Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Immunoglobulin I-set domain containing protein | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Onchocerca volvulus | Tyrosine kinase homolog | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Onchocerca volvulus | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2118 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2118 | 1 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0011 | 0.0017 | 0.0017 |
Schistosoma mansoni | unc-13 (munc13) | 0.0257 | 0.1183 | 0.1183 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0031 | 0.0014 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0048 | 0.0031 |
Brugia malayi | Isocitrate dehydrogenase | 0.2118 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2118 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.2118 | 1 | 0.5 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.1183 | 0.1168 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0048 | 0.0031 |
Schistosoma mansoni | vesicular amine transporter | 0.0011 | 0.0017 | 0.0017 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0257 | 0.1183 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.2118 | 1 | 1 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0257 | 0.1183 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0257 | 0.1183 | 0.1168 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0048 | 0.0031 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.2118 | 1 | 0.5 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0257 | 0.1183 | 0.1168 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.2118 | 1 | 1 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0257 | 0.1183 | 0.1168 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0257 | 0.1183 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.2118 | 1 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0035 | 0.0035 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0031 | 0.0014 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2118 | 1 | 1 |
Echinococcus granulosus | twitchin | 0.0014 | 0.0031 | 0.0014 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0257 | 0.1183 | 0.1183 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0035 | 0.0017 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0183 | 0.0829 | 0.0813 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0257 | 0.1183 | 0.1168 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.2118 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0257 | 0.1183 | 0.1168 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0048 | 0.0031 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2118 | 1 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.2118 | 1 | 1 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0257 | 0.1183 | 0.1168 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0257 | 0.1183 | 0.1168 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0257 | 0.1183 | 0.1168 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0257 | 0.1183 | 0.1168 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.2118 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0257 | 0.1183 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.2118 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2118 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0257 | 0.1183 | 0.1168 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.2118 | 1 | 1 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0011 | 0.0017 | 0.0017 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0171 | 0.0772 | 1 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0257 | 0.1183 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0035 | 0.0017 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 0.0829 | 0.0813 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.2118 | 1 | 0.5 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0257 | 0.1183 | 0.1183 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.2118 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.48 uM | Inhibition of VEGFR2 tyrosine kinase activity in VEGF-stimulated human U251 cells after 60 mins by ELISA | ChEMBL. | 22204741 |
IC50 (functional) | = 46.7 uM | Cytotoxicity against EGFR overexpressing human A431 after 12 hrs by cyquant DNA dye-based fluorescence method | ChEMBL. | 22204741 |
IC50 (binding) | = 193.2 uM | Inhibition of PDGFRbeta tyrosine kinase activity in PDGF-BB-stimulated human SF-539 cells after 60 mins by ELISA | ChEMBL. | 22204741 |
IC50 (binding) | > 200 uM | Inhibition of EGFR tyrosine kinase activity in EGF-stimulated human A431 cells after 60 mins by ELISA | ChEMBL. | 22204741 |
IC50 (binding) | > 200 uM | Inhibition of VEGFR1 tyrosine kinase activity in VEGF-stimulated human A498 cells after 60 mins by ELISA | ChEMBL. | 22204741 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.