Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0015 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin VII | 0.0141 | 0.0361 | 1 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0015 | 0 | 0.5 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.1203 | 0.3393 | 1 |
Mycobacterium leprae | Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) | 0.0015 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0141 | 0.0361 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0141 | 0.0361 | 1 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0141 | 0.0361 | 1 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0141 | 0.0361 | 0.0361 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0141 | 0.0361 | 0.0361 |
Plasmodium falciparum | plasmepsin V | 0.0141 | 0.0361 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0015 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0141 | 0.0361 | 1 |
Onchocerca volvulus | 0.0141 | 0.0361 | 1 | |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0141 | 0.0361 | 1 |
Plasmodium vivax | plasmepsin V, putative | 0.0141 | 0.0361 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0141 | 0.0361 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0141 | 0.0361 | 1 |
Plasmodium vivax | plasmepsin IV, putative | 0.0141 | 0.0361 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0141 | 0.0361 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0361 | 1 |
Plasmodium falciparum | plasmepsin III | 0.0141 | 0.0361 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0015 | 0 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0141 | 0.0361 | 1 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0141 | 0.0361 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0015 | 0 | 0.5 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0141 | 0.0361 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0141 | 0.0361 | 0.0361 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0141 | 0.0361 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0015 | 0 | 0.5 |
Brugia malayi | Pepsin A precursor | 0.0141 | 0.0361 | 1 |
Mycobacterium leprae | POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0141 | 0.0361 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0361 | 1 |
Brugia malayi | hypothetical protein | 0.0141 | 0.0361 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0141 | 0.0361 | 0.0361 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0141 | 0.0361 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0141 | 0.0361 | 0.0361 |
Plasmodium falciparum | plasmepsin I | 0.0141 | 0.0361 | 1 |
Brugia malayi | hypothetical protein | 0.0141 | 0.0361 | 1 |
Mycobacterium leprae | POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0015 | 0 | 0.5 |
Plasmodium vivax | aspartyl protease, putative | 0.0141 | 0.0361 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0141 | 0.0361 | 0.0361 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0141 | 0.0361 | 0.0361 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0141 | 0.0361 | 0.0361 |
Plasmodium vivax | aspartyl protease, putative | 0.0141 | 0.0361 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0141 | 0.0361 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0141 | 0.0361 | 0.0361 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0015 | 0 | 0.5 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0015 | 0 | 0.5 |
Plasmodium vivax | aspartyl protease, putative | 0.0141 | 0.0361 | 1 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0141 | 0.0361 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0141 | 0.0361 | 0.0361 |
Toxoplasma gondii | aspartyl protease | 0.0141 | 0.0361 | 1 |
Plasmodium falciparum | plasmepsin X | 0.0141 | 0.0361 | 1 |
Onchocerca volvulus | 0.0141 | 0.0361 | 1 | |
Plasmodium falciparum | plasmepsin IX | 0.0141 | 0.0361 | 1 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.1203 | 0.3393 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0015 | 0 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0141 | 0.0361 | 1 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0141 | 0.0361 | 0.0361 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0141 | 0.0361 | 1 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0361 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0141 | 0.0361 | 1 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0015 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -7.671 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.632 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.442 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.425 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.262 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.228 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.142 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.087 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.021 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.938 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.745 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.695 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.678 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.563 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.533 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.379 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.331 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.213 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.207 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.13 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.642 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.477 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.