound treatment | ChEMBL. | 21741845 | |
Activity (binding) | Binding affinity to LMP2/beta1i in human PC3 cells at 30 uM after 4 hrs by gel-fluorescence assay in presence of UK101 treated 1.5 hrs before compound treatment | ChEMBL. | 21741845 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.