Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 614 aa | 496 aa | 24.0 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 574 aa | 24.0 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 614 aa | 564 aa | 29.8 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 570 aa | 25.4 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 614 aa | 547 aa | 32.5 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 507 aa | 26.4 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 583 aa | 30.7 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 573 aa | 30.5 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 581 aa | 27.0 % | |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 614 aa | 642 aa | 34.0 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 632 aa | 25.6 % | |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 614 aa | 642 aa | 34.1 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 614 aa | 602 aa | 24.3 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 614 aa | 531 aa | 39.7 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 614 aa | 577 aa | 40.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.748 uM | Inhibition of AChE in rat cortex homogenates using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | ChEMBL. | 22019465 |
Inhibition (binding) | Inhibition of BACE1 at 20 ug/mL by FRET assay | ChEMBL. | 22019465 | |
Inhibition (functional) | = 0.5 % | Antagonist activity at histamine H3 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamine-induced cAMP accumulation at 1 uM after 5 hrs by luciferase reporter gene assay | ChEMBL. | 22019465 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.