Detailed information for compound 1602310

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.431 | Formula: C22H20N6O5
  • H donors: 2 H acceptors: 6 LogP: 3.73 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(OC(c1ccc(cc1)[N+](=O)[O-])(C)C)Nc1nc(OCc2ccccc2)c2c(n1)[nH]cn2
  • InChi: 1S/C22H20N6O5/c1-22(2,15-8-10-16(11-9-15)28(30)31)33-21(29)27-20-25-18-17(23-13-24-18)19(26-20)32-12-14-6-4-3-5-7-14/h3-11,13H,12H2,1-2H3,(H2,23,24,25,26,27,29)
  • InChiKey: BCSGNLHUJCZFFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0049 0.088 1
Echinococcus multilocularis musashi 0.0028 0.033 0.028
Schistosoma mansoni transient receptor potential channel 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Echinococcus multilocularis potassium voltage gated channel protein 0.0234 0.5652 0.5629
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0234 0.5652 0.5629
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.2461 0.2423
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0049 0.088 0.0833
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0234 0.5652 0.5629
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0234 0.5652 0.5652
Plasmodium falciparum glutathione reductase 0.0048 0.0865 0.0818
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0234 0.5652 0.5629
Schistosoma mansoni 60S ribosomal protein L21 0.0234 0.5652 0.5629
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0234 0.5652 0.5652
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Brugia malayi ion channel NompC 0.0234 0.5652 0.5652
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0402 1 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0402 1 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0234 0.5652 0.5652
Echinococcus granulosus voltage gated hydrogen channel 1 0.0234 0.5652 0.5629
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated cation channel 0.0234 0.5652 0.5629
Schistosoma mansoni two-pore calcium channel 0.0234 0.5652 0.5629
Entamoeba histolytica tartrate dehydrogenase, putative 0.0049 0.088 0.5
Toxoplasma gondii isocitrate dehydrogenase 0.0402 1 1
Schistosoma mansoni vesicular amine transporter 0.0234 0.5652 0.5629
Brugia malayi Transient-receptor-potential like protein 0.0234 0.5652 0.5652
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0234 0.5652 0.5629
Echinococcus multilocularis hyperpolarization activated cyclic 0.0234 0.5652 0.5629
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0234 0.5652 0.5652
Echinococcus multilocularis transient receptor potential cation channel 0.0234 0.5652 0.5629
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.2779 1
Toxoplasma gondii transporter, cation channel family protein 0.0234 0.5652 0.5629
Loa Loa (eye worm) glutathione reductase 0.0048 0.0865 0.0865
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0234 0.5652 0.5629
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0234 0.5652 0.5629
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0234 0.5652 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0234 0.5652 0.5629
Echinococcus multilocularis potassium voltage gated channel protein 0.0234 0.5652 0.5629
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Echinococcus granulosus ryanodine receptor 44f 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Brugia malayi hypothetical protein 0.0234 0.5652 0.5652
Plasmodium falciparum thioredoxin reductase 0.0048 0.0865 0.0818
Echinococcus granulosus transient receptor potential cation channel 0.0234 0.5652 0.5629
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0234 0.5652 0.5629
Echinococcus multilocularis transient receptor potential cation channel 0.0234 0.5652 0.5629
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0402 1 1
Echinococcus granulosus shaker cognate 0.0234 0.5652 0.5629
Brugia malayi Isocitrate dehydrogenase 0.0402 1 1
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0234 0.5652 0.5629
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0234 0.5652 0.5629
Toxoplasma gondii hypothetical protein 0.0234 0.5652 0.5629
Echinococcus multilocularis two pore calcium channel protein 1 0.0234 0.5652 0.5629
Echinococcus granulosus potassium voltage gated channel protein 0.0234 0.5652 0.5629
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0051 0.5
Echinococcus multilocularis potassium large conductance calcium activated 0.0234 0.5652 0.5629
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0234 0.5652 0.5629
Echinococcus multilocularis transient receptor potential cation channel 0.0234 0.5652 0.5629
Schistosoma mansoni unc-13 (munc13) 0.0049 0.088 0.0833
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0402 1 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0402 1 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0402 1 1
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0234 0.5652 0.5629
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0234 0.5652 0.5629
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0234 0.5652 0.5629
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0234 0.5652 0.5652
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0234 0.5652 0.5629
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0865 0.0818
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.2461 0.2423
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0049 0.088 0.0833
Echinococcus multilocularis sodium channel protein 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Brugia malayi glutathione reductase 0.0048 0.0865 0.0865
Brugia malayi intermediate filament protein 0.0028 0.033 0.033
Echinococcus granulosus potassium voltage gated channel protein 0.0234 0.5652 0.5629
Loa Loa (eye worm) voltage-gated potassium channel 0.0234 0.5652 0.5652
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0234 0.5652 0.5629
Loa Loa (eye worm) ryanodine receptor 0.0234 0.5652 0.5652
Echinococcus multilocularis short transient receptor potential channel 6 0.0234 0.5652 0.5629
Echinococcus granulosus voltage dependent calcium channel 0.0234 0.5652 0.5629
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0234 0.5652 0.5629
Schistosoma mansoni calcium-activated potassium channel 0.0234 0.5652 0.5629
Echinococcus granulosus hypothetical protein 0.0234 0.5652 0.5629
Toxoplasma gondii thioredoxin reductase 0.0048 0.0865 0.0818
Schistosoma mansoni ryanodine receptor related 0.0234 0.5652 0.5629
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0234 0.5652 0.5629
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0234 0.5652 0.5629
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0234 0.5652 0.5652
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0402 1 1
Toxoplasma gondii hypothetical protein 0.0234 0.5652 0.5629
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0234 0.5652 0.5652
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Echinococcus multilocularis transient receptor potential cation channel 0.0234 0.5652 0.5629
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0234 0.5652 0.5652
Echinococcus granulosus intermediate filament protein 0.0028 0.033 0.028
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0234 0.5652 0.5652
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0234 0.5652 0.5629
Schistosoma mansoni hypothetical protein 0.0234 0.5652 0.5629
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0234 0.5652 0.5652
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Echinococcus granulosus transient receptor potential gamma protein 0.0234 0.5652 0.5629
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0402 1 1
Schistosoma mansoni isocitrate dehydrogenase 0.0049 0.088 0.0833
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Loa Loa (eye worm) hypothetical protein 0.0049 0.088 0.088
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0234 0.5652 0.5652
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0234 0.5652 0.5629
Echinococcus granulosus transient receptor potential cation channel 0.0234 0.5652 0.5629
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0234 0.5652 0.5629
Echinococcus granulosus voltage gated potassium channel 0.0234 0.5652 0.5629
Brugia malayi cation channel family protein 0.0234 0.5652 0.5652
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0234 0.5652 0.5629
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0049 0.088 0.088
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0234 0.5652 0.5629
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0234 0.5652 0.5652
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0234 0.5652 0.5629
Echinococcus multilocularis voltage gated potassium channel 0.0234 0.5652 0.5629
Echinococcus multilocularis transient receptor potential gamma protein 0.0234 0.5652 0.5629
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0402 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0234 0.5652 0.5629
Loa Loa (eye worm) voltage-dependent calcium channel 0.0234 0.5652 0.5652
Mycobacterium tuberculosis Probable reductase 0.011 0.2461 0.2423
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0234 0.5652 0.5629
Brugia malayi voltage-dependent calcium channel 0.0234 0.5652 0.5652
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0234 0.5652 0.5629
Echinococcus multilocularis voltage gated potassium channel 0.0234 0.5652 0.5629
Echinococcus multilocularis shaker cognate 0.0234 0.5652 0.5629
Echinococcus multilocularis transient receptor potential cation channel 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Schistosoma mansoni transient receptor potential channel 0.0234 0.5652 0.5629
Schistosoma mansoni intermediate filament proteins 0.0028 0.033 0.028
Leishmania major hypothetical protein, conserved 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated ion channel 0.0234 0.5652 0.5629
Echinococcus granulosus potassium voltage gated channel protein 0.0234 0.5652 0.5629
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0234 0.5652 0.5629
Echinococcus granulosus calcium activated potassium channel 0.0234 0.5652 0.5629
Schistosoma mansoni lamin 0.0028 0.033 0.028
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Echinococcus granulosus potassium voltage gated channel protein 0.0234 0.5652 0.5629
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0234 0.5652 0.5629
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0234 0.5652 0.5629
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0402 1 1
Leishmania major isocitrate dehydrogenase, putative 0.0049 0.088 0.0833
Echinococcus granulosus hyperpolarization activated cyclic 0.0234 0.5652 0.5629
Treponema pallidum NADH oxidase 0.0017 0.0051 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.2779 0.2741
Schistosoma mansoni lamin 0.0028 0.033 0.028
Brugia malayi Probable isocitrate dehydrogenase 0.0049 0.088 0.088
Trypanosoma brucei trypanothione reductase 0.0048 0.0865 0.0818
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Echinococcus granulosus hyperpolarization activated cyclic 0.0234 0.5652 0.5629
Echinococcus granulosus transient receptor potential cation channel 0.0234 0.5652 0.5629
Echinococcus multilocularis potassium voltage gated channel protein 0.0234 0.5652 0.5629
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Leishmania major trypanothione reductase 0.0048 0.0865 0.0818
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0234 0.5652 0.5629
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0234 0.5652 0.5629
Echinococcus multilocularis lamin dm0 0.0028 0.033 0.028
Echinococcus multilocularis short transient receptor potential channel 6 0.0234 0.5652 0.5629
Leishmania major hypothetical protein, unknown function 0.0234 0.5652 0.5629
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0402 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0234 0.5652 0.5629
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0234 0.5652 0.5629
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.2779 0.2741
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0234 0.5652 0.5629
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Echinococcus multilocularis voltage dependent calcium channel 0.0234 0.5652 0.5629
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0865 0.0818
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Brugia malayi olfactory channel protein osm-9 0.0234 0.5652 0.5652
Echinococcus granulosus two pore calcium channel protein 1 0.0234 0.5652 0.5629
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.2461 0.8329
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0234 0.5652 1
Echinococcus granulosus lamin 0.0028 0.033 0.028
Brugia malayi Cyclic-nucleotide gated cation channel 0.0234 0.5652 0.5652
Echinococcus granulosus transient receptor potential cation channel 0.0234 0.5652 0.5629
Toxoplasma gondii transporter, cation channel family protein 0.0234 0.5652 0.5629
Echinococcus multilocularis potassium voltage gated channel protein 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0234 0.5652 0.5652
Echinococcus granulosus potassium large conductance calcium activated 0.0234 0.5652 0.5629
Toxoplasma gondii transporter, cation channel family protein 0.0234 0.5652 0.5629
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0234 0.5652 0.5629
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0234 0.5652 0.5629
Schistosoma mansoni transient receptor potential channel 4 0.0234 0.5652 0.5629
Loa Loa (eye worm) hypothetical protein 0.0028 0.033 0.033
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0234 0.5652 0.5629
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.2461 0.2423
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0234 0.5652 0.5652
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0234 0.5652 0.5629
Echinococcus multilocularis sodium leak channel non selective protein 0.0234 0.5652 0.5629
Schistosoma mansoni transient receptor potential channel 0.0234 0.5652 0.5629
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0865 0.0818
Loa Loa (eye worm) intermediate filament protein 0.0028 0.033 0.033
Echinococcus granulosus sodium leak channel non selective protein 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Loa Loa (eye worm) hypothetical protein 0.0027 0.0317 0.0317
Echinococcus multilocularis voltage dependent calcium channel 0.0234 0.5652 0.5629
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0402 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0865 0.0818
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0049 0.088 0.0833
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0234 0.5652 0.5629
Loa Loa (eye worm) voltage-gated potassium channel 0.0234 0.5652 0.5652
Loa Loa (eye worm) isocitrate dehydrogenase 0.0402 1 1
Schistosoma mansoni voltage-dependent calcium channel 0.0234 0.5652 0.5629
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0049 0.088 0.088
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Echinococcus granulosus potassium voltage gated channel protein 0.0234 0.5652 0.5629
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0049 0.088 1
Loa Loa (eye worm) ion channel NompC 0.0234 0.5652 0.5652
Echinococcus granulosus two pore calcium channel protein 2 0.0234 0.5652 0.5629
Onchocerca volvulus 0.0234 0.5652 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0234 0.5652 0.5629
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0865 0.0818
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0234 0.5652 0.5652
Echinococcus multilocularis ryanodine receptor 44f 0.0234 0.5652 0.5629
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0049 0.088 0.0833
Echinococcus granulosus TRP transient receptor potential channel 0.0234 0.5652 0.5629
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0234 0.5652 0.5629
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0234 0.5652 1
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0049 0.088 0.148
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0234 0.5652 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.033 0.033
Echinococcus multilocularis transfer RNA-Gly 0.0234 0.5652 0.5629
Echinococcus multilocularis calcium activated potassium channel 0.0234 0.5652 0.5629
Echinococcus granulosus voltage dependent calcium channel 0.0234 0.5652 0.5629
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.2461 0.2423
Plasmodium vivax glutathione reductase, putative 0.0048 0.0865 0.0818
Loa Loa (eye worm) voltage-gated calcium channel 0.0234 0.5652 0.5652
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0234 0.5652 0.5629
Echinococcus granulosus transient receptor potential cation channel 0.0234 0.5652 0.5629
Echinococcus multilocularis lamin 0.0028 0.033 0.028
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Echinococcus multilocularis two pore calcium channel protein 2 0.0234 0.5652 0.5629
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Echinococcus granulosus voltage gated potassium channel 0.0234 0.5652 0.5629
Brugia malayi cation channel family protein 0.0234 0.5652 0.5652
Echinococcus granulosus transient receptor potential cation channel 0.0234 0.5652 0.5629
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0234 0.5652 0.5652
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0234 0.5652 0.5629
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0234 0.5652 0.5629
Toxoplasma gondii isocitrate dehydrogenase 0.0402 1 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0234 0.5652 0.5652
Echinococcus granulosus sodium channel protein 0.0234 0.5652 0.5629
Echinococcus multilocularis conserved hypothetical protein 0.0234 0.5652 0.5629
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0234 0.5652 0.5629
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.2779 0.2741
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0402 1 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0234 0.5652 0.5629
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0234 0.5652 0.5629
Echinococcus granulosus short transient receptor potential channel 6 0.0234 0.5652 0.5629
Loa Loa (eye worm) calcium channel 0.0234 0.5652 0.5652
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0402 1 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0051 0.0051
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0049 0.088 0.088
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0234 0.5652 0.5629
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0234 0.5652 0.5629
Brugia malayi Thioredoxin reductase 0.0048 0.0865 0.0865
Echinococcus multilocularis transient receptor potential cation channel 0.0234 0.5652 0.5629
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0234 0.5652 0.5652
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0865 0.0865
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Echinococcus granulosus lamin dm0 0.0028 0.033 0.028
Loa Loa (eye worm) hypothetical protein 0.0234 0.5652 0.5652
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0234 0.5652 0.5629
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.2461 0.2423
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.033 0.033
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0049 0.088 0.088
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0049 0.088 0.0833
Brugia malayi Probable isocitrate dehydrogenase 0.0049 0.088 0.088
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0049 0.088 0.0833
Echinococcus multilocularis hyperpolarization activated cyclic 0.0234 0.5652 0.5629
Schistosoma mansoni voltage-gated potassium channel 0.0234 0.5652 0.5629
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0402 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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